Tag | Content |
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UniProt Accession | ITB3_HUMAN; P05106; |
Entrez ID | 3690 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) |
Gene Name | ITGB3; GP3A |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen ga(view all) |
Sequence (Fasta) | MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG 60 SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP 120 DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG 180 AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR 240 NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH 300 VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS 360 MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT 420 VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT 480 FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG 540 KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL 600 CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY 660 CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL 720 VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF 780 TNITYRGT 789 |
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Database | Annotation |
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CTD (Curated) (count: 17) (view all) | MESH:D054058
; Acute Coronary Syndrome MESH:D000067877 ; Autism Spectrum Disorder MESH:D001321 ; Autistic Disorder MESH:D002341 ; Carotid Artery Thrombosis MESH:D002543 ; Cerebral Hemorrhage MESH:D003328 ; Coronary Thrombosis |
DisGeNet (Curated) (count: 35) (view all) | C0002871; Anemia
C0004352; Autistic Disorder C0007274; Carotid Artery Thrombosis C0010072; Coronary Thrombosis C0013491; Ecchymosis C0014591; Epistaxis |
HGMD (count: 81) (view all) | CP931379; Glanzmann thrombasthenia; Complex rearrangements
CD021199; Glanzmann thrombasthenia; Small deletions CD054963; Glanzmann thrombasthenia; Small deletions CD087462; Glanzmann thrombasthenia; Small deletions CD066369; Glanzmann thrombasthenia; Small deletions CD020346; Thrombocytopaenia; Small deletions |
GWASdb (count: 19) (view all) | rs2317385; Waist-Hip Ratio; obesity
rs2317385; Lung function (forced expiratory volume in 1 second); lung disease rs10514919; Lung function (forced expiratory flow between 25% and 75% of forced vital capacity); lung disease rs10514919; Response to alcohol consumption (flushing response); alcohol abuse|alcohol dependence rs11657517; Multiple complex diseases; Null rs3851806; Coronary artery calcification; coronary artery disease |
PTM | Modification Sites |
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Phosphorylation (count: 7) (view all) | 767 RARAKWDTANNPLYK dbPAF
773 DTANNPLYKEATSTF dbPAF 777 NPLYKEATSTFTNIT dbPAF 778 PLYKEATSTFTNITY dbPAF 779 LYKEATSTFTNITYR dbPAF 784 TSTFTNITYRGT*** dbPAF |
Glycation (count: 2) | 438 GCPQEKEKSFTIKPV PLMD
669 RDEIESVKELKDTGK PLMD |
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