| Tag | Content |
|---|---|
| UniProt Accession | B3AT_HUMAN; P02730; |
| Entrez ID | 6521 |
| GenBank Protein ID | NM_000342.3; XM_005257593.4; |
| GenBank Nucleotide ID | NP_000333.1; XP_005257650.1; |
| Protein Name | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) |
| Gene Name | SLC4A1; AE1; DI; EPB3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. |
| Sequence (Fasta) | MEELQDDYED MMEENLEQEE YEDPDIPESQ MEEPAAHDTE ATATDYHTTS HPGTHKVYVE 60 LQELVMDEKN QELRWMEAAR WVQLEENLGE NGAWGRPHLS HLTFWSLLEL RRVFTKGTVL 120 LDLQETSLAG VANQLLDRFI FEDQIRPQDR EELLRALLLK HSHAGELEAL GGVKPAVLTR 180 SGDPSQPLLP QHSSLETQLF CEQGDGGTEG HSPSGILEKI PPDSEATLVL VGRADFLEQP 240 VLGFVRLQEA AELEAVELPV PIRFLFVLLG PEAPHIDYTQ LGRAAATLMS ERVFRIDAYM 300 AQSRGELLHS LEGFLDCSLV LPPTDAPSEQ ALLSLVPVQR ELLRRRYQSS PAKPDSSFYK 360 GLDLNGGPDD PLQQTGQLFG GLVRDIRRRY PYYLSDITDA FSPQVLAAVI FIYFAALSPA 420 ITFGGLLGEK TRNQMGVSEL LISTAVQGIL FALLGAQPLL VVGFSGPLLV FEEAFFSFCE 480 TNGLEYIVGR VWIGFWLILL VVLVVAFEGS FLVRFISRYT QEIFSFLISL IFIYETFSKL 540 IKIFQDHPLQ KTYNYNVLMV PKPQGPLPNT ALLSLVLMAG TFFFAMMLRK FKNSSYFPGK 600 LRRVIGDFGV PISILIMVLV DFFIQDTYTQ KLSVPDGFKV SNSSARGWVI HPLGLRSEFP 660 IWMMFASALP ALLVFILIFL ESQITTLIVS KPERKMVKGS GFHLDLLLVV GMGGVAALFG 720 MPWLSATTVR SVTHANALTV MGKASTPGAA AQIQEVKEQR ISGLLVAVLV GLSILMEPIL 780 SRIPLAVLFG IFLYMGVTSL SGIQLFDRIL LLFKPPKYHP DVPYVKRVKT WRMHLFTGIQ 840 IICLAVLWVV KSTPASLALP FVLILTVPLR RVLLPLIFRN VELQCLDADD AKATFDEEEG 900 RDEYDEVAMP V 912 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 10) (view all) | MESH:D000141
; Acidosis, Renal Tubular MESH:D000743 ; Anemia, Hemolytic MESH:D004612 ; Elliptocytosis, Hereditary MESH:D006402 ; Hematologic Diseases MESH:D008288 ; Malaria MESH:C566230 ; Ovalocytosis, Malaysian-Melanesian-Filipino Type |
| HGMD (count: 96) (view all) | CD972447; Spherocytosis; Small deletions
CD973100; Spherocytosis; Small deletions CD962155; Spherocytosis; Small deletions CD973099; Spherocytosis; Small deletions CD972450; Spherocytosis; Small deletions CD962154; Spherocytosis; Small deletions |
| GWASdb (count: 8) (view all) | rs2072081; Red blood cell traits; hematopoietic system disease
rs2857078; Red blood cell traits; hematopoietic system disease rs5023; Obesity-related traits; obesity rs5020; LDL cholesterol; atherosclerosis|coronary artery disease rs5020; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs28931583; Breast cancer(er negative); breast cancer |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 26) (view all) | 181 KPAVLTRSGDPSQPL dbPAF
194 PLLPQHSSLETQLFC dbPAF 21 ENLEQEEYEDPDIPE dbPAF 29 EDPDIPESQMEEPAA dbPAF 303 IDAYMAQSRGELLHS dbPAF 347 RELLRRRYQSSPAKP dbPAF |
| Glycation (count: 10) (view all) | 116 ELRRVFTKGTVLLDL PLMD
160 LLRALLLKHSHAGEL PLMD 174 LEALGGVKPAVLTRS PLMD 542 ETFSKLIKIFQDHPL PLMD 592 AMMLRKFKNSSYFPG PLMD 600 NSSYFPGKLRRVIGD PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |