| Tag | Content |
|---|---|
| UniProt Accession | FIBG_HUMAN; P02679; |
| Entrez ID | 2266 |
| GenBank Protein ID | NM_000509.5; NM_021870.2; |
| GenBank Nucleotide ID | NP_000500.2; NP_068656.2; |
| Protein Name | Fibrinogen gamma chain |
| Gene Name | FGG; PRO2061 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. |
| Sequence (Fasta) | MSWSLHPRNL ILYFYALLFL SSTCVAYVAT RDNCCILDER FGSYCPTTCG IADFLSTYQT 60 KVDKDLQSLE DILHQVENKT SEVKQLIKAI QLTYNPDESS KPNMIDAATL KSRKMLEEIM 120 KYEASILTHD SSIRYLQEIY NSNNQKIVNL KEKVAQLEAQ CQEPCKDTVQ IHDITGKDCQ 180 DIANKGAKQS GLYFIKPLKA NQQFLVYCEI DGSGNGWTVF QKRLDGSVDF KKNWIQYKEG 240 FGHLSPTGTT EFWLGNEKIH LISTQSAIPY ALRVELEDWN GRTSTADYAM FKVGPEADKY 300 RLTYAYFAGG DAGDAFDGFD FGDDPSDKFF TSHNGMQFST WDNDNDKFEG NCAEQDGSGW 360 WMNKCHAGHL NGVYYQGGTY SKASTPNGYD NGIIWATWKT RWYSMKKTTM KIIPFNRLTI 420 GEGQQHHLGG AKQVRPEHPA ETEYDSLYPE DDL 454 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 4) | MESH:D000347
; Afibrinogenemia MESH:C562727 ; Dysfibrinogenemia, Congenital MESH:D007627 ; Keloid MESH:D013274 ; Stomach Neoplasms |
| DisGeNet (Curated) (count: 14) (view all) | C0000786; Spontaneous abortion
C0014591; Epistaxis C0017181; Gastrointestinal Hemorrhage C0017565; Gingival Hemorrhage C0022548; Keloid C0038356; Stomach Neoplasms |
| HGMD (count: 77) (view all) | CD011167; Afibrinogenaemia; Small deletions
CD075416; Hypodysfibrinogenaemia; Small deletions CD057610; Hypofibrinogenaemia with hepatic storage; Small deletions CD072420; Afibrinogenaemia; Small deletions CD045343; Hypofibrinogenaemia; Small deletions CD910599; Dysfibrinogenaemia; Small deletions |
| GWASdb (count: 14) (view all) | rs2066865; Endometriosis; endometriosis
rs2066865; Venous thromboembolism; vein disease rs2066865; Venous thrombosis; Null rs2066865; Response to cytadine analogues (cytosine arabinoside); cancer rs2066865; Fibrinogen; cardiovascular system disease rs2066880; LDL cholesterol; atherosclerosis|coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 12) (view all) | 140 IRYLQEIYNSNNQKI dbPAF
288 GRTSTADYAMFKVGP dbPAF 300 VGPEADKYRLTYAYF dbPAF 374 AGHLNGVYYQGGTYS dbPAF 375 GHLNGVYYQGGTYSK dbPAF 379 GVYYQGGTYSKASTP dbPAF |
| Acetylation (count: 3) | 196 QSGLYFIKPLKANQQ PLMD
231 LDGSVDFKKNWIQYK PLMD 299 KVGPEADKYRLTYAY PLMD |
| Glycation (count: 22) (view all) | 101 YNPDESSKPNMIDAA PLMD
111 MIDAATLKSRKMLEE PLMD 114 AATLKSRKMLEEIMK PLMD 121 KMLEEIMKYEASILT PLMD 146 IYNSNNQKIVNLKEK PLMD 153 KIVNLKEKVAQLEAQ PLMD |
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