| Tag | Content |
|---|---|
| UniProt Accession | TFR1_HUMAN; P02786; |
| Entrez ID | 7037 |
| GenBank Protein ID | NM_001128148.2; NM_001313965.1; NM_001313966.1; NM_003234.3; |
| GenBank Nucleotide ID | NP_001121620.1; NP_001300894.1; NP_001300895.1; NP_003225.2; |
| Protein Name | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] |
| Gene Name | TFRC |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).;(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. |
| Sequence (Fasta) | MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AVDEEENADN NTKANVTKPK 60 RCSGSICYGT IAVIVFFLIG FMIGYLGYCK GVEPKTECER LAGTESPVRE EPGEDFPAAR 120 RLYWDDLKRK LSEKLDSTDF TGTIKLLNEN SYVPREAGSQ KDENLALYVE NQFREFKLSK 180 VWRDQHFVKI QVKDSAQNSV IIVDKNGRLV YLVENPGGYV AYSKAATVTG KLVHANFGTK 240 KDFEDLYTPV NGSIVIVRAG KITFAEKVAN AESLNAIGVL IYMDQTKFPI VNAELSFFGH 300 AHLGTGDPYT PGFPSFNHTQ FPPSRSSGLP NIPVQTISRA AAEKLFGNME GDCPSDWKTD 360 STCRMVTSES KNVKLTVSNV LKEIKILNIF GVIKGFVEPD HYVVVGAQRD AWGPGAAKSG 420 VGTALLLKLA QMFSDMVLKD GFQPSRSIIF ASWSAGDFGS VGATEWLEGY LSSLHLKAFT 480 YINLDKAVLG TSNFKVSASP LLYTLIEKTM QNVKHPVTGQ FLYQDSNWAS KVEKLTLDNA 540 AFPFLAYSGI PAVSFCFCED TDYPYLGTTM DTYKELIERI PELNKVARAA AEVAGQFVIK 600 LTHDVELNLD YERYNSQLLS FVRDLNQYRA DIKEMGLSLQ WLYSARGDFF RATSRLTTDF 660 GNAEKTDRFV MKKLNDRVMR VEYHFLSPYV SPKESPFRHV FWGSGSHTLP ALLENLKLRK 720 QNNGAFNETL FRNQLALATW TIQGAANALS GDVWDIDNEF 761 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | NHL |
| CTD (Curated) (count: 21) (view all) | MESH:D000022
; Abortion, Spontaneous MESH:D018798 ; Anemia, Iron-Deficiency MESH:D001117 ; Arenaviridae Infections MESH:D017086 ; beta-Thalassemia MESH:D001943 ; Breast Neoplasms MESH:D002471 ; Cell Transformation, Neoplastic |
| HGMD (count: 1) | CM991171; Neoplastic disease, increased risk, association; Missense/nonsense
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| GWASdb (count: 34) (view all) | rs406271; Red blood cell traits; hematopoietic system disease
rs557527; Blood cell counts and traits, in red and white blood cells; hematopoietic system disease|Human immunodeficiency virus infectious disease|myocardial infarction rs557527; Red blood cell traits; hematopoietic system disease rs3326; Other erythrocyte phenotypes; hematopoietic system disease rs3326; Red blood cell traits; hematopoietic system disease rs3933; Red blood cell traits; hematopoietic system disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 25) (view all) | 10 DQARSAFSNLFGGEP dbPAF
104 ECERLAGTESPVREE dbPAF 106 ERLAGTESPVREEPG dbPAF 123 FPAARRLYWDDLKRK dbPAF 19 LFGGEPLSYTRFSLA dbPAF 195 VKIQVKDSAQNSVII dbPAF |
| Acetylation (count: 8) (view all) | 128 RLYWDDLKRKLSEKL PLMD
189 WRDQHFVKIQVKDSA PLMD 382 LTVSNVLKEIKILNI PLMD 394 LNIFGVIKGFVEPDH PLMD 418 AWGPGAAKSGVGTAL PLMD 514 EKTMQNVKHPVTGQF PLMD |
| Ubiquitination (count: 36) (view all) | 128 RLYWDDLKRKLSEKL PLMD
130 YWDDLKRKLSEKLDS PLMD 134 LKRKLSEKLDSTDFT PLMD 145 TDFTGTIKLLNENSY PLMD 161 PREAGSQKDENLALY PLMD 180 FREFKLSKVWRDQHF PLMD |
| Succinylation (count: 2) | 128 RLYWDDLKRKLSEKL PLMD
161 PREAGSQKDENLALY PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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