P01589

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession IL2RA_HUMAN; P01589;
Entrez ID 3559
GenBank Protein ID NM_000417.2; NM_001308242.1; NM_001308243.1;
GenBank Nucleotide ID NP_000408.1; NP_001295171.1; NP_001295172.1;
Protein Name Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25)
Gene Name IL2RA
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionReceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Sequence
(Fasta)
MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE CKRGFRRIKS 60
GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE QKERKTTEMQ SPMQPVDQAS 120
LPGHCREPPP WENEATERIY HFVVGQMVYY QCVQGYRALH RGPAESVCKM THGKTRWTQP 180
QLICTGEMET SQFPGEEKPQ ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ 240
VAVAGCVFLL ISVLLLSGLT WQRRQRKSRR TI 273

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationGlioblastomaD9326745
[Reference]: A selective impairment of the IL-2 system in lymphocytes of patients with glioblastomas: increased level of soluble IL-2R and reduced protein tyrosine phosphorylation.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 13)
(view all)
MESH:D000506 ; Alopecia Areata
MESH:D001172 ; Arthritis, Rheumatoid
MESH:D001607 ; Berylliosis
MESH:D003424 ; Crohn Disease
MESH:D017449 ; Dermatitis, Allergic Contact
MESH:C566602 ; Diabetes Mellitus, Insulin-Dependent, 10
DisGeNet (Curated)
(count: 54)
(view all)
C0002170; Alopecia
C0002171; Alopecia Areata
C0002880; Autoimmune hemolytic anemia
C0003635; Apraxias
C0003862; Arthralgia
C0003873; Rheumatoid Arthritis
HGMD
(count: 5)
CD972267; Immunodeficiency; Small deletions
CI073748; CD25 deficiency; Small insertions
CM073075; CD25 deficiency; Missense/nonsense
CR075252; Diabetes, type 1, association with ?; Regulatory
CR075253; Diabetes, type 1, association with ?; Regulatory
GWASdb
(count: 45)
(view all)
rs12722605; Inflammatory biomarkers; Null
rs9663421; Response to statin treatment (atorvastatin), change in cholesterol levels; cardiovascular system disease
rs9663421; Self-reported allergy; hypersensitivity reaction disease
rs2076846; Self-reported allergy; hypersensitivity reaction disease
rs2025345; Serum metabolites; Null
rs2025345; Self-reported allergy; hypersensitivity reaction disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 2)
268       WQRRQRKSRRTI***     dbPAF
271       RQRKSRRTI******     dbPAF
Glycation
(count: 2)
37        EIPHATFKAMAYKEG     PLMD
52        TMLNCECKRGFRRIK     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource