Tag | Content |
---|---|
UniProt Accession | KPCG_HUMAN; P05129; |
Entrez ID | 5582 |
GenBank Protein ID | NM_001316329.1; NM_002739.4; |
GenBank Nucleotide ID | NP_001303258.1; NP_002730.1; |
Protein Name | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) |
Gene Name | PRKCG; PKCG |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by (view all) |
Sequence (Fasta) | MAGLGPGVGD SEGGPRPLFC RKGALRQKVV HEVKSHKFTA RFFKQPTFCS HCTDFIWGIG 60 KQGLQCQVCS FVVHRRCHEF VTFECPGAGK GPQTDDPRNK HKFRLHSYSS PTFCDHCGSL 120 LYGLVHQGMK CSCCEMNVHR RCVRSVPSLC GVDHTERRGR LQLEIRAPTA DEIHVTVGEA 180 RNLIPMDPNG LSDPYVKLKL IPDPRNLTKQ KTRTVKATLN PVWNETFVFN LKPGDVERRL 240 SVEVWDWDRT SRNDFMGAMS FGVSELLKAP VDGWYKLLNQ EEGEYYNVPV ADADNCSLLQ 300 KFEACNYPLE LYERVRMGPS SSPIPSPSPS PTDPKRCFFG ASPGRLHISD FSFLMVLGKG 360 SFGKVMLAER RGSDELYAIK ILKKDVIVQD DDVDCTLVEK RVLALGGRGP GGRPHFLTQL 420 HSTFQTPDRL YFVMEYVTGG DLMYHIQQLG KFKEPHAAFY AAEIAIGLFF LHNQGIIYRD 480 LKLDNVMLDA EGHIKITDFG MCKENVFPGT TTRTFCGTPD YIAPEIIAYQ PYGKSVDWWS 540 FGVLLYEMLA GQPPFDGEDE EELFQAIMEQ TVTYPKSLSR EAVAICKGFL TKHPGKRLGS 600 GPDGEPTIRA HGFFRWIDWE RLERLEIPPP FRPRPCGRSG ENFDKFFTRA APALTPPDRL 660 VLASIDQADF QGFTYVNPDF VHPDARSPTS PVPVPVM 698 |
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Database | Annotation |
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CTD (Curated) (count: 6) | MESH:D004195
; Disease Models, Animal MESH:D006930 ; Hyperalgesia MESH:D008607 ; Intellectual Disability MESH:C537196 ; Spinocerebellar ataxia 14 MESH:D020754 ; Spinocerebellar Ataxias MESH:D014277 ; Trigeminal Neuralgia |
GWASdb (count: 2) | rs307941; Height; Null
rs3745405; Blood pressure; hypertension |
PTM | Modification Sites |
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Phosphorylation (count: 19) (view all) | 145 VHRRCVRSVPSLCGV dbPAF
148 RCVRSVPSLCGVDHT dbPAF 155 SLCGVDHTERRGRLQ dbPAF 195 PNGLSDPYVKLKLIP dbPAF 312 CNYPLELYERVRMGP dbPAF 320 ERVRMGPSSSPIPSP dbPAF |
Acetylation (count: 1) | 197 GLSDPYVKLKLIPDP PLMD |
Ubiquitination (count: 3) | 197 GLSDPYVKLKLIPDP PLMD
199 SDPYVKLKLIPDPRN PLMD 482 GIIYRDLKLDNVMLD PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |