| Tag | Content |
|---|---|
| UniProt Accession | JUN_HUMAN; P05412; |
| Entrez ID | 3725 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) |
| Gene Name | JUN |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). |
| Sequence (Fasta) | MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL 60 LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 120 LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA 180 LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP 240 PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM 300 LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F 332 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | sarcoma |
| CTD (Curated) (count: 20) (view all) | MESH:D001171
; Arthritis, Juvenile MESH:D001930 ; Brain Injuries MESH:D002545 ; Brain Ischemia MESH:D001943 ; Breast Neoplasms MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002471 ; Cell Transformation, Neoplastic |
| DisGeNet (Curated) (count: 19) (view all) | C0007621; Neoplastic Cell Transformation
C0007786; Brain Ischemia C0009375; Colonic Neoplasms C0018843; Heat Stroke C0018923; Hemangiosarcoma C0020538; Hypertensive disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 19) (view all) | 170 LHSEPPVYANLSNFN dbPAF
2 ******MTAKMETTF dbPAF 231 ALKEEPQTVPEMPGE dbPAF 239 VPEMPGETPPLSPID dbPAF 243 PGETPPLSPIDMESQ dbPAF 249 LSPIDMESQERIKAE dbPAF |
| Acetylation (count: 5) | 226 HPRLQALKEEPQTVP PLMD
268 RNRIAASKCRKRKLE PLMD 271 IAASKCRKRKLERIA PLMD 273 ASKCRKRKLERIARL PLMD 50 ADPVGSLKPHLRAKN PLMD |
| Ubiquitination (count: 2) | 101 PTQFLCPKNVTDEQE PLMD
50 ADPVGSLKPHLRAKN PLMD |
| Sumoylation (count: 3) | 226 HPRLQALKEEPQTVP PLMD
254 MESQERIKAERKRMR PLMD 56 LKPHLRAKNSDLLTS PLMD |