| Tag | Content |
|---|---|
| UniProt Accession | RAF1_HUMAN; P04049; |
| Entrez ID | 5894 |
| GenBank Protein ID | NM_002880.3; XM_005265355.2; XM_011533974.2; |
| GenBank Nucleotide ID | NP_002871.1; XP_005265412.1; XP_011532276.1; |
| Protein Name | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) |
| Gene Name | RAF1; RAF |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3(view all) |
| Sequence (Fasta) | MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD PSKTSNTIRV 60 FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLHEHKGKKA RLDWNTDAAS 120 LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 180 PTMCVDWSNI RQLLLFPNST IGDSGVPALP SLTMRRMRES VSRMPVSSQH RYSTPHAFTF 240 NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL 300 SPTGWSQPKT PVPAQRERAP VSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF 360 GTVYKGKWHG DVAVKILKVV DPTPEQFQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV 420 TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL 480 TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE 540 LMTGELPYSH INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP 600 QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF 649 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | pilocytic astrocytoma, prostate |
| CTD (Curated) (count: 15) (view all) | MESH:D001943
; Breast Neoplasms MESH:D002311 ; Cardiomyopathy, Dilated OMIM:615916 ; CARDIOMYOPATHY, DILATED, 1NN MESH:D002312 ; Cardiomyopathy, Hypertrophic MESH:D005910 ; Glioma MESH:D006930 ; Hyperalgesia |
| HGMD (count: 18) (view all) | CM073295; Noonan syndrome; Missense/nonsense
CM073301; Noonan syndrome; Missense/nonsense CM086899; Noonan syndrome; Missense/nonsense CM073300; Noonan syndrome; Missense/nonsense CM073288; Noonan syndrome; Missense/nonsense CM073290; Cardiomyopathy, hypertrophic; Missense/nonsense |
| GWASdb (count: 7) (view all) | rs3729931; Cardiac hypertrophy; hypertrophic cardiomyopathy
rs2290159; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs1532533; Arthritis (juvenile idiopathic); juvenile rheumatoid arthritis rs2442809; Multiple complex diseases; Null rs11705805; Suicide attempts in bipolar disorder; bipolar disorder rs2055312; Suicide attempts in bipolar disorder; bipolar disorder |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 64) (view all) | 211 SGVPALPSLTMRRMR dbPAF
213 VPALPSLTMRRMRES dbPAF 220 TMRRMRESVSRMPVS dbPAF 227 SVSRMPVSSQHRYST dbPAF 232 PVSSQHRYSTPHAFT dbPAF 233 VSSQHRYSTPHAFTF dbPAF |
| Acetylation (count: 2) | 144 TTHNFARKTFLKLAF PLMD
148 FARKTFLKLAFCDIC PLMD |
| Ubiquitination (count: 5) | 365 GSFGTVYKGKWHGDV PLMD
462 GMDYLHAKNIIHRDM PLMD 470 NIIHRDMKSNNIFLH PLMD 493 DFGLATVKSRWSGSQ PLMD 591 LVADCVKKVKEERPL PLMD |