Tag | Content |
---|---|
UniProt Accession | IL2RA_HUMAN; P01589; |
Entrez ID | 3559 |
GenBank Protein ID | NM_000417.2; NM_001308242.1; NM_001308243.1; |
GenBank Nucleotide ID | NP_000408.1; NP_001295171.1; NP_001295172.1; |
Protein Name | Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25) |
Gene Name | IL2RA |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. |
Sequence (Fasta) | MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE CKRGFRRIKS 60 GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE QKERKTTEMQ SPMQPVDQAS 120 LPGHCREPPP WENEATERIY HFVVGQMVYY QCVQGYRALH RGPAESVCKM THGKTRWTQP 180 QLICTGEMET SQFPGEEKPQ ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ 240 VAVAGCVFLL ISVLLLSGLT WQRRQRKSRR TI 273 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 13) (view all) | MESH:D000506
; Alopecia Areata MESH:D001172 ; Arthritis, Rheumatoid MESH:D001607 ; Berylliosis MESH:D003424 ; Crohn Disease MESH:D017449 ; Dermatitis, Allergic Contact MESH:C566602 ; Diabetes Mellitus, Insulin-Dependent, 10 |
DisGeNet (Curated) (count: 54) (view all) | C0002170; Alopecia
C0002171; Alopecia Areata C0002880; Autoimmune hemolytic anemia C0003635; Apraxias C0003862; Arthralgia C0003873; Rheumatoid Arthritis |
HGMD (count: 5) | CD972267; Immunodeficiency; Small deletions
CI073748; CD25 deficiency; Small insertions CM073075; CD25 deficiency; Missense/nonsense CR075252; Diabetes, type 1, association with ?; Regulatory CR075253; Diabetes, type 1, association with ?; Regulatory |
GWASdb (count: 45) (view all) | rs12722605; Inflammatory biomarkers; Null
rs9663421; Response to statin treatment (atorvastatin), change in cholesterol levels; cardiovascular system disease rs9663421; Self-reported allergy; hypersensitivity reaction disease rs2076846; Self-reported allergy; hypersensitivity reaction disease rs2025345; Serum metabolites; Null rs2025345; Self-reported allergy; hypersensitivity reaction disease |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 2) | 268 WQRRQRKSRRTI*** dbPAF
271 RQRKSRRTI****** dbPAF |
Glycation (count: 2) | 37 EIPHATFKAMAYKEG PLMD
52 TMLNCECKRGFRRIK PLMD |
Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|