Tag | Content |
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UniProt Accession | GCR_HUMAN; P04150; |
Entrez ID | 2908 |
GenBank Protein ID | NM_000176.2; NM_001018074.1; NM_001018075.1; NM_001018076.1; NM_001018077.1; NM_001020825.1; NM_001024094.1; NM_001204258.1; NM_001204259.1; NM_001204260.1; NM_001204261.1; NM_001204262.1; NM_001204263.1; NM_001204264.1; XM_005268419.3; XM_005268420.4; XM_005268422.3; XM_005268423.3; XM_017009397.1; XM_017009398.1; |
GenBank Nucleotide ID | NP_000167.1; NP_001018084.1; NP_001018085.1; NP_001018086.1; NP_001018087.1; NP_001018661.1; NP_001019265.1; NP_001191187.1; NP_001191188.1; NP_001191189.1; NP_001191190.1; NP_001191191.1; NP_001191192.1; NP_001191193.1; XP_005268476.1; XP_005268477.1; XP_005268479.1; XP_005268480.1; XP_016864886.1; XP_016864887.1; |
Protein Name | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) |
Gene Name | NR3C1; GRL |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the(view all) |
Sequence (Fasta) | MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR 60 LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK 120 LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN 180 VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN 240 SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV 300 YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG 360 SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL 420 CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GQHNYLCAGR NDCIIDKIRR KNCPACRYRK 480 CLQAGMNLEA RKTKKKIKGI QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE 540 PEVLYAGYDS SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW 600 MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS SELHRLQVSY 660 EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA IVKREGNSSQ NWQRFYQLTK 720 LLDSMHEVVE NLLNYCFQTF LDKTMSIEFP EMLAEIITNQ IPKYSNGNIK KLLFHQK 778 |
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Database | Annotation |
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CTD (Curated) (count: 13) (view all) | MESH:D058489
; 46, XX Disorders of Sex Development MESH:D001714 ; Bipolar Disorder MESH:D019970 ; Cocaine-Related Disorders MESH:D003866 ; Depressive Disorder MESH:D004715 ; Endometriosis MESH:C564221 ; Glucocorticoid Receptor Deficiency |
DisGeNet (Curated) (count: 33) (view all) | C0001969; Alcoholic Intoxication
C0005586; Bipolar Disorder C0011570; Mental Depression C0011581; Depressive disorder C0014175; Endometriosis C0015672; Fatigue |
HGMD (count: 20) (view all) | CD930996; Glucocorticoid receptor deficiency; Small deletions
CX025381; Reduced insulin and cholesterol levels, assoc.; Small indels CI015015; Lupus nephritis; Small insertions CM990712; Altered glucocorticoid sensitivity, association; Missense/nonsense CM980957; Increased glucocorticoid sensitivity, association; Missense/nonsense CM086885; Increased glucocorticoid sensitivity; Missense/nonsense |
GWASdb (count: 10) (view all) | rs852977; Drug response to Escitalopram; Null
rs852977; Drug response to Nortriptyline; Null rs17100234; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease rs2918415; Amyotrophic lateral sclerosis (sporadic); amyotrophic lateral sclerosis rs10066267; Parkinson's disease (interaction with coffee consumption); Parkinson's disease rs10482633; Drug response to Escitalopram; Null |
PTM | Modification Sites |
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Phosphorylation (count: 45) (view all) | 113 QQGQISLSSGETDLK dbPAF
125 DLKLLEESIANLNRS dbPAF 132 SIANLNRSTSVPENP dbPAF 133 IANLNRSTSVPENPK dbPAF 134 ANLNRSTSVPENPKS dbPAF 141 SVPENPKSSASTAVS dbPAF |
Acetylation (count: 3) | 154 VSAAPTEKEFPKTHS PLMD
494 NLEARKTKKKIKGIQ PLMD 495 LEARKTKKKIKGIQQ PLMD |
Ubiquitination (count: 5) | 498 RKTKKKIKGIQQATT PLMD
677 LLLSSVPKDGLKSQE PLMD 681 SVPKDGLKSQELFDE PLMD 695 EIRMTYIKELGKAIV PLMD 771 YSNGNIKKLLFHQK* PLMD |
Sumoylation (count: 8) (view all) | 254 PLILPDTKPKIKDNG PLMD
277 NVTLPQVKTEKEDFI PLMD 293 LCTPGVIKQEKLGTV PLMD 498 RKTKKKIKGIQQATT PLMD 57 VASQSDSKQRRLLVD PLMD 67 RLLVDFPKGSVSNAQ PLMD |