P04198

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	MYCN_HUMAN; P04198;
Entrez ID	4613
GenBank Protein ID	NM_001293228.1; NM_001293231.1; NM_001293233.1; NM_005378.5; XM_017004168.1;
GenBank Nucleotide ID	NP_001280157.1; NP_001280160.1; NP_001280162.1; NP_005369.2; XP_016859657.1;
Protein Name	N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
Gene Name	MYCN; BHLHE37; NMYC
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Positively regulates the transcription of MYCNOS in neuroblastoma cells. Functional Description Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Sequence (Fasta)	MPSCSTSTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW KKFELLPTPP 60 LSPSRGFAEH SSEPPSWVTE MLLENELWGS PAEEDAFGLG GLGGLTPNPV ILQDCMWSGF 120 SAREKLERAV SEKLQHGRGP PTAGSTAQSP GAGAASPAGR GHGGAAGAGR AGAALPAELA 180 HPAAECVDPA VVFPFPVNKR EPAPVPAAPA SAPAAGPAVA SGAGIAAPAG APGVAPPRPG 240 GRQTSGGDHK ALSTSGEDTL SDSDDEDDEE EDEEEEIDVV TVEKRRSSSN TKAVTTFTIT 300 VRPKNAALGP GRAQSSELIL KRCLPIHQQH NYAAPSPYVE SEDAPPQKKI KSEASPRPLK 360 SVIPPKAKSL SPRNSDSEDS ERRRNHNILE RQRRNDLRSS FLTLRDHVPE LVKNEKAAKV 420 VILKKATEYV HSLQAEEHQL LLEKEKLQAR QQQLLKKIEH ARTC 465 Fasta Sequence >P04198\|MYCN; BHLHE37; NMYC\|Homo sapiens (Human) MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Phosphorylation	Neuroblastoma		P		1923500
1	[Reference]: The MYCN protein of human neuroblastoma cells is phosphorylated by casein kinase II in the central region and at serine 367

※ Disease Cross-ref Annotation

Database	Annotation
Cancer Gene Census	neuroblastoma
CTD (Curated) (count: 12) (view all)	MESH:D003528 ; Carcinoma, Adenoid Cystic MESH:D002280 ; Carcinoma, Basal Cell MESH:D002471 ; Cell Transformation, Neoplastic MESH:D002869 ; Chromosome Aberrations MESH:C531835 ; Esophageal atresia with or without tracheoesophageal fistula MESH:D006965 ; Hyperplasia MESH:D054218 ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma MESH:D008527 ; Medulloblastoma MESH:D009336 ; Necrosis MESH:D009447 ; Neuroblastoma MESH:C537734 ; Oculodigitoesophagoduodenal syndrome MESH:D009396 ; Wilms Tumor
HGMD (count: 29) (view all)	CD056824; Feingold syndrome; Small deletions CD056825; Feingold syndrome; Small deletions CD056826; Feingold syndrome; Small deletions CD056827; Feingold syndrome; Small deletions CD084163; Feingold syndrome; Small deletions CD084164; Feingold syndrome; Small deletions CG056918; Feingold syndrome; Gross deletions CG084510; Feingold syndrome; Gross deletions CG084511; Feingold syndrome; Gross deletions CG084512; Feingold syndrome; Gross deletions CI056883; Feingold syndrome; Small insertions CI084292; Feingold syndrome; Small insertions CI084293; Feingold syndrome; Small insertions CI084294; Feingold syndrome; Small insertions CI056884; Feingold syndrome; Small insertions CI084295; Feingold syndrome; Small insertions CI084296; Feingold syndrome; Small insertions CI056885; Feingold syndrome; Small insertions CM083732; Feingold syndrome; Missense/nonsense CM083735; Feingold syndrome; Missense/nonsense CM083733; Feingold syndrome; Missense/nonsense CM083734; Feingold syndrome; Missense/nonsense CM056654; Feingold syndrome; Missense/nonsense CM056655; Feingold syndrome; Missense/nonsense CM083545; Feingold syndrome; Missense/nonsense CM056656; Feingold syndrome; Missense/nonsense CM056658; Feingold syndrome; Missense/nonsense CM056657; Feingold syndrome; Missense/nonsense CM083731; Feingold syndrome; Missense/nonsense

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 12) (view all)	156 SPGAGAASPAGRGHG dbPAF 261 TSGEDTLSDSDDEDD dbPAF 263 GEDTLSDSDDEDDEE dbPAF 3 ***MPSCSTSTMP dbPAF 355 KKIKSEASPRPLKSV dbPAF 5 MPSCSTSTMPGM dbPAF 58 KKFELLPTPPLSPSR dbPAF 6 MPSCSTSTMPGMI dbPAF 62 LLPTPPLSPSRGFAE dbPAF 64 PTPPLSPSRGFAEHS dbPAF 7 MPSCSTSTMPGMIC dbPAF 8 MPSCSTSTMPGMICK dbPAF
Acetylation (count: 1)	133 LERAVSEKLQHGRGP PLMD
Ubiquitination (count: 1)	52 PGEDIWKKFELLPTP PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

O14965	P04198	IntAct
P04198	P08047	IntAct
P04198	P19784	HPRD
P04198	P49841	IntAct
P04198	P61244	HPRD; IntAct
P04198	P68400	HPRD
P04198	Q05195	HPRD
P04198	Q13287	HPRD; IntAct
P04198	Q8IY57	HPRD
P04198	Q8N726	MINT
P04198	Q92769	IntAct
P04198	Q969H0	IntAct
P04198	Q96EB6	IntAct