Tag | Content |
---|---|
UniProt Accession | S10A8_HUMAN; P05109; |
Entrez ID | 6279 |
GenBank Protein ID | NM_001319197.1; NM_001319198.1; NM_001319201.1; NM_002964.4; |
GenBank Nucleotide ID | NP_001306126.1; NP_001306127.1; NP_001306130.1; NP_002955.2; |
Protein Name | Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A) |
Gene Name | S100A8; CAGA; CFAG; MRP8 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NA(view all) |
Sequence (Fasta) | MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI 60 NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE 94 |
|
Database | Annotation |
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CTD (Curated) (count: 5) | MESH:D003876
; Dermatitis, Atopic MESH:D003877 ; Dermatitis, Contact MESH:D007627 ; Keloid MESH:D015470 ; Leukemia, Myeloid, Acute MESH:D015674 ; Mammary Neoplasms, Animal |
PTM | Modification Sites |
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Phosphorylation (count: 8) (view all) | 11 ELEKALNSIIDVYHK dbPAF
16 LNSIIDVYHKYSLIK dbPAF 3 *****MLTELEKALN dbPAF 30 KGNFHAVYRDDLKKL dbPAF 40 DLKKLLETECPQYIR dbPAF 45 LETECPQYIRKKGAD dbPAF |
Acetylation (count: 1) | 18 SIIDVYHKYSLIKGN PLMD |
Glycation (count: 2) | 35 AVYRDDLKKLLETEC PLMD
7 *MLTELEKALNSIID PLMD |