P04278

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession SHBG_HUMAN; P04278;
Entrez ID 6462
GenBank Protein ID NM_001040.4; NM_001146279.2; NM_001146280.2; NM_001146281.2; NM_001289113.1; NM_001289114.1; NM_001289115.1; NM_001289116.1;
GenBank Nucleotide ID NP_001031.2; NP_001139751.1; NP_001139752.1; NP_001139753.1; NP_001276042.1; NP_001276043.1; NP_001276044.1; NP_001276045.1;
Protein Name Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin)
Gene Name SHBG
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionFunctions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Sequence
(Fasta)
MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT 60
FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA 120
GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS 180
NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI 240
PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL 300
VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS 360
FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SH 403

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1N-linked glycosylationBreast cancer/tumor/carcinomaNN327(356)18437557
[Reference]: A common single nucleotide polymorphism in the human SHBG gene results in an amino acid substitution (Asp327Asn), which introduces an additional N-glycosylation site, and is associated with reduced breast cancer risk in postmenopausal women.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 7)
(view all)
MESH:D000437 ; Alcoholism
MESH:D003924 ; Diabetes Mellitus, Type 2
MESH:D007172 ; Erectile Dysfunction
MESH:D008207 ; Lymphatic Metastasis
MESH:D024821 ; Metabolic Syndrome
MESH:D009361 ; Neoplasm Invasiveness
HGMD
(count: 4)
CE040651; Polycystic ovary syndrome, association with; Repeat variations
CD021440; Hyperandrogenism; Small deletions
CM021325; Hyperandrogenism; Missense/nonsense
CM994728; Breast cancer, oestrogen-dependence, assoc. with ?; Missense/nonsense
GWASdb
(count: 6)
rs12150660; Testosterone levels; breast cancer
rs12150660; Sex hormone-binding globulin levels; breast cancer
rs1799941; Response to cytadine analogues (cytosine arabinoside); cancer
rs6258; Testosterone levels; breast cancer
rs6258; Sex hormone-binding globulin levels; breast cancer
rs6259; Colorectal cancer; colorectal cancer

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 5)
161       RQVSGPLTSKRHPIM     dbPAF
162       QVSGPLTSKRHPIMR     dbPAF
3         *****MESRGPLATS     dbPAF
72        KITKTSSSFEVRTWD     dbPAF
86        DPEGVIFYGDTNPKD     dbPAF
Glycation
(count: 3)
163       VSGPLTSKRHPIMRI     PLMD
202       RRDSWLDKQAEISAS     PLMD
322       VVLSQGSKMKALALP     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
A8MTH6P04278HPRD
B3KSH1P04278HPRD
E9PF99P04278HPRD
H0YGH4P04278HPRD
O14493P04278HPRD
O15523P04278HPRD
O75352P04278HPRD
O75955P04278HPRD
O95295P04278HPRD
O95782P04278HPRD
P02795P04278HPRD
P04278P04278HPRD
P04278P04733HPRD
P04278P07339HPRD
P04278P08123HPRD
P04278P0C869HPRD
P04278P13640HPRD
P04278P13798HPRD
P04278P14618HPRD
P04278P15309HPRD
P04278P17661HPRD
P04278P21333HPRD
P04278P25705HPRD
P04278P27694BioGRID
P04278P41222HPRD
P04278P50748BioGRID
P04278P54819HPRD
P04278P57057HPRD
P04278P60709HPRD
P04278P60981HPRD
P04278P62736HPRD
P04278P62993IntAct
P04278P63267HPRD
P04278P68104HPRD
P04278Q00796HPRD
P04278Q04941HPRD
P04278Q05086HPRD
P04278Q10567HPRD
P04278Q13275HPRD
P04278Q14582HPRD
P04278Q15155HPRD
P04278Q495Z4HPRD
P04278Q5D1E8HPRD
P04278Q6UXB4IntAct
P04278Q8N6Q3HPRD
P04278Q8NCR6HPRD
P04278Q96G75HPRD
P04278Q96QD9HPRD
P04278Q9BXW7HPRD
P04278Q9C0C9HPRD
P04278Q9H939HPRD
P04278Q9NRW3HPRD
P04278Q9Y5K2HPRD