P05556

※ Protein Information

Tag	Content
UniProt Accession	ITB1_HUMAN; P05556;
Entrez ID	3688
GenBank Protein ID	NM_002211.3; NM_033668.2; NM_133376.2;
GenBank Nucleotide ID	NP_002202.2; NP_391988.1; NP_596867.1;
Protein Name	Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
Gene Name	ITGB1; FNRB; MDF2; MSK12
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for(view all) Functional Description Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).;Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.;(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).
Sequence (Fasta)	MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT 60 SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK GTAEKLKPED ITQIQPQQLV 120 LRLRSGEPQT FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 180 RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTNKGE VFNELVGKQR 240 ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 300 CHLENNMYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 360 SANSSNVIQL IIDAYNSLSS EVILENGKLS EGVTISYKSY CKNGVNGTGE NGRKCSNISI 420 GDEVQFEISI TSNKCPKKDS DSFKIRPLGF TEEVEVILQY ICECECQSEG IPESPKCHEG 480 NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK 540 RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTSTCE 600 ASNGQICNGR GICECGVCKC TDPKFQGQTC EMCQTCLGVC AEHKECVQCR AFNKGEKKDT 660 CTQECSYFNI TKVESRDKLP QPVQPDPVSH CKEKDVDDCW FYFTYSVNGN NEVMVHVVEN 720 PECPTGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN 780 PIYKSAVTTV VNPKYEGK 799 Fasta Sequence >P05556\|ITGB1; FNRB; MDF2; MSK12\|Homo sapiens (Human) MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Phosphorylation	Gastric cancer	P		23857544
1	[Reference]: Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin 1 and 3
2	Threonine Phosphorylation	Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma	P	T788	19115199
2	[Reference]: Transforming growth factor (TGF)-beta1 specifically phosphorylates beta1 integrin (threonine 788-789) via Smad-2 and Smad-3, causing a conformational change of the extracellular component with an inside-out mechanism.
3	Threonine Phosphorylation	Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma	P	T789	19115199
3	[Reference]: However, in the former, the intracytoplasmic tail of beta1 integrin is constitutively phosphorylated at threonine 788-789 and the extracellular part is conformationally activated.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 11) (view all)	MESH:D002114 ; Calcinosis MESH:D002294 ; Carcinoma, Squamous Cell MESH:D009202 ; Cardiomyopathies MESH:D002311 ; Cardiomyopathy, Dilated MESH:D004715 ; Endometriosis MESH:D005911 ; Gliosis MESH:D006333 ; Heart Failure MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D009361 ; Neoplasm Invasiveness MESH:D009362 ; Neoplasm Metastasis MESH:D002289 ; Carcinoma, Non-Small-Cell Lung
DisGeNet (Curated) (count: 11) (view all)	C0006663; Calcinosis C0007131; Non-Small Cell Lung Carcinoma C0007137; Squamous cell carcinoma C0007193; Cardiomyopathy, Dilated C0014175; Endometriosis C0017639; Gliosis C0018801; Heart failure C0023893; Liver Cirrhosis, Experimental C0027626; Neoplasm Invasiveness C0027627; Neoplasm Metastasis C0878544; Cardiomyopathies
GWASdb (count: 7) (view all)	rs10508776; Suicide attempts in bipolar disorder; bipolar disorder rs2153875; Cognitive impairment induced by topiramate; cognitive disorder rs4587680; White matter integrity; bipolar disorder\|brain disease rs2488326; Salmonella-induced pyroptosis; Null rs2230396; Salmonella-induced pyroptosis; Null rs9417094; Multiple complex diseases; Null rs2488336; LDL lipoproteins; atherosclerosis

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 20) (view all)	13 IFWIGLISSVCCVFA dbPAF 130 LRSGEPQTFTLKFKR dbPAF 14 FWIGLISSVCCVFAQ dbPAF 141 KFKRAEDYPIDLYYL dbPAF 147 DYPIDLYYLMDLSYS dbPAF 186 DFRIGFGSFVEKTVM dbPAF 197 KTVMPYISTTPAKLR dbPAF 199 VMPYISTTPAKLRNP dbPAF 22 VCCVFAQTDENRCLK dbPAF 224 FSYKNVLSLTNKGEV dbPAF 226 YKNVLSLTNKGEVFN dbPAF 327 AHLVQKLSENNIQTI dbPAF 333 LSENNIQTIFAVTEE dbPAF 549 DNTNEIYSGKFCECD dbPAF 777 KMNAKWDTGENPIYK dbPAF 783 DTGENPIYKSAVTTV dbPAF 785 GENPIYKSAVTTVVN dbPAF 788 PIYKSAVTTVVNPKY dbPAF 789 IYKSAVTTVVNPKYE dbPAF 795 TTVVNPKYEGK**** dbPAF
Acetylation (count: 4)	619 ICECGVCKCTDPKFQ PLMD 678 TKVESRDKLPQPVQP PLMD 774 EKEKMNAKWDTGENP PLMD 794 VTTVVNPKYEGK*** PLMD
Ubiquitination (count: 23) (view all)	107 KGTAEKLKPEDITQI PLMD 134 EPQTFTLKFKRAEDY PLMD 163 KDDLENVKSLGTDLM PLMD 190 GFGSFVEKTVMPYIS PLMD 202 YISTTPAKLRNPCTS PLMD 228 NVLSLTNKGEVFNEL PLMD 238 VFNELVGKQRISGNL PLMD 346 EEFQPVYKELKNLIP PLMD 398 EGVTISYKSYCKNGV PLMD 518 DMDAYCRKENSSEIC PLMD 551 TNEIYSGKFCECDNF PLMD 575 CGGNGVCKCRVCECN PLMD 619 ICECGVCKCTDPKFQ PLMD 672 CSYFNITKVESRDKL PLMD 678 TKVESRDKLPQPVQP PLMD 692 PDPVSHCKEKDVDDC PLMD 765 HDRREFAKFEKEKMN PLMD 768 REFAKFEKEKMNAKW PLMD 774 EKEKMNAKWDTGENP PLMD 784 TGENPIYKSAVTTVV PLMD 794 VTTVVNPKYEGK* PLMD 798 VNPKYEGK***** PLMD 87 IENPRGSKDIKKNKN PLMD
Sumoylation (count: 3)	774 EKEKMNAKWDTGENP PLMD 784 TGENPIYKSAVTTVV PLMD 794 VTTVVNPKYEGK*** PLMD
Malonylation (count: 1)	794 VTTVVNPKYEGK*** PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

O14713	P05556	IntAct
O14924	P05556	MINT
O60231	P05556	MINT
O75578	P05556	IntAct
P05413	P05556	IntAct
P05556	P05556	IntAct
P05556	P06756	IntAct
P05556	P07948	IntAct
P05556	P08069	HPRD
P05556	P08648	IntAct
P05556	P08962	MINT
P05556	P11177	IntAct
P05556	P13612	IntAct
P05556	P17252	HPRD
P05556	P17301	DIP; IntAct
P05556	P18031	MINT
P05556	P20339	IntAct
P05556	P21333	IntAct; MINT
P05556	P23229	IntAct
P05556	P26006	IntAct
P05556	P29353	MINT
P05556	P30101	MINT
P05556	P32927	IntAct
P05556	P35240	HPRD
P05556	P46109	DIP;HPRD
P05556	P50748	BioGRID
P05556	P53708	IntAct
P05556	P56199	DIP; IntAct
P05556	Q02156	HPRD
P05556	Q13683	IntAct
P05556	Q13797	IntAct
P05556	Q14192	MINT
P05556	Q9BY76	IntAct
P05556	Q9H0F6	IntAct
P05556	Q9NZT1	BioGRID
P05556	Q9UBP9	MINT
P05556	Q9UKX5	IntAct
P05556	Q9UL25	IntAct

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction