P05106

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession ITB3_HUMAN; P05106;
Entrez ID 3690
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
Gene Name ITGB3; GP3A
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionIntegrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen ga(view all)
Sequence
(Fasta)
MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG 60
SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP 120
DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG 180
AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR 240
NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH 300
VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS 360
MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT 420
VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT 480
FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG 540
KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL 600
CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY 660
CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL 720
VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF 780
TNITYRGT 789

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationGastric cancerP23857544
[Reference]: Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin 1 and 3

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 17)
(view all)
MESH:D054058 ; Acute Coronary Syndrome
MESH:D000067877 ; Autism Spectrum Disorder
MESH:D001321 ; Autistic Disorder
MESH:D002341 ; Carotid Artery Thrombosis
MESH:D002543 ; Cerebral Hemorrhage
MESH:D003328 ; Coronary Thrombosis
DisGeNet (Curated)
(count: 35)
(view all)
C0002871; Anemia
C0004352; Autistic Disorder
C0007274; Carotid Artery Thrombosis
C0010072; Coronary Thrombosis
C0013491; Ecchymosis
C0014591; Epistaxis
HGMD
(count: 81)
(view all)
CP931379; Glanzmann thrombasthenia; Complex rearrangements
CD021199; Glanzmann thrombasthenia; Small deletions
CD054963; Glanzmann thrombasthenia; Small deletions
CD087462; Glanzmann thrombasthenia; Small deletions
CD066369; Glanzmann thrombasthenia; Small deletions
CD020346; Thrombocytopaenia; Small deletions
GWASdb
(count: 19)
(view all)
rs2317385; Waist-Hip Ratio; obesity
rs2317385; Lung function (forced expiratory volume in 1 second); lung disease
rs10514919; Lung function (forced expiratory flow between 25% and 75% of forced vital capacity); lung disease
rs10514919; Response to alcohol consumption (flushing response); alcohol abuse|alcohol dependence
rs11657517; Multiple complex diseases; Null
rs3851806; Coronary artery calcification; coronary artery disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 7)
(view all)
767       RARAKWDTANNPLYK     dbPAF
773       DTANNPLYKEATSTF     dbPAF
777       NPLYKEATSTFTNIT     dbPAF
778       PLYKEATSTFTNITY     dbPAF
779       LYKEATSTFTNITYR     dbPAF
784       TSTFTNITYRGT***     dbPAF
Glycation
(count: 2)
438       GCPQEKEKSFTIKPV     PLMD
669       RDEIESVKELKDTGK     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
E7ESA6P05106HPRD
E9PGI4P05106MINT
O14924P05106MINT
O15530P05106HPRD
O75553P05106MINT;HPRD
P02671P05106HPRD
P02679P05106HPRD
P02751P05106IntAct;HPRD
P04004P05106HPRD
P04216P05106HPRD
P05106P05106HPRD; IntAct
P05106P06756HPRD; IntAct; MINT
P05106P07384HPRD
P05106P07947MINT
P05106P07948MINT
P05106P07996HPRD
P05106P08123HPRD
P05106P08514HPRD; DIP; IntAct; MINT
P05106P08648HPRD
P05106P09619HPRD
P05106P12931HPRD;MINT
P05106P14543HPRD
P05106P16234HPRD
P05106P16284HPRD
P05106P16671HPRD
P05106P18031MINT
P05106P21980HPRD
P05106P23471IntAct
P05106P29353HPRD
P05106P31749HPRD
P05106P35568MINT
P05106P35968HPRD
P05106P41231HPRD
P05106P49757HPRD; MINT
P05106P98082HPRD; MINT
P05106P98095HPRD
P05106Q02410MINT
P05106Q12929HPRD; MINT
P05106Q13352HPRD
P05106Q13418HPRD
P05106Q14289HPRD
P05106Q63HR2MINT;HPRD
P05106Q7Z6G8MINT
P05106Q92529MINT
P05106Q99704HPRD; MINT
P05106Q99767MINT
P05106Q9UBP9MINT
P05106Q9UQF2MINT
P05106Q9Y3P9MINT
P05106Q9Y490HPRD; MINT
P05106Q9Y5C1HPRD