P04637

※ Protein Information

Tag	Content
UniProt Accession	P53_HUMAN; P04637;
Entrez ID	7157
GenBank Protein ID	NM_000546.5; NM_001126112.2; NM_001126113.2; NM_001126114.2; NM_001126115.1; NM_001126116.1; NM_001126117.1; NM_001126118.1; NM_001276695.1; NM_001276696.1; NM_001276697.1; NM_001276698.1; NM_001276699.1; NM_001276760.1; NM_001276761.1;
GenBank Nucleotide ID	NP_000537.3; NP_001119584.1; NP_001119585.1; NP_001119586.1; NP_001119587.1; NP_001119588.1; NP_001119589.1; NP_001119590.1; NP_001263624.1; NP_001263625.1; NP_001263626.1; NP_001263627.1; NP_001263628.1; NP_001263689.1; NP_001263690.1;
Protein Name	Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene Name	TP53; P53
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF i(view all) Functional Description Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Sequence (Fasta)	MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP 60 DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK 120 SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE 180 RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS 240 SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP 300 PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG 360 GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD 394 Fasta Sequence >P04637\|TP53; P53\|Homo sapiens (Human) MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Acetylation	Breast cancer/tumor/carcinoma		D		24920214
1	[Reference]: Our results provide evidence that melatonin enhances p53 acetylation by modulating the MDM2/MDMX/p300 pathway, disclosing new insights for understanding its anticancer effect.
2	Ubiquitination	Gastric cancer		P		24240108
2	[Reference]: Collectively, our novel findings indicate that AURKA promotes tumor growth and cell survival through regulation of HDM2-induced ubiquitination and inhibition of P53
3	Phosphorylation	Pancreatic cancer/carcinoma/adenocarcinoma		P		23845906
3	[Reference]: Here, we found that cisplatin mainly induced non-apoptotic death of the pancreatic cancer cells (AsPC-1 and Capan-2), which was associated with a significant p53 activation (phosphorylation and accumulation).
4	Phosphorylation	Head and neck squamous cell carcinoma		P		23414419
4	[Reference]: P276-00 treatment suppressed cell proliferation through inhibition of CCND1 expression, reduced phosphorylation of retinoblastoma protein and abrogative transcription of E2F1 gene targets
5	Phosphorylation	Melanoma	A375 cell line	P		22968364
5	[Reference]: Ruthenium complexes containing 2,6-bis(benzimidazolyl)pyridine derivatives induce cancer cell apoptosis by triggering DNA damage-mediated p53 phosphorylation
6	Ubiquitination	Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma		U		16581249
6	[Reference]: Gankyrin regulates the phosphorylation of the retinoblastoma protein (pRb) by CDK4 and enhances the ubiquitylation of p53 by the RING ubiquitin ligase MDM3.
7	Serine Phosphorylation	Breast cancer/tumor/carcinoma	MCF7	A	S15	15958581; 23798621
7	[Reference]: DACH1 phosphorylation at serine residue (S439) inhibited p53 binding and phosphorylation at p53 amino-terminal sites (S15, S20) enhanced DACH1 binding. DACH1 binding to p53 was inhibited by NAD-dependent deacetylation via DACH1 K628. DACH1 repressed p21CIP1 and induced RAD51, an association found in basal breast cancer. DACH1 inhibits breast cancer cellular growth in an NAD and p53-dependent manner through direct protein-protein association.
8	Serine Phosphorylation	Ataxia-telangiectasic cancer		D	S15	9733515
8	[Reference]: Ionizing radiation, but not ultraviolet radiation, rapidly enhanced this p53-directed kinase activity of endogenous ATM. These observations, along with the fact that phosphorylation of p53 on serine-15 in response to ionizing radiation is reduced in ataxia telangiectasia cells, suggest that ATM is a protein kinase that phosphorylates p53 in vivo.
9	Serine Phosphorylation	Brain cancer/tumor	GBM8401 cell line	D	S15	23268709
9	[Reference]: P. indica root aqueous extracts suppress cancer cell proliferation and migration through the phosphorylated-p53 and p21 pathways
10	Serine Phosphorylation	Prostate cancer/carcinoma/adenocarcinoma	cell line	P	S15	23359208
10	[Reference]: AA can activate p53 through increasing the phosphorylation of p53 on Ser15 in LNCaP cells
11	Serine Phosphorylation	Down syndrome		U	S15	20696760
11	[Reference]: Accordingly, brains from embryonic DYRK1A transgenic mice exhibited elevated levels of Dyrk1A, Ser-15 (mouse Ser-18)-phosphorylated p53, and p21(CIP1) as well as impaired neuronal proliferation.
12	Serine Phosphorylation	Colon cancer/carcinoma	cell line	U	S15	25860929
12	[Reference]: FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15.
13	Serine Phosphorylation	Neuroblastoma		U	S15	23824039
13	[Reference]: MPTQ-mediated apoptosis is associated with increased phosphorylation of p53 at Ser15 and Ser20 which correlates with the hyperphosphorylation of Ataxia-Telangiectasia mutated protein (ATM)
14	Serine Phosphorylation	Breast cancer/tumor/carcinoma	MCF7	A	S20	23798621
14	[Reference]: DACH1 phosphorylation at serine residue (S439) inhibited p53 binding and phosphorylation at p53 amino-terminal sites (S15, S20) enhanced DACH1 binding. DACH1 binding to p53 was inhibited by NAD-dependent deacetylation via DACH1 K628. DACH1 repressed p21CIP1 and induced RAD51, an association found in basal breast cancer. DACH1 inhibits breast cancer cellular growth in an NAD and p53-dependent manner through direct protein-protein association.
15	Serine Phosphorylation	Ovarian cancer/carcinoma		U	S20	20009884
15	[Reference]: In p53-positive ovarian carinomas, S392 phosphorylation was associated with advanced tumor stage and high tumor grade. S20 phosphorylation was associated with low tumor grade in p53-positive, and high tumor grade in p53-negative, ovarian carcinomas.
16	Serine Phosphorylation	Neuroblastoma		U	S20	23824039
16	[Reference]: MPTQ-mediated apoptosis is associated with increased phosphorylation of p53 at Ser15 and Ser20 which correlates with the hyperphosphorylation of Ataxia-Telangiectasia mutated protein (ATM)
17	Serine Phosphorylation	B-cell tumor		A	S23	15343266
17	[Reference]: Our finding that S23A/S23A animals are tumor prone suggests that Ser23 phosphorylation is important for the tumor suppressor function of p53.
18	Serine Phosphorylation	T cell lymphoma		N	S37	11042698
18	[Reference]: A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line.
19	Serine Phosphorylation	Breast cancer/tumor/carcinoma	MCF7	D	S46	17404016
19	[Reference]: Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells
20	Serine Phosphorylation	Acute lymphoblastic leukaemia		D	S46	23717325; 16377624
20	[Reference]: TP53INP1 Functions as a Tumor Suppressor and Induces Apoptosis through Phosphorylating p53 at Serine-46
21	Serine Phosphorylation	Huntington's disease		U	S46	22011578
21	[Reference]: Mass spectrometry analysis of the post-translational modifications of alpha-enolase from pancreatic ductal adenocarcinoma cells.
22	Arginine Methylation	Lung cancer/carcinoma	H1299 cell line	P	R213	24384472
22	[Reference]: It has been reported that p53 with R213Q mutation is exist in certain tumor cell lines and its methylation on R213 as well
23	Serine Phosphorylation	Lymphoma		D	S312	24173284
23	[Reference]: Our study shows that in addition to protecting against tumours caused by ionising radiation, phosphorylation of p53 on Ser312 also contributes to the suppression of carcinogen-mediated tumourigenesis
24	Lysine Methylation	Glioblastoma		P	K370	22864287
24	[Reference]: We also found that endogenous full-length PHF20 interacted with endogenous p53 in cell lines U87 (glioblastoma) and MCF7 (breast cancer), which both express wild-type p53; PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
25	Lysine Methylation	Breast cancer/tumor/carcinoma	MCF7	P	K370	22864287
25	[Reference]: We also found that endogenous full-length PHF20 interacted with endogenous p53 in cell lines U87 (glioblastoma) and MCF7 (breast cancer), which both express wild-type p53; PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
26	Lysine Methylation	Lymphoma		D	K372	24189068
26	[Reference]: We also show that reduced PRMT5 expression leads to cyclin D1 transcriptional repression via loss of TP53K372 methylation, which results in decreased BCL3 expression and enhanced recruitment of NF-B p52-HDAC1 repressor complexes to the cyclin D1 promoter.
27	Serine Phosphorylation	Breast cancer/tumor/carcinoma	MCF7	A	S392	21084272
27	[Reference]: lack of phosphorylation at Ser392 may be important in breast cancer pathogenesis and inability to phosphorylate p53 at this site has been related to treatment response
28	Serine Phosphorylation	Vestibular schwannomas		P	S392	16299809
28	[Reference]: Our results suggest that age dependent phosphorylation of p53 protein and deregulation of p53 gene has a role in the development of human vestibular schwannomas.
29	Serine Phosphorylation	Ovarian cancer/carcinoma		U	S392	20009884
29	[Reference]: Expression of p53 protein phosphorylated at serine 20 and serine 392 in malignant and benign ovarian neoplasms: correlation with clinicopathological parameters of tumors.
30	Serine Phosphorylation	Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma		U	S392	21455220
30	[Reference]: Met ensures cell survival through a new path in which c-Abl and p38-MAPK are employed to elicit p53 phosphorylation on Ser(392) and Mdm2 upregulation. We found a clinical correlation between activated Met, phospho-p53, and Mdm2 levels in human tumors, supporting the role of this path in tumorigenesis.

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association