P02549

※ Protein Information

Tag	Content
UniProt Accession	SPTA1_HUMAN; P02549;
Entrez ID	6708
GenBank Protein ID	NM_003126.2; XM_011509916.2;
GenBank Nucleotide ID	NP_003117.2; XP_011508218.1;
Protein Name	Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)
Gene Name	SPTA1; SPTA
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Functional Description Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
Sequence (Fasta)	MEQFPKETVV ESSGPKVLET AEEIQERRQE VLTRYQSFKE RVAERGQKLE DSYHLQVFKR 60 DADDLGKWIM EKVNILTDKS YEDPTNIQGK YQKHQSLEAE VQTKSRLMSE LEKTREERFT 120 MGHSAHEETK AHIEELRHLW DLLLELTLEK GDQLLRALKF QQYVQECADI LEWIGDKEAI 180 ATSVELGEDW ERTEVLHKKF EDFQVELVAK EGRVVEVNQY ANECAEENHP DLPLIQSKQN 240 EVNAAWERLR GLALQRQKAL SNAANLQRFK RDVTEAIQWI KEKEPVLTSE DYGKDLVASE 300 GLFHSHKGLE RNLAVMSDKV KELCAKAEKL TLSHPSDAPQ IQEMKEDLVS SWEHIRALAT 360 SRYEKLQATY WYHRFSSDFD ELSGWMNEKT AAINADELPT DVAGGEVLLD RHQQHKHEID 420 SYDDRFQSAD ETGQDLVNAN HEASDEVREK MEILDNNWTA LLELWDERHR QYEQCLDFHL 480 FYRDSEQVDS WMSRQEAFLE NEDLGNSLGS AEALLQKHED FEEAFTAQEE KIITVDKTAT 540 KLIGDDHYDS ENIKAIRDGL LARRDALREK AATRRRLLKE SLLLQKLYED SDDLKNWINK 600 KKKLADDEDY KDIQNLKSRV QKQQVFEKEL AVNKTQLENI QKTGQEMIEG GHYASDNVTT 660 RLSEVASLWE ELLEATKQKG TQLHEANQQL QFENNAEDLQ RWLEDVEWQV TSEDYGKGLA 720 EVQNRLRKHG LLESAVAARQ DQVDILTDLA AYFEEIGHPD SKDIRARQES LVCRFEALKE 780 PLATRKKKLL DLLHLQLICR DTEDEEAWIQ ETEPSATSTY LGKDLIASKK LLNRHRVILE 840 NIASHEPRIQ EITERGNKMV EEGHFAAEDV ASRVKSLNQN MESLRARAAR RQNDLEANVQ 900 FQQYLADLHE AETWIREKEP IVDNTNYGAD EEAAGALLKK HEAFLLDLNS FGDSMKALRN 960 QANACQQQQA APVEGVAGEQ RVMALYDFQA RSPREVTMKK GDVLTLLSSI NKDWWKVEAA 1020 DHQGIVPAVY VRRLAHDEFP MLPQRRREEP GNITQRQEQI ENQYRSLLDR AEERRRRLLQ 1080 RYNEFLLAYE AGDMLEWIQE KKAENTGVEL DDVWELQKKF DEFQKDLNTN EPRLRDINKV 1140 ADDLLFEGLL TPEGAQIRQE LNSRWGSLQR LADEQRQLLG SAHAVEVFHR EADDTKEQIE 1200 KKCQALSAAD PGSDLFSVQA LQRRHEGFER DLVPLGDKVT ILGETAERLS ESHPDATEDL 1260 QRQKMELNEA WEDLQGRTKD RKESLNEAQK FYLFLSKARD LQNWISSIGG MVSSQELAED 1320 LTGIEILLER HQEHRADMEA EAPTFQALED FSAELIDSGH HASPEIEKKL QAVKLERDDL 1380 EKAWEKRKKI LDQCLELQMF QGNCDQVESW MVARENSLRS DDKSSLDSLE ALMKKRDDLD 1440 KAITAQEGKI TDLEHFAESL IADEHYAKEE IATRLQRVLD RWKALKAQLI DERTKLGDYA 1500 NLKQFYRDLE ELEEWISEML PTACDESYKD ATNIQRKYLK HQTFAHEVDG RSEQVHGVIN 1560 LGNSLIECSA CDGNEEAMKE QLEQLKEHWD HLLERTNDKG KKLNEASRQQ RFNTSIRDFE 1620 FWLSEAETLL AMKDQARDLA SAGNLLKKHQ LLEREMLARE DALKDLNTLA EDLLSSGTFN 1680 VDQIVKKKDN VNKRFLNVQE LAAAHHEKLK EAYALFQFFQ DLDDEESWIE EKLIRVSSQD 1740 YGRDLQGVQN LLKKHKRLEG ELVAHEPAIQ NVLDMAEKLK DKAAVGQEEI QLRLAQFVEH 1800 WEKLKELAKA RGLKLEESLE YLQFMQNAEE EEAWINEKNA LAVRGDCGDT LAATQSLLMK 1860 HEALENDFAV HETRVQNVCA QGEDILNKVL QEESQNKEIS SKIEALNEKT PSLAKAIAAW 1920 KLQLEDDYAF QEFNWKADVV EAWIADKETS LKTNGNGADL GDFLTLLAKQ DTLDASLQSF 1980 QQERLPEITD LKDKLISAQH NQSKAIEERY AALLKRWEQL LEASAVHRQK LLEKQLPLQK 2040 AEDLFVEFAH KASALNNWCE KMEENLSEPV HCVSLNEIRQ LQKDHEDFLA SLARAQADFK 2100 CLLELDQQIK ALGVPSSPYT WLTVEVLERT WKHLSDIIEE REQELQKEEA RQVKNFEMCQ 2160 EFEQNASTFL QWILETRAYF LDGSLLKETG TLESQLEANK RKQKEIQAMK RQLTKIVDLG 2220 DNLEDALILD IKYSTIGLAQ QWDQLYQLGL RMQHNLEQQI QAKDIKGVSE ETLKEFSTIY 2280 KHFDENLTGR LTHKEFRSCL RGLNYYLPMV EEDEHEPKFE KFLDAVDPGR KGYVSLEDYT 2340 AFLIDKESEN IKSSDEIENA FQALAEGKSY ITKEDMKQAL TPEQVSFCAT HMQQYMDPRG 2400 RSHLSGYDYV GFTNSYFGN Fasta Sequence >P02549\|SPTA1; SPTA\|Homo sapiens (Human) MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRGRSHLSGYDYVGFTNSYFGN

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Tyrosine Phosphorylation	Sickle-cell disease	U	Y422	20206558
1	[Reference]: In SCD RBCs we identified the phosphopeptides for protein 4.1R located in the protein FERM domain (Tyr-13) and for alpha-spectrin located near or in a linker region (Tyr-422 and Tyr-1498) involving protein areas crucial for their functions in the context of red cell membrane properties, suggesting that Tyr-phosphorylation may be part of the events involved in maintaining membrane mechanical stability in SCD red cells.
2	Tyrosine Phosphorylation	Sickle-cell disease	U	Y548	20206558
2	[Reference]: Deoxygenation affects tyrosine phosphoproteome of red cell membrane from patients with sickle cell disease.
3	Tyrosine Phosphorylation	Sickle-cell disease	U	Y1499	20206558
3	[Reference]: In SCD RBCs we identified the phosphopeptides for protein 4.1R located in the protein FERM domain (Tyr-13) and for alpha-spectrin located near or in a linker region (Tyr-422 and Tyr-1498) involving protein areas crucial for their functions in the context of red cell membrane properties, suggesting that Tyr-phosphorylation may be part of the events involved in maintaining membrane mechanical stability in SCD red cells.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:C565058 ; Elliptocytosis 2 MESH:C563004 ; Pyropoikilocytosis, Hereditary MESH:C567489 ; Spherocytosis, Type 3
GWASdb (count: 54) (view all)	rs2479868; Other erythrocyte phenotypes; hematopoietic system disease rs2479868; Red blood cell traits; hematopoietic system disease rs12128171; Red blood cell traits; hematopoietic system disease rs12601; Iris characteristics; iris disease rs2157691; Other erythrocyte phenotypes; hematopoietic system disease rs2157691; Red blood cell traits; hematopoietic system disease rs2518491; Other erythrocyte phenotypes; hematopoietic system disease rs2518491; Red blood cell traits; hematopoietic system disease rs2779116; Other erythrocyte phenotypes; hematopoietic system disease rs2779116; Glycated hemoglobin levels; hemoglobinopathy\|diabetes mellitus rs2779116; Red blood cell traits; hematopoietic system disease rs2022003; Red blood cell traits; hematopoietic system disease rs7553252; Red blood cell traits; hematopoietic system disease rs1616; Smoking initiation; nicotine dependence rs12088990; Red blood cell traits; hematopoietic system disease rs3737515; Red blood cell traits; hematopoietic system disease rs4511106; Red blood cell traits; hematopoietic system disease rs12138682; Red blood cell traits; hematopoietic system disease rs6682458; Red blood cell traits; hematopoietic system disease rs11811522; Serum metabolites; Null rs11811522; Red blood cell traits; hematopoietic system disease rs16830483; Alzheimer's disease; Alzheimer's disease rs3738791; Red blood cell traits; hematopoietic system disease rs857725; Other erythrocyte phenotypes; hematopoietic system disease rs857725; Mean corpuscular hemoglobin concentration; hematopoietic system disease rs857725; Red blood cell traits; hematopoietic system disease rs857721; Other erythrocyte phenotypes; hematopoietic system disease rs857721; Blood cell counts and other traits; hematopoietic system disease\|Human immunodeficiency virus infectious disease\|myocardial infarction rs857721; Red blood cell traits; hematopoietic system disease rs6702040; Red blood cell traits; hematopoietic system disease rs10443907; Red blood cell traits; hematopoietic system disease rs17635940; Red blood cell traits; hematopoietic system disease rs12076831; Red blood cell traits; hematopoietic system disease rs10443899; Red blood cell traits; hematopoietic system disease rs2246434; Other erythrocyte phenotypes; hematopoietic system disease rs2246434; Glycated hemoglobin levels; hemoglobinopathy\|diabetes mellitus rs2246434; Red blood cell traits; hematopoietic system disease rs861409; Red blood cell traits; hematopoietic system disease rs863327; Red blood cell traits; hematopoietic system disease rs16840439; Lung function (forced expiratory volume in 1 second); lung disease rs2276401; Lung function (forced expiratory flow between 25% and 75% of forced vital capacity); lung disease rs857691; Red blood cell traits; hematopoietic system disease rs2518493; Red blood cell traits; hematopoietic system disease rs7519423; Multiple complex diseases; Null rs71579625; White blood cell count; hematopoietic system disease\|myocardial infarction rs857680; White blood cell count; hematopoietic system disease\|myocardial infarction rs703115; Sudden cardiac arrest; coronary artery disease rs378557; White blood cell count; hematopoietic system disease\|myocardial infarction rs703116; White blood cell count; hematopoietic system disease\|myocardial infarction rs325998; White blood cell count; hematopoietic system disease\|myocardial infarction rs325993; White blood cell count; hematopoietic system disease\|myocardial infarction rs703124; White blood cell count; hematopoietic system disease\|myocardial infarction rs413514; White blood cell count; hematopoietic system disease\|myocardial infarction rs390718; White blood cell count; hematopoietic system disease\|myocardial infarction

Database

Annotation

CTD (Curated)
(count: 3)

MESH:C565058 ; Elliptocytosis 2
MESH:C563004 ; Pyropoikilocytosis, Hereditary
MESH:C567489 ; Spherocytosis, Type 3

GWASdb
(count: 54)
(view all)

rs2479868; Other erythrocyte phenotypes; hematopoietic system disease
rs2479868; Red blood cell traits; hematopoietic system disease
rs12128171; Red blood cell traits; hematopoietic system disease
rs12601; Iris characteristics; iris disease
rs2157691; Other erythrocyte phenotypes; hematopoietic system disease
rs2157691; Red blood cell traits; hematopoietic system disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 35) (view all)	1064 QEQIENQYRSLLDRA dbPAF 1167 ELNSRWGSLQRLADE dbPAF 1250 GETAERLSESHPDAT dbPAF 1257 SESHPDATEDLQRQK dbPAF 1278 WEDLQGRTKDRKESL dbPAF 1284 RTKDRKESLNEAQKF dbPAF 1363 IDSGHHASPEIEKKL dbPAF 1424 SLRSDDKSSLDSLEA dbPAF 1425 LRSDDKSSLDSLEAL dbPAF 1428 DDKSSLDSLEALMKK dbPAF 1499 ERTKLGDYANLKQFY dbPAF 1538 ATNIQRKYLKHQTFA dbPAF 1901 SQNKEISSKIEALNE dbPAF 1910 IEALNEKTPSLAKAI dbPAF 1912 ALNEKTPSLAKAIAA dbPAF 1976 KQDTLDASLQSFQQE dbPAF 2269 AKDIKGVSEETLKEF dbPAF 2333 VDPGRKGYVSLEDYT dbPAF 2405 PRGRSHLSGYDYVGF dbPAF 2407 GRSHLSGYDYVGFTN dbPAF 299 YGKDLVASEGLFHSH dbPAF 317 ERNLAVMSDKVKELC dbPAF 361 HIRALATSRYEKLQA dbPAF 37 EVLTRYQSFKERVAE dbPAF 370 YEKLQATYWYHRFSS dbPAF 422 HKHEIDSYDDRFQSA dbPAF 507 ENEDLGNSLGSAEAL dbPAF 548 KLIGDDHYDSENIKA dbPAF 588 SLLLQKLYEDSDDLK dbPAF 635 KELAVNKTQLENIQK dbPAF 812 EEAWIQETEPSATST dbPAF 818 ETEPSATSTYLGKDL dbPAF 876 DVASRVKSLNQNMES dbPAF 986 EQRVMALYDFQARSP dbPAF 992 LYDFQARSPREVTMK dbPAF
Acetylation (count: 2)	1803 QFVEHWEKLKELAKA PLMD 283 AIQWIKEKEPVLTSE PLMD
Ubiquitination (count: 1)	1803 QFVEHWEKLKELAKA PLMD
Glycation (count: 58) (view all)	104 LEAEVQTKSRLMSEL PLMD 1102 LEWIQEKKAENTGVE PLMD 1238 DLVPLGDKVTILGET PLMD 1290 ESLNEAQKFYLFLSK PLMD 130 HSAHEETKAHIEELR PLMD 1374 EKKLQAVKLERDDLE PLMD 1468 IADEHYAKEEIATRL PLMD 1486 LDRWKALKAQLIDER PLMD 1503 LGDYANLKQFYRDLE PLMD 1579 DGNEEAMKEQLEQLK PLMD 1586 KEQLEQLKEHWDHLL PLMD 159 DQLLRALKFQQYVQE PLMD 1648 SAGNLLKKHQLLERE PLMD 1708 LAAAHHEKLKEAYAL PLMD 1732 EESWIEEKLIRVSSQ PLMD 1803 QFVEHWEKLKELAKA PLMD 1902 QNKEISSKIEALNEK PLMD 1947 VEAWIADKETSLKTN PLMD 1992 LPEITDLKDKLISAQ PLMD 1994 EITDLKDKLISAQHN PLMD 2040 EKQLPLQKAEDLFVE PLMD 2051 LFVEFAHKASALNNW PLMD 2061 ALNNWCEKMEENLSE PLMD 210 FQVELVAKEGRVVEV PLMD 2132 EVLERTWKHLSDIIE PLMD 2147 EREQELQKEEARQVK PLMD 2200 ESQLEANKRKQKEIQ PLMD 2202 QLEANKRKQKEIQAM PLMD 2263 LEQQIQAKDIKGVSE PLMD 2331 DAVDPGRKGYVSLED PLMD 2352 DKESENIKSSDEIEN PLMD 2373 EGKSYITKEDMKQAL PLMD 238 DLPLIQSKQNEVNAA PLMD 281 TEAIQWIKEKEPVLT PLMD 283 AIQWIKEKEPVLTSE PLMD 319 NLAVMSDKVKELCAK PLMD 326 KVKELCAKAEKLTLS PLMD 345 APQIQEMKEDLVSSW PLMD 389 LSGWMNEKTAAINAD PLMD 416 LDRHQQHKHEIDSYD PLMD 450 ASDEVREKMEILDNN PLMD 48 RVAERGQKLEDSYHL PLMD 541 TVDKTATKLIGDDHY PLMD 554 HYDSENIKAIRDGLL PLMD 579 ATRRRLLKESLLLQK PLMD 586 KESLLLQKLYEDSDD PLMD 59 SYHLQVFKRDADDLG PLMD 595 YEDSDDLKNWINKKK PLMD 634 EKELAVNKTQLENIQ PLMD 642 TQLENIQKTGQEMIE PLMD 67 RDADDLGKWIMEKVN PLMD 72 LGKWIMEKVNILTDK PLMD 728 EVQNRLRKHGLLESA PLMD 779 VCRFEALKEPLATRK PLMD 858 EITERGNKMVEEGHF PLMD 918 AETWIREKEPIVDNT PLMD 93 NIQGKYQKHQSLEAE PLMD 940 AAGALLKKHEAFLLD PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

P02549	P11277	DIP; IntAct
P02549	P22681	IntAct
P02549	P29353	IntAct
P02549	Q06187	IntAct

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction