P02671

※ Protein Information

Tag	Content
UniProt Accession	FIBA_HUMAN; P02671;
Entrez ID	2243
GenBank Protein ID	NM_000508.4; NM_021871.3;
GenBank Nucleotide ID	NP_000499.1; NP_068657.1;
Protein Name	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]
Gene Name	FGA
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. Functional Description Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Sequence (Fasta)	MFSMRIVCLV LSVVGTAWTA DSGEGDFLAE GGGVRGPRVV ERHQSACKDS DWPFCSDEDW 60 NYKCPSGCRM KGLIDEVNQD FTNRINKLKN SLFEYQKNNK DSHSLTTNIM EILRGDFSSA 120 NNRDNTYNRV SEDLRSRIEV LKRKVIEKVQ HIQLLQKNVR AQLVDMKRLE VDIDIKIRSC 180 RGSCSRALAR EVDLKDYEDQ QKQLEQVIAK DLLPSRDRQH LPLIKMKPVP DLVPGNFKSQ 240 LQKVPPEWKA LTDMPQMRME LERPGGNEIT RGGSTSYGTG SETESPRNPS SAGSWNSGSS 300 GPGSTGNRNP GSSGTGGTAT WKPGSSGPGS TGSWNSGSSG TGSTGNQNPG SPRPGSTGTW 360 NPGSSERGSA GHWTSESSVS GSTGQWHSES GSFRPDSPGS GNARPNNPDW GTFEEVSGNV 420 SPGTRREYHT EKLVTSKGDK ELRTGKEKVT SGSTTTTRRS CSKTVTKTVI GPDGHKEVTK 480 EVVTSEDGSD CPEAMDLGTL SGIGTLDGFR HRHPDEAAFF DTASTGKTFP GFFSPMLGEF 540 VSETESRGSE SGIFTNTKES SSHHPGIAEF PSRGKSSSYS KQFTSSTSYN RGDSTFESKS 600 YKMADEAGSE ADHEGTHSTK RGHAKSRPVR DCDDVLQTHP SGTQSGIFNI KLPGSSKIFS 660 VYCDQETSLG GWLLIQQRMD GSLNFNRTWQ DYKRGFGSLN DEGEGEFWLG NDYLHLLTQR 720 GSVLRVELED WAGNEAYAEY HFRVGSEAEG YALQVSSYEG TAGDALIEGS VEEGAEYTSH 780 NNMQFSTFDR DADQWEENCA EVYGGGWWYN NCQAANLNGI YYPGGSYDPR NNSPYEIENG 840 VVWVSFRGAD YSLRAVRMKI RPLVTQ 867 Fasta Sequence >P02671\|FGA\|Homo sapiens (Human) MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Glycosylation	Dysfibrinogenemia	C	N158	1634621
1	[Reference]: The point mutation created an asparagine-X-serine-type glycosylation sequence, and indeed, extra, mainly disialylated biantennary oligosaccharides have been isolated from A asparagine-139 of the patient's fibrinogen.
2	Glycosylation	Dysfibrinogenemia	C	N453	1675636
2	[Reference]: We have identified a unique N-glycosylated Asn substitution for a Ser at position 434 of the A chain of an abnormal fibrinogen designated fibrinogen Caracas II.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 14) (view all)	MESH:D000347 ; Afibrinogenemia MESH:D028226 ; Amyloidosis, Familial MESH:C538249 ; Amyloidosis, familial visceral MESH:D056486 ; Chemical and Drug Induced Liver Injury MESH:D002779 ; Cholestasis MESH:D064420 ; Drug-Related Side Effects and Adverse Reactions MESH:C562727 ; Dysfibrinogenemia, Congenital MESH:D007674 ; Kidney Diseases MESH:D009062 ; Mouth Neoplasms MESH:D010024 ; Osteoporosis MESH:D011655 ; Pulmonary Embolism MESH:D019851 ; Thrombophilia MESH:D013927 ; Thrombosis MESH:D054556 ; Venous Thromboembolism
DisGeNet (Curated) (count: 36) (view all)	C0000786; Spontaneous abortion C0001733; Afibrinogenemia C0008370; Cholestasis C0013604; Edema C0014591; Epistaxis C0015230; Exanthema C0017181; Gastrointestinal Hemorrhage C0017565; Gingival Hemorrhage C0018965; Hematuria C0019209; Hepatomegaly C0020538; Hypertensive disease C0022658; Kidney Diseases C0026640; Mouth Neoplasms C0027726; Nephrotic Syndrome C0029456; Osteoporosis C0033687; Proteinuria C0034065; Pulmonary Embolism C0038002; Splenomegaly C0040053; Thrombosis C0041755; Adverse reaction to drug C0042487; Venous Thrombosis C0152031; Joint swelling C0232943; Intermenstrual heavy bleeding C0268389; Amyloidosis, familial visceral C0272350; Dysfibrinogenemia, Congenital C0398623; Thrombophilia C0497247; Increase in blood pressure C0553681; Hypofibrinogenemia C0740340; Amyloidosis, Familial C1408258; Kidney damage C1458140; Bleeding tendency C1861172; Venous Thromboembolism C1862968; Generalized amyloid deposition C2584774; Congenital hypofibrinogenemia C4020899; Autosomal recessive predisposition C4277682; Chemical and Drug Induced Liver Injury
HGMD (count: 87) (view all)	CD011165; Afibrinogenaemia; Small deletions CD072418; Afibrinogenaemia; Small deletions CD044976; Fibrinogen variant; Small deletions CD013642; Dysfibrinogenaemia; Small deletions CD035514; Fibrinogen variant; Small deletions CD001896; Afibrinogenaemia; Small deletions CD073641; Afibrinogenaemia; Small deletions CD001895; Afibrinogenaemia; Small deletions CD011163; Afibrinogenaemia; Small deletions CD011166; Afibrinogenaemia; Small deletions CD972214; Amyloidosis, renal; Small deletions CD011164; Afibrinogenaemia; Small deletions CD091544; Amyloidosis, renal; Small deletions CD962557; Dysfibrinogenaemia; Small deletions CD072419; Afibrinogenaemia; Small deletions CD962008; Amyloidosis, renal; Small deletions CG035206; Afibrinogenaemia; Gross deletions CG044344; Afibrinogenaemia; Gross deletions CG066710; Venous thromboembolism, suscep., association with; Gross deletions CG075796; Afibrinogenaemia; Gross deletions CG994916; Afibrinogenaemia; Gross deletions CN035518; Thrombosis; Gross insertions CX054515; Amyloidosis, renal; Small indels CX075725; Afibrinogenaemia; Small indels CX054516; Hypofibrinogenaemia; Small indels CI973068; Hypofibrinogenaemia; Small insertions CI942052; Dysfibrinogenaemia; Small insertions CI072573; Afibrinogenaemia; Small insertions CI035517; Afibrinogenaemia; Small insertions CI022295; Afibrinogenaemia; Small insertions CI001937; Afibrinogenaemia; Small insertions CI055751; Afibrinogenaemia; Small insertions CI010709; Dysfibrinogenaemia; Small insertions CM921008; Dysfibrinogenaemia; Missense/nonsense CM033774; Dysfibrinogenaemia; Missense/nonsense CM931189; Dysfibrinogenaemia; Missense/nonsense CM890186; Fibrinogen variant; Missense/nonsense CM013712; Afibrinogenaemia; Missense/nonsense CM003424; Fibrinogen variant; Missense/nonsense CM810009; Dysfibrinogenaemia; Missense/nonsense CM930249; Dysfibrinogenaemia; Missense/nonsense CM931190; Dysfibrinogenaemia; Missense/nonsense CM910607; Dysfibrinogenaemia; Missense/nonsense CM010045; Dysfibrinogenaemia; Missense/nonsense CM015839; Haemorrhages; Missense/nonsense CM950457; Dysfibrinogenaemia; Missense/nonsense CM085434; Hypofibrinogenaemia; Missense/nonsense CM073063; Afibrinogenaemia; Missense/nonsense CM010886; Afibrinogenaemia; Missense/nonsense CM013713; Afibrinogenaemia; Missense/nonsense CM067991; Hypofibrinogenaemia; Missense/nonsense CM013714; Afibrinogenaemia; Missense/nonsense CM053266; Afibrinogenaemia; Missense/nonsense CM001688; Afibrinogenaemia; Missense/nonsense CM067990; Afibrinogenaemia; Missense/nonsense CM071755; Afibrinogenaemia; Missense/nonsense CM065182; Afibrinogenaemia; Missense/nonsense CM071758; Afibrinogenaemia; Missense/nonsense CM071756; Afibrinogenaemia; Missense/nonsense CM067989; Dysfibrinogenaemia; Missense/nonsense CM071757; Afibrinogenaemia; Missense/nonsense CM001689; Afibrinogenaemia; Missense/nonsense CM994632; Increased post-stroke mortality, association with; Missense/nonsense CM001690; Afibrinogenaemia; Missense/nonsense CM063978; Fibrinogen variant; Missense/nonsense CM040741; Hypofibrinogenaemia; Missense/nonsense CM910608; Dysfibrinogenaemia; Missense/nonsense CM082670; Venous thromboembolism, suscep., association with; Missense/nonsense CM920272; Dysfibrinogenaemia; Missense/nonsense CM015840; Dysfibrinogenaemia; Missense/nonsense CM063979; Hypofibrinogenaemia; Missense/nonsense CM940775; Amyloidosis, renal; Missense/nonsense CM002014; Dysfibrinogenaemia; Missense/nonsense CM091541; Amyloidosis, renal; Missense/nonsense CM091542; Amyloidosis, renal; Missense/nonsense CM091543; Amyloidosis, renal; Missense/nonsense CM930251; Dysfibrinogenaemia; Missense/nonsense CM930250; Amyloidosis, renal; Missense/nonsense CR066662; Venous thromboembolism, suscep., association with; Regulatory CR016061; Venous thromboembolism, suscep., association with; Regulatory CR014259; Hypofibrinogenaemia; Regulatory CS001834; Afibrinogenaemia; Splicing CS055585; Afibrinogenaemia; Splicing CS090293; Hypofibrinogenaemia; Splicing CS053464; Hypofibrinogenaemia; Splicing CS072206; Afibrinogenaemia; Splicing CS001835; Afibrinogenaemia; Splicing
GWASdb (count: 4)	rs6050; Fibrinogen; cardiovascular system disease rs6050; Venous thromboembolism; vein disease rs6050; Venous thrombosis; Null rs2070016; Fibrinogen; cardiovascular system disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 55) (view all)	126 SANNRDNTYNRVSED dbPAF 127 ANNRDNTYNRVSEDL dbPAF 179 DIDIKIRSCRGSCSR dbPAF 185 RSCRGSCSRALAREV dbPAF 22 GTAWTADSGEGDFLA dbPAF 274 NEITRGGSTSYGTGS dbPAF 277 TRGGSTSYGTGSETE dbPAF 281 STSYGTGSETESPRN dbPAF 283 SYGTGSETESPRNPS dbPAF 290 TESPRNPSSAGSWNS dbPAF 291 ESPRNPSSAGSWNSG dbPAF 294 RNPSSAGSWNSGSSG dbPAF 297 SSAGSWNSGSSGPGS dbPAF 300 GSWNSGSSGPGSTGN dbPAF 356 PGSPRPGSTGTWNPG dbPAF 364 TGTWNPGSSERGSAG dbPAF 365 GTWNPGSSERGSAGH dbPAF 388 GSTGQWHSESGSFRP dbPAF 397 SGSFRPDSPGSGNAR dbPAF 400 FRPDSPGSGNARPNN dbPAF 412 PNNPDWGTFEEVSGN dbPAF 421 EEVSGNVSPGTRREY dbPAF 424 SGNVSPGTRREYHTE dbPAF 45 RVVERHQSACKDSDW dbPAF 451 TGKEKVTSGSTTTTR dbPAF 460 STTTTRRSCSKTVTK dbPAF 484 EVTKEVVTSEDGSDC dbPAF 485 VTKEVVTSEDGSDCP dbPAF 489 VVTSEDGSDCPEAMD dbPAF 499 PEAMDLGTLSGIGTL dbPAF 50 HQSACKDSDWPFCSD dbPAF 501 AMDLGTLSGIGTLDG dbPAF 505 GTLSGIGTLDGFRHR dbPAF 524 AAFFDTASTGKTFPG dbPAF 525 AFFDTASTGKTFPGF dbPAF 542 PMLGEFVSETESRGS dbPAF 544 LGEFVSETESRGSES dbPAF 546 EFVSETESRGSESGI dbPAF 549 SETESRGSESGIFTN dbPAF 551 TESRGSESGIFTNTK dbPAF 555 GSESGIFTNTKESSS dbPAF 557 ESGIFTNTKESSSHH dbPAF 56 DSDWPFCSDEDWNYK dbPAF 561 FTNTKESSSHHPGIA dbPAF 562 TNTKESSSHHPGIAE dbPAF 576 EFPSRGKSSSYSKQF dbPAF 577 FPSRGKSSSYSKQFT dbPAF 578 PSRGKSSSYSKQFTS dbPAF 588 KQFTSSTSYNRGDST dbPAF 594 TSYNRGDSTFESKSY dbPAF 609 KMADEAGSEADHEGT dbPAF 616 SEADHEGTHSTKRGH dbPAF 618 ADHEGTHSTKRGHAK dbPAF 626 TKRGHAKSRPVRDCD dbPAF 95 LKNSLFEYQKNNKDS dbPAF
Acetylation (count: 10) (view all)	148 LKRKVIEKVQHIQLL PLMD 167 RAQLVDMKRLEVDID PLMD 195 LAREVDLKDYEDQQK PLMD 210 QLEQVIAKDLLPSRD PLMD 227 HLPLIKMKPVPDLVP PLMD 243 NFKSQLQKVPPEWKA PLMD 448 ELRTGKEKVTSGSTT PLMD 476 VIGPDGHKEVTKEVV PLMD 558 SGIFTNTKESSSHHP PLMD 581 GKSSSYSKQFTSSTS PLMD
Glycation (count: 30) (view all)	100 FEYQKNNKDSHSLTT PLMD 144 RIEVLKRKVIEKVQH PLMD 148 LKRKVIEKVQHIQLL PLMD 157 QHIQLLQKNVRAQLV PLMD 167 RAQLVDMKRLEVDID PLMD 176 LEVDIDIKIRSCRGS PLMD 195 LAREVDLKDYEDQQK PLMD 202 KDYEDQQKQLEQVIA PLMD 210 QLEQVIAKDLLPSRD PLMD 225 RQHLPLIKMKPVPDL PLMD 227 HLPLIKMKPVPDLVP PLMD 238 DLVPGNFKSQLQKVP PLMD 249 QKVPPEWKALTDMPQ PLMD 432 RREYHTEKLVTSKGD PLMD 437 TEKLVTSKGDKELRT PLMD 446 DKELRTGKEKVTSGS PLMD 448 ELRTGKEKVTSGSTT PLMD 463 TTRRSCSKTVTKTVI PLMD 467 SCSKTVTKTVIGPDG PLMD 476 VIGPDGHKEVTKEVV PLMD 527 FDTASTGKTFPGFFS PLMD 558 SGIFTNTKESSSHHP PLMD 575 AEFPSRGKSSSYSKQ PLMD 581 GKSSSYSKQFTSSTS PLMD 599 GDSTFESKSYKMADE PLMD 602 TFESKSYKMADEAGS PLMD 620 HEGTHSTKRGHAKSR PLMD 71 CPSGCRMKGLIDEVN PLMD 89 TNRINKLKNSLFEYQ PLMD 97 NSLFEYQKNNKDSHS PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

F8W1J3	P02671	HPRD; MINT
P00488	P02671	HPRD
P00734	P02671	HPRD
P00750	P02671	HPRD
P01857	P02671	IntAct
P01876	P02671	IntAct
P02647	P02671	IntAct
P02671	P02671	HPRD
P02671	P02675	HPRD; IntAct
P02671	P02679	HPRD; IntAct
P02671	P02768	IntAct
P02671	P04196	HPRD
P02671	P05106	HPRD
P02671	P05154	HPRD
P02671	P05783	IntAct
P02671	P07996	HPRD
P02671	P08514	HPRD
P02671	P08697	HPRD
P02671	P14543	HPRD
P02671	P33151	HPRD
P02671	P48634	IntAct
P02671	Q92876	IntAct
P02671	Q96RG2	MINT
P02671	Q9H081	IntAct

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction