P05129

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession KPCG_HUMAN; P05129;
Entrez ID 5582
GenBank Protein ID NM_001316329.1; NM_002739.4;
GenBank Nucleotide ID NP_001303258.1; NP_002730.1;
Protein Name Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13)
Gene Name PRKCG; PKCG
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCalcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by (view all)
Sequence
(Fasta)
MAGLGPGVGD SEGGPRPLFC RKGALRQKVV HEVKSHKFTA RFFKQPTFCS HCTDFIWGIG 60
KQGLQCQVCS FVVHRRCHEF VTFECPGAGK GPQTDDPRNK HKFRLHSYSS PTFCDHCGSL 120
LYGLVHQGMK CSCCEMNVHR RCVRSVPSLC GVDHTERRGR LQLEIRAPTA DEIHVTVGEA 180
RNLIPMDPNG LSDPYVKLKL IPDPRNLTKQ KTRTVKATLN PVWNETFVFN LKPGDVERRL 240
SVEVWDWDRT SRNDFMGAMS FGVSELLKAP VDGWYKLLNQ EEGEYYNVPV ADADNCSLLQ 300
KFEACNYPLE LYERVRMGPS SSPIPSPSPS PTDPKRCFFG ASPGRLHISD FSFLMVLGKG 360
SFGKVMLAER RGSDELYAIK ILKKDVIVQD DDVDCTLVEK RVLALGGRGP GGRPHFLTQL 420
HSTFQTPDRL YFVMEYVTGG DLMYHIQQLG KFKEPHAAFY AAEIAIGLFF LHNQGIIYRD 480
LKLDNVMLDA EGHIKITDFG MCKENVFPGT TTRTFCGTPD YIAPEIIAYQ PYGKSVDWWS 540
FGVLLYEMLA GQPPFDGEDE EELFQAIMEQ TVTYPKSLSR EAVAICKGFL TKHPGKRLGS 600
GPDGEPTIRA HGFFRWIDWE RLERLEIPPP FRPRPCGRSG ENFDKFFTRA APALTPPDRL 660
VLASIDQADF QGFTYVNPDF VHPDARSPTS PVPVPVM 698

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationSpinocerebellar ataxiaDT51415964845
[Reference]: Missense mutations of PKCG associated with familial SCA14 decrease phosphorylation of T514, T655, T674.
2Threonine PhosphorylationSpinocerebellar ataxiaDT65515964845
[Reference]: Missense mutations of PKCG associated with familial SCA14 decrease phosphorylation of T514, T655, T674.
3Threonine PhosphorylationSpinocerebellar ataxiaDT67415964845
[Reference]: Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 6)
MESH:D004195 ; Disease Models, Animal
MESH:D006930 ; Hyperalgesia
MESH:D008607 ; Intellectual Disability
MESH:C537196 ; Spinocerebellar ataxia 14
MESH:D020754 ; Spinocerebellar Ataxias
MESH:D014277 ; Trigeminal Neuralgia
GWASdb
(count: 2)
rs307941; Height; Null
rs3745405; Blood pressure; hypertension

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 19)
(view all)
145       VHRRCVRSVPSLCGV     dbPAF
148       RCVRSVPSLCGVDHT     dbPAF
155       SLCGVDHTERRGRLQ     dbPAF
195       PNGLSDPYVKLKLIP     dbPAF
312       CNYPLELYERVRMGP     dbPAF
320       ERVRMGPSSSPIPSP     dbPAF
Acetylation
(count: 1)
197       GLSDPYVKLKLIPDP     PLMD
Ubiquitination
(count: 3)
197       GLSDPYVKLKLIPDP     PLMD
199       SDPYVKLKLIPDPRN     PLMD
482       GIIYRDLKLDNVMLD     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource