| Tag | Content |
|---|---|
| UniProt Accession | HSPB1_HUMAN; P04792; |
| Entrez ID | 3315 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) |
| Gene Name | HSPB1; HSP27; HSP28 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). |
| Sequence (Fasta) | MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP 60 AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI 120 TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT 180 IPVTFESRAQ LGGPEAAKSD ETAAK 206 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 19) (view all) | MESH:C538231
; Adenocarcinoma of lung MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002292 ; Carcinoma, Renal Cell MESH:D002294 ; Carcinoma, Squamous Cell MESH:D002312 ; Cardiomyopathy, Hypertrophic MESH:C535413 ; Charcot-Marie-Tooth disease, Type 2F |
| DisGeNet (Curated) (count: 47) (view all) | C0007134; Renal Cell Carcinoma
C0007137; Squamous cell carcinoma C0007194; Hypertrophic Cardiomyopathy C0009375; Colonic Neoplasms C0011616; Contact Dermatitis C0015644; Muscular fasciculation |
| HGMD (count: 12) (view all) | CM086474; Distal motor neuropathy / Charcot-Marie-Tooth disease 2 ?; Missense/nonsense
CM084860; Neuropathy, distal hereditary motor; Missense/nonsense CM085982; Distal motor neuropathy / Charcot-Marie-Tooth disease 2; Missense/nonsense CM041372; Neuropathy, distal hereditary motor; Missense/nonsense CM041373; Charcot-Marie-Tooth disease, axonal, type 2F; Missense/nonsense CM041374; Charcot-Marie-Tooth disease, axonal, type 2F; Missense/nonsense |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 39) (view all) | 110 HFAPDELTVKTKDGV dbPAF
113 PDELTVKTKDGVVEI dbPAF 121 KDGVVEITGKHEERQ dbPAF 133 ERQDEHGYISRCFTR dbPAF 135 QDEHGYISRCFTRKY dbPAF 139 GYISRCFTRKYTLPP dbPAF |
| Acetylation (count: 5) | 112 APDELTVKTKDGVVE PLMD
114 DELTVKTKDGVVEIT PLMD 123 GVVEITGKHEERQDE PLMD 141 ISRCFTRKYTLPPGV PLMD 198 LGGPEAAKSDETAAK PLMD |
| Ubiquitination (count: 6) | 112 APDELTVKTKDGVVE PLMD
114 DELTVKTKDGVVEIT PLMD 123 GVVEITGKHEERQDE PLMD 141 ISRCFTRKYTLPPGV PLMD 171 TVEAPMPKLATQSNE PLMD 198 LGGPEAAKSDETAAK PLMD |
| Sumoylation (count: 2) | 114 DELTVKTKDGVVEIT PLMD
198 LGGPEAAKSDETAAK PLMD |
| Glycation (count: 2) | 114 DELTVKTKDGVVEIT PLMD
123 GVVEITGKHEERQDE PLMD |
| Malonylation (count: 4) | 112 APDELTVKTKDGVVE PLMD
114 DELTVKTKDGVVEIT PLMD 123 GVVEITGKHEERQDE PLMD 198 LGGPEAAKSDETAAK PLMD |