| Tag | Content |
|---|---|
| UniProt Accession | IF2A_HUMAN; P05198; |
| Entrez ID | 1965 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) |
| Gene Name | EIF2S1; EIF2A |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
| Sequence (Fasta) | MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN 60 KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE 120 YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI 180 NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT 240 TLERTEGLSV LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV 300 DGDDDAEEME AKAED 316 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 5) | MESH:D000544
; Alzheimer Disease MESH:D003072 ; Cognition Disorders MESH:D009410 ; Nerve Degeneration MESH:D013226 ; Status Epilepticus MESH:D012516 ; Osteosarcoma |
| DisGeNet (Curated) (count: 6) | C0002395; Alzheimer's Disease
C0009241; Cognition Disorders C0027746; Nerve Degeneration C0029463; Osteosarcoma C0036341; Schizophrenia C0038220; Status Epilepticus |
| GWASdb (count: 2) | rs8008724; Cisplatin and carboplatin cytotoxicity, in blood cell lines; colorectal cancer|head and neck cancer|testicular cancer|lung cancer
rs2296561; Depression (quantitative trait); mental depression |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 19) (view all) | 110 TKSKTVYSILRHVAE dbPAF
147 DKYKRPGYGAYDAFK dbPAF 150 KRPGYGAYDAFKHAV dbPAF 158 DAFKHAVSDPSILDS dbPAF 161 KHAVSDPSILDSLDL dbPAF 185 NNINRRLTPQAVKIR dbPAF |
| Acetylation (count: 9) (view all) | 101 EAIKCEDKFTKSKTV PLMD
12 SCRFYQHKFPEVEDV PLMD 123 AEVLEYTKDEQLESL PLMD 141 TAWVFDDKYKRPGYG PLMD 143 WVFDDKYKRPGYGAY PLMD 276 FNVQMEPKVVTDTDE PLMD |
| Ubiquitination (count: 20) (view all) | 101 EAIKCEDKFTKSKTV PLMD
104 KCEDKFTKSKTVYSI PLMD 106 EDKFTKSKTVYSILR PLMD 12 SCRFYQHKFPEVEDV PLMD 123 AEVLEYTKDEQLESL PLMD 141 TAWVFDDKYKRPGYG PLMD |
| Malonylation (count: 2) | 106 EDKFTKSKTVYSILR PLMD
61 RRIRSINKLIRIGRN PLMD |