Tag | Content |
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UniProt Accession | SHBG_HUMAN; P04278; |
Entrez ID | 6462 |
GenBank Protein ID | NM_001040.4; NM_001146279.2; NM_001146280.2; NM_001146281.2; NM_001289113.1; NM_001289114.1; NM_001289115.1; NM_001289116.1; |
GenBank Nucleotide ID | NP_001031.2; NP_001139751.1; NP_001139752.1; NP_001139753.1; NP_001276042.1; NP_001276043.1; NP_001276044.1; NP_001276045.1; |
Protein Name | Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin) |
Gene Name | SHBG |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. |
Sequence (Fasta) | MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT 60 FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA 120 GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS 180 NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI 240 PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL 300 VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS 360 FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SH 403 |
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Database | Annotation |
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CTD (Curated) (count: 7) (view all) | MESH:D000437
; Alcoholism MESH:D003924 ; Diabetes Mellitus, Type 2 MESH:D007172 ; Erectile Dysfunction MESH:D008207 ; Lymphatic Metastasis MESH:D024821 ; Metabolic Syndrome MESH:D009361 ; Neoplasm Invasiveness |
HGMD (count: 4) | CE040651; Polycystic ovary syndrome, association with; Repeat variations
CD021440; Hyperandrogenism; Small deletions CM021325; Hyperandrogenism; Missense/nonsense CM994728; Breast cancer, oestrogen-dependence, assoc. with ?; Missense/nonsense |
GWASdb (count: 6) | rs12150660; Testosterone levels; breast cancer
rs12150660; Sex hormone-binding globulin levels; breast cancer rs1799941; Response to cytadine analogues (cytosine arabinoside); cancer rs6258; Testosterone levels; breast cancer rs6258; Sex hormone-binding globulin levels; breast cancer rs6259; Colorectal cancer; colorectal cancer |
PTM | Modification Sites |
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Phosphorylation (count: 5) | 161 RQVSGPLTSKRHPIM dbPAF
162 QVSGPLTSKRHPIMR dbPAF 3 *****MESRGPLATS dbPAF 72 KITKTSSSFEVRTWD dbPAF 86 DPEGVIFYGDTNPKD dbPAF |
Glycation (count: 3) | 163 VSGPLTSKRHPIMRI PLMD
202 RRDSWLDKQAEISAS PLMD 322 VVLSQGSKMKALALP PLMD |
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