Tag | Content |
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UniProt Accession | P53_MOUSE; P02340; |
Entrez ID | 22059 |
GenBank Protein ID | NM_001127233.1; NM_011640.3; XM_006533157.3; |
GenBank Nucleotide ID | NP_001120705.1; NP_035770.2; XP_006533220.1; |
Protein Name | Cellular tumor antigen p53 (Tumor suppressor p53) |
Gene Name | Tp53; P53; Trp53 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF i(view all) |
Sequence (Fasta) | MEESQSDISL ELPLSQETFS GLWKLLPPED ILPSPHCMDD LLLPQDVEEF FEGPSEALRV 60 SGAPAAQDPV TETPGPVAPA PATPWPLSSF VPSQKTYQGN YGFHLGFLQS GTAKSVMCTY 120 SPPLNKLFCQ LAKTCPVQLW VSATPPAGSR VRAMAIYKKS QHMTEVVRRC PHHERCSDGD 180 GLAPPQHLIR VEGNLYPEYL EDRQTFRHSV VVPYEPPEAG SEYTTIHYKY MCNSSCMGGM 240 NRRPILTIIT LEDSSGNLLG RDSFEVRVCA CPGRDRRTEE ENFRKKEVLC PELPPGSAKR 300 ALPTCTSASP PQKKKPLDGE YFTLKIRGRK RFEMFRELNE ALELKDAHAT EESGDSRAHS 360 SYLKTKKGQS TSRHKKTMVK KVGPDSD 388 |
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Database | Annotation |
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CTD (Curated) (count: 43) (view all) | MESH:D000230
; Adenocarcinoma MESH:C538231 ; Adenocarcinoma of lung MESH:D001254 ; Astrocytoma MESH:D001848 ; Bone Diseases, Developmental MESH:D001932 ; Brain Neoplasms MESH:D001943 ; Breast Neoplasms |
PTM | Modification Sites |
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Phosphorylation (count: 20) (view all) | 149 SATPPAGSRVRAMAI dbPAF
15 ISLELPLSQETFSGL dbPAF 18 ELPLSQETFSGLWKL dbPAF 20 PLSQETFSGLWKLLP dbPAF 223 PPEAGSEYTTIHYKY dbPAF 228 SEYTTIHYKYMCNSS dbPAF |
Acetylation (count: 11) (view all) | 126 TYSPPLNKLFCQLAK PLMD
299 ELPPGSAKRALPTCT PLMD 314 SASPPQKKKPLDGEY PLMD 315 ASPPQKKKPLDGEYF PLMD 325 DGEYFTLKIRGRKRF PLMD 364 RAHSSYLKTKKGQST PLMD |
Methylation (count: 1) | 366 HSSYLKTKKGQSTSR PLMD |