| Tag | Content |
|---|---|
| UniProt Accession | A1AG1_HUMAN; P02763; |
| Entrez ID | 5004 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1) |
| Gene Name | ORM1; AGP1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. |
| Sequence (Fasta) | MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDQIT GKWFYIASAF RNEEYNKSVQ 60 EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ RENGTISRYV GGQEHFAHLL 120 ILRDTKTYML AFDVNDEKNW GLSVYADKPE TTKEQLGEFY EALDCLRIPK SDVVYTDWKK 180 DKCEPLEKQH EKERKQEEGE S 202 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D017093 ; Liver Failure |
| GWASdb (count: 5) | rs150611042; Thrombin generation potential phenotypes; blood protein disease
rs116994374; Thrombin generation potential phenotypes; blood protein disease rs113354603; Thrombin generation potential phenotypes; blood protein disease rs10982156; End-stage coagulation; cerebrovascular disease|blood coagulation disease rs10982156; Thrombin generation potential phenotypes; blood protein disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 3) | 109 ENGTISRYVGGQEHF dbPAF
175 IPKSDVVYTDWKKDK dbPAF 65 SVQEIQATFFYFTPN dbPAF |
| Acetylation (count: 2) | 170 LDCLRIPKSDVVYTD PLMD
179 DVVYTDWKKDKCEPL PLMD |
| Glycation (count: 5) | 126 LLILRDTKTYMLAFD PLMD
148 GLSVYADKPETTKEQ PLMD 170 LDCLRIPKSDVVYTD PLMD 179 DVVYTDWKKDKCEPL PLMD 188 DKCEPLEKQHEKERK PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |