Tag | Content |
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UniProt Accession | ITB2_HUMAN; P05107; |
Entrez ID | 3689 |
GenBank Protein ID | NM_000211.4; NM_001127491.2; NM_001303238.1; |
GenBank Nucleotide ID | NP_000202.3; NP_001120963.2; NP_001290167.1; |
Protein Name | Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) |
Gene Name | ITGB2; CD18; MFI7 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). |
Sequence (Fasta) | MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI 60 RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG QAAAFNVTFR 120 RAKGYPIDLY YLMDLSYSML DDLRNVKKLG GDLLRALNEI TESGRIGFGS FVDKTVLPFV 180 NTHPDKLRNP CPNKEKECQP PFAFRHVLKL TNNSNQFQTE VGKQLISGNL DAPEGGLDAM 240 MQVAACPEEI GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKRSNEFD 300 YPSVGQLAHK LAENNIQPIF AVTSRMVKTY EKLTEIIPKS AVGELSEDSS NVVQLIKNAY 360 NKLSSRVFLD HNALPDTLKV TYDSFCSNGV THRNQPRGDC DGVQINVPIT FQVKVTATEC 420 IQEQSFVIRA LGFTDIVTVQ VLPQCECRCR DQSRDRSLCH GKGFLECGIC RCDTGYIGKN 480 CECQTQGRSS QELEGSCRKD NNSIICSGLG DCVCGQCLCH TSDVPGKLIY GQYCECDTIN 540 CERYNGQVCG GPGRGLCFCG KCRCHPGFEG SACQCERTTE GCLNPRRVEC SGRGRCRCNV 600 CECHSGYQLP LCQECPGCPS PCGKYISCAE CLKFEKGPFG KNCSAACPGL QLSNNPVKGR 660 TCKERDSEGC WVAYTLEQQD GMDRYLIYVD ESRECVAGPN IAAIVGGTVA GIVLIGILLL 720 VIWKALIHLS DLREYRRFEK EKLKSQWNND NPLFKSATTT VMNPKFAES |
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Database | Annotation |
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CTD (Curated) (count: 14) (view all) | MESH:D001528
; Behcet Syndrome MESH:D002114 ; Calcinosis MESH:D054506 ; Chloracne MESH:D003872 ; Dermatitis MESH:D006349 ; Heart Valve Diseases MESH:D006967 ; Hypersensitivity |
DisGeNet (Curated) (count: 24) (view all) | C0004943; Behcet Syndrome
C0006663; Calcinosis C0011603; Dermatitis C0017563; Gingival Diseases C0017574; Gingivitis C0018824; Heart valve disease |
HGMD (count: 39) (view all) | CD931014; Leukocyte adhesion deficiency; Small deletions
CD951754; Leukocyte adhesion deficiency; Small deletions CD022556; Leukocyte adhesion deficiency; Small deletions CD015390; Leukocyte adhesion deficiency; Small deletions CD015391; Leukocyte adhesion deficiency; Small deletions CD921027; Leukocyte adhesion deficiency; Small deletions |
GWASdb (count: 10) (view all) | rs2838729; Response to taxane treatment (placlitaxel); lung cancer
rs2838732; Alanine aminotransferase (ALT) elevation due to Lapatinib treatment of metastatic breast cancer; breast cancer rs3746972; Bipolar disorder; bipolar disorder rs760456; Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months); rheumatoid arthritis rs760456; Methotrexate clearance (acute lymphoblastic leukemia); acute lymphocytic leukemia|acute leukemia rs3788147; Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months); rheumatoid arthritis |
PTM | Modification Sites |
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Phosphorylation (count: 7) (view all) | 591 NPRRVECSGRGRCRC dbPAF
735 HLSDLREYRRFEKEK dbPAF 745 FEKEKLKSQWNNDNP dbPAF 756 NDNPLFKSATTTVMN dbPAF 758 NPLFKSATTTVMNPK dbPAF 759 PLFKSATTTVMNPKF dbPAF |
Ubiquitination (count: 20) (view all) | 147 LDDLRNVKKLGGDLL PLMD
148 DDLRNVKKLGGDLLR PLMD 174 GFGSFVDKTVLPFVN PLMD 194 LRNPCPNKEKECQPP PLMD 196 NPCPNKEKECQPPFA PLMD 29 SQECTKFKVSSCREC PLMD |