P05107

※ Protein Information

Tag	Content
UniProt Accession	ITB2_HUMAN; P05107;
Entrez ID	3689
GenBank Protein ID	NM_000211.4; NM_001127491.2; NM_001303238.1;
GenBank Nucleotide ID	NP_000202.3; NP_001120963.2; NP_001290167.1;
Protein Name	Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
Gene Name	ITGB2; CD18; MFI7
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). Functional Description Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).
Sequence (Fasta)	MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI 60 RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG QAAAFNVTFR 120 RAKGYPIDLY YLMDLSYSML DDLRNVKKLG GDLLRALNEI TESGRIGFGS FVDKTVLPFV 180 NTHPDKLRNP CPNKEKECQP PFAFRHVLKL TNNSNQFQTE VGKQLISGNL DAPEGGLDAM 240 MQVAACPEEI GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKRSNEFD 300 YPSVGQLAHK LAENNIQPIF AVTSRMVKTY EKLTEIIPKS AVGELSEDSS NVVQLIKNAY 360 NKLSSRVFLD HNALPDTLKV TYDSFCSNGV THRNQPRGDC DGVQINVPIT FQVKVTATEC 420 IQEQSFVIRA LGFTDIVTVQ VLPQCECRCR DQSRDRSLCH GKGFLECGIC RCDTGYIGKN 480 CECQTQGRSS QELEGSCRKD NNSIICSGLG DCVCGQCLCH TSDVPGKLIY GQYCECDTIN 540 CERYNGQVCG GPGRGLCFCG KCRCHPGFEG SACQCERTTE GCLNPRRVEC SGRGRCRCNV 600 CECHSGYQLP LCQECPGCPS PCGKYISCAE CLKFEKGPFG KNCSAACPGL QLSNNPVKGR 660 TCKERDSEGC WVAYTLEQQD GMDRYLIYVD ESRECVAGPN IAAIVGGTVA GIVLIGILLL 720 VIWKALIHLS DLREYRRFEK EKLKSQWNND NPLFKSATTT VMNPKFAES Fasta Sequence >P05107\|ITGB2; CD18; MFI7\|Homo sapiens (Human) MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Glycosylation	Leukocyte adhesion deficiency		C	S284	15924140
1	[Reference]: We identified three children with mendelian susceptibility to mycobacterial disease who were homozygous with respect to a missense mutation in IFNGR2 creating a new N-glycosylation site in the IFNR2 chain.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 14) (view all)	MESH:D001528 ; Behcet Syndrome MESH:D002114 ; Calcinosis MESH:D054506 ; Chloracne MESH:D003872 ; Dermatitis MESH:D006349 ; Heart Valve Diseases MESH:D006967 ; Hypersensitivity MESH:D018370 ; Leukocyte-Adhesion Deficiency Syndrome MESH:C535887 ; Leukocyte adhesion deficiency type 1 MESH:D007960 ; Leukocyte Disorders MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D015473 ; Leukemia, Promyelocytic, Acute MESH:D009401 ; Nephrosis MESH:D011014 ; Pneumonia MESH:D012883 ; Skin Ulcer
DisGeNet (Curated) (count: 24) (view all)	C0004943; Behcet Syndrome C0006663; Calcinosis C0011603; Dermatitis C0017563; Gingival Diseases C0017574; Gingivitis C0018824; Heart valve disease C0020517; Hypersensitivity C0023487; Acute Promyelocytic Leukemia C0023510; Leukocyte Disorders C0023518; Leukocytosis C0023893; Liver Cirrhosis, Experimental C0027720; Nephrosis C0031090; Periodontal Diseases C0031099; Periodontitis C0032285; Pneumonia C0037299; Skin Ulcer C0149770; Rectal abscess C0242597; Leukocyte-Adhesion Deficiency Syndrome C0263454; Chloracne C0267566; Perirectal abscess C0398738; Leukocyte adhesion deficiency type 1 C4020899; Autosomal recessive predisposition C4024862; Recurrent staphylococcal infections C4025198; Recurrent gram-negative bacterial infections
HGMD (count: 39) (view all)	CD931014; Leukocyte adhesion deficiency; Small deletions CD951754; Leukocyte adhesion deficiency; Small deletions CD022556; Leukocyte adhesion deficiency; Small deletions CD015390; Leukocyte adhesion deficiency; Small deletions CD015391; Leukocyte adhesion deficiency; Small deletions CD921027; Leukocyte adhesion deficiency; Small deletions CG024922; Leukocyte adhesion deficiency; Gross deletions CG005045; Leukocyte adhesion deficiency; Gross deletions CG005046; Leukocyte adhesion deficiency; Gross deletions CG044359; Leukocyte adhesion deficiency; Gross deletions CG081063; Leukocyte adhesion deficiency; Gross deletions CM920382; Leukocyte adhesion deficiency; Missense/nonsense CM022411; Leukocyte adhesion deficiency; Missense/nonsense CM087183; Hirschsprung disease-associated enterocolitis ?; Missense/nonsense CM920383; Leukocyte adhesion deficiency; Missense/nonsense CM080419; Leukocyte adhesion deficiency; Missense/nonsense CM066105; Leukocyte adhesion deficiency; Missense/nonsense CM990753; Leukocyte adhesion deficiency; Missense/nonsense CM900145; Leukocyte adhesion deficiency; Missense/nonsense CM900146; Leukocyte adhesion deficiency; Missense/nonsense CM930445; Leukocyte adhesion deficiency; Missense/nonsense CM065288; Leukocyte adhesion deficiency; Missense/nonsense CM900147; Leukocyte adhesion deficiency; Missense/nonsense CM081313; Leukocyte adhesion deficiency; Missense/nonsense CM022412; Leukocyte adhesion deficiency; Missense/nonsense CM014361; Leukocyte adhesion deficiency; Missense/nonsense CM990754; Leukocyte adhesion deficiency; Missense/nonsense CM930446; Leukocyte adhesion deficiency; Missense/nonsense CM014362; Leukocyte adhesion deficiency; Missense/nonsense CM920384; Leukocyte adhesion deficiency; Missense/nonsense CM930447; Leukocyte adhesion deficiency; Missense/nonsense CM920385; Leukocyte adhesion deficiency; Missense/nonsense CM014363; Leukocyte adhesion deficiency; Missense/nonsense CM900148; Leukocyte adhesion deficiency; Missense/nonsense CM040229; Leukocyte adhesion deficiency; Missense/nonsense CS022497; Leukocyte adhesion deficiency; Splicing CS920764; Leukocyte adhesion deficiency; Splicing CS920765; Leukocyte adhesion deficiency; Splicing CS890130; Leukocyte adhesion deficiency; Splicing
GWASdb (count: 10) (view all)	rs2838729; Response to taxane treatment (placlitaxel); lung cancer rs2838732; Alanine aminotransferase (ALT) elevation due to Lapatinib treatment of metastatic breast cancer; breast cancer rs3746972; Bipolar disorder; bipolar disorder rs760456; Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months); rheumatoid arthritis rs760456; Methotrexate clearance (acute lymphoblastic leukemia); acute lymphocytic leukemia\|acute leukemia rs3788147; Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months); rheumatoid arthritis rs3788147; Methotrexate clearance (acute lymphoblastic leukemia); acute lymphocytic leukemia\|acute leukemia rs2838735; Immunoglobulin A; selective IgA deficiency disease rs3788151; Prostate cancer; prostate cancer rs2838738; Urinary metabolites; kidney disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 7) (view all)	591 NPRRVECSGRGRCRC dbPAF 735 HLSDLREYRRFEKEK dbPAF 745 FEKEKLKSQWNNDNP dbPAF 756 NDNPLFKSATTTVMN dbPAF 758 NPLFKSATTTVMNPK dbPAF 759 PLFKSATTTVMNPKF dbPAF 760 LFKSATTTVMNPKFA dbPAF
Ubiquitination (count: 20) (view all)	147 LDDLRNVKKLGGDLL PLMD 148 DDLRNVKKLGGDLLR PLMD 174 GFGSFVDKTVLPFVN PLMD 194 LRNPCPNKEKECQPP PLMD 196 NPCPNKEKECQPPFA PLMD 29 SQECTKFKVSSCREC PLMD 294 HLEDNLYKRSNEFDY PLMD 332 RMVKTYEKLTEIIPK PLMD 362 LIKNAYNKLSSRVFL PLMD 379 NALPDTLKVTYDSFC PLMD 462 DRSLCHGKGFLECGI PLMD 479 CDTGYIGKNCECQTQ PLMD 561 RGLCFCGKCRCHPGF PLMD 633 ISCAECLKFEKGPFG PLMD 636 AECLKFEKGPFGKNC PLMD 658 QLSNNPVKGRTCKER PLMD 744 RFEKEKLKSQWNNDN PLMD 755 NNDNPLFKSATTTVM PLMD 765 TTTVMNPKFAES*** PLMD 96 EDHNGGQKQLSPQKV PLMD

PTM

Modification Sites

Phosphorylation
(count: 7)
(view all)

591       NPRRVECSGRGRCRC     dbPAF
735       HLSDLREYRRFEKEK     dbPAF
745       FEKEKLKSQWNNDNP     dbPAF
756       NDNPLFKSATTTVMN     dbPAF
758       NPLFKSATTTVMNPK     dbPAF
759       PLFKSATTTVMNPKF     dbPAF

Ubiquitination
(count: 20)
(view all)

147       LDDLRNVKKLGGDLL     PLMD
148       DDLRNVKKLGGDLLR     PLMD
174       GFGSFVDKTVLPFVN     PLMD
194       LRNPCPNKEKECQPP     PLMD
196       NPCPNKEKECQPPFA     PLMD
29        SQECTKFKVSSCREC     PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

A6H8M8	P05107	BioGRID
A7YIJ8	P05107	HPRD; MINT
B3KTI1	P05107	BioGRID
B5MED8	P05107	BioGRID
B7Z841	P05107	BioGRID
B9EG97	P05107	BioGRID
C9J6D7	P05107	BioGRID
E5RHP1	P05107	BioGRID
E7ESA6	P05107	HPRD
E7EWZ3	P05107	BioGRID
F5GWG2	P05107	BioGRID
F8VW92	P05107	BioGRID
H0YM25	P05107	BioGRID
O75306	P05107	BioGRID
O75553	P05107	MINT;HPRD
O95498	P05107	HPRD
P00519	P05107	MINT
P00738	P05107	HPRD
P01042	P05107	HPRD
P01241	P05107	BioGRID
P02100	P05107	BioGRID
P05107	P05107	HPRD; BioGRID
P05107	P05362	HPRD
P05107	P05387	BioGRID
P05107	P05496	BioGRID
P05107	P05771	HPRD
P05107	P06730	BioGRID
P05107	P06734	HPRD
P05107	P08185	BioGRID
P05107	P08571	HPRD
P05107	P10242	BioGRID
P05107	P11215	HPRD; IntAct
P05107	P11217	BioGRID
P05107	P13598	HPRD; DIP
P05107	P15428	BioGRID
P05107	P15498	MINT
P05107	P17252	HPRD
P05107	P20701	IntAct
P05107	P20702	HPRD; DIP; IntAct
P05107	P20963	BioGRID
P05107	P22083	HPRD
P05107	P24158	HPRD
P05107	P24723	HPRD
P05107	P25874	BioGRID
P05107	P27701	HPRD
P05107	P29353	MINT
P05107	P31930	BioGRID
P05107	P32942	HPRD
P05107	P35568	MINT
P05107	P43405	HPRD; IntAct
P05107	P48751	BioGRID
P05107	P49757	HPRD; MINT
P05107	P50748	BioGRID
P05107	P52732	BioGRID
P05107	P54259	BioGRID
P05107	P54274	BioGRID
P05107	P63244	HPRD
P05107	P82664	BioGRID
P05107	Q02817	BioGRID
P05107	Q05655	HPRD
P05107	Q09470	BioGRID
P05107	Q12929	MINT
P05107	Q13349	HPRD; IntAct
P05107	Q13418	HPRD
P05107	Q14192	HPRD
P05107	Q14289	HPRD
P05107	Q14773	HPRD
P05107	Q15438	HPRD
P05107	Q15762	HPRD
P05107	Q17RH7	BioGRID
P05107	Q4L235	BioGRID
P05107	Q5D862	BioGRID
P05107	Q6PJP8	BioGRID
P05107	Q6ZS30	BioGRID
P05107	Q71DI3	BioGRID
P05107	Q7L4I2	BioGRID
P05107	Q7Z6G8	MINT
P05107	Q96C32	BioGRID
P05107	Q96S59	HPRD; MINT
P05107	Q99418	HPRD
P05107	Q99704	HPRD; MINT
P05107	Q9BRZ2	BioGRID
P05107	Q9NQ30	HPRD
P05107	Q9NZW4	BioGRID
P05107	Q9UBP9	MINT
P05107	Q9ULL5	BioGRID
P05107	Q9UMF0	HPRD
P05107	Q9UNS2	HPRD; MINT
P05107	Q9UQF2	MINT
P05107	Q9Y3P9	MINT
P05107	Q9Y490	HPRD; MINT
P05107	Q9Y4G6	MINT

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction