P01137

※ Protein Information

Tag	Content
UniProt Accession	TGFB1_HUMAN; P01137;
Entrez ID	7040
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP)]
Gene Name	TGFB1; TGFB
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane pro(view all) Functional Description Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292).
Sequence (Fasta)	MPPSGLRLLL LLLPLLWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA 60 SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESAEPEPEPE ADYYAKEVTR VLMVETHNEI 120 YDKFKQSTHS IYMFFNTSEL REAVPEPVLL SRAELRLLRL KLKVEQHVEL YQKYSNNSWR 180 YLSNRLLAPS DSPEWLSFDV TGVVRQWLSR GGEIEGFRLS AHCSCDSRDN TLQVDINGFT 240 TGRRGDLATI HGMNRPFLLL MATPLERAQH LQSSRHRRAL DTNYCFSSTE KNCCVRQLYI 300 DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SAAPCCVPQA 360 LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS 391 Fasta Sequence >P01137\|TGFB1; TGFB\|Homo sapiens (Human) MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Phosphorylation	Small intestinal carcinoid		P		17469181
1	[Reference]: The TGFbetaRII transcript and protein were identified in tumor cells and the effects of TGFbeta1 on SMAD2 phosphorylation and nuclear translocation quantified.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 78) (view all)	MESH:D000022 ; Abortion, Spontaneous MESH:C535662 ; Acromicric dysplasia MESH:D058186 ; Acute Kidney Injury MESH:D055371 ; Acute Lung Injury MESH:D000230 ; Adenocarcinoma MESH:D001022 ; Aortic Valve Insufficiency MESH:D001249 ; Asthma MESH:D059366 ; Asthma, Occupational MESH:D001607 ; Berylliosis MESH:D002114 ; Calcinosis MESH:D003966 ; Camurati-Engelmann Syndrome MESH:D002277 ; Carcinoma MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002294 ; Carcinoma, Squamous Cell MESH:D002296 ; Carcinosarcoma MESH:D002471 ; Cell Transformation, Neoplastic MESH:D001651 ; Cholestasis, Extrahepatic MESH:D002972 ; Cleft Palate MESH:D015179 ; Colorectal Neoplasms MESH:C566858 ; Copper-Overload Cirrhosis MESH:D003550 ; Cystic Fibrosis MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D003924 ; Diabetes Mellitus, Type 2 MESH:D003928 ; Diabetic Nephropathies MESH:D003929 ; Diabetic Neuropathies MESH:D015352 ; Dry Eye Syndromes MESH:D004381 ; Duodenal Ulcer MESH:D004719 ; Endomyocardial Fibrosis MESH:D005355 ; Fibrosis MESH:D005922 ; Glomerulonephritis, IGA MESH:D005923 ; Glomerulosclerosis, Focal Segmental MESH:D019693 ; Hepatitis, Autoimmune MESH:D006521 ; Hepatitis, Chronic MESH:D006548 ; Hernia, Diaphragmatic MESH:D006965 ; Hyperplasia MESH:D006967 ; Hypersensitivity MESH:D006973 ; Hypertension MESH:D007249 ; Inflammation MESH:D055959 ; Intervertebral Disc Degeneration MESH:D007674 ; Kidney Diseases MESH:D007676 ; Kidney Failure, Chronic MESH:D008103 ; Liver Cirrhosis MESH:D008104 ; Liver Cirrhosis, Alcoholic MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D008114 ; Liver Neoplasms, Experimental MESH:D008171 ; Lung Diseases MESH:D008175 ; Lung Neoplasms MESH:D009135 ; Muscular Diseases MESH:D020388 ; Muscular Dystrophy, Duchenne MESH:D009203 ; Myocardial Infarction MESH:D009361 ; Neoplasm Invasiveness MESH:D009362 ; Neoplasm Metastasis MESH:D009404 ; Nephrotic Syndrome MESH:D065626 ; Non-alcoholic Fatty Liver Disease MESH:D009784 ; Occupational Diseases MESH:D009914 ; Oral Submucous Fibrosis MESH:D010024 ; Osteoporosis MESH:D015663 ; Osteoporosis, Postmenopausal MESH:D010190 ; Pancreatic Neoplasms MESH:D010212 ; Papilloma MESH:D010411 ; Penile Induration MESH:D056627 ; Peritoneal Fibrosis MESH:D010995 ; Pleural Diseases MESH:D011014 ; Pneumonia MESH:D011471 ; Prostatic Neoplasms MESH:D011507 ; Proteinuria MESH:D029424 ; Pulmonary Disease, Chronic Obstructive MESH:D011656 ; Pulmonary Emphysema MESH:D011658 ; Pulmonary Fibrosis MESH:D012507 ; Sarcoidosis MESH:D018805 ; Sepsis MESH:D012878 ; Skin Neoplasms MESH:D020521 ; Stroke MESH:D013920 ; Thrombocythemia, Essential MESH:D014511 ; Uremia MESH:D014517 ; Ureteral Obstruction MESH:D014581 ; Urticaria MESH:D020257 ; Ventricular Remodeling
GWASdb (count: 5)	rs4803455; Asperger disorder; Asperger syndrome rs4803455; Migraine without aura; migraine without aura rs4803455; Migraine; migraine rs2241716; Colorectal cancer; colorectal cancer rs2241715; Asthma; asthma

Database

Annotation

CTD (Curated)
(count: 78)
(view all)

MESH:D000022 ; Abortion, Spontaneous
MESH:C535662 ; Acromicric dysplasia
MESH:D058186 ; Acute Kidney Injury
MESH:D055371 ; Acute Lung Injury
MESH:D000230 ; Adenocarcinoma
MESH:D001022 ; Aortic Valve Insufficiency

GWASdb
(count: 5)

rs4803455; Asperger disorder; Asperger syndrome
rs4803455; Migraine without aura; migraine without aura
rs4803455; Migraine; migraine
rs2241716; Colorectal cancer; colorectal cancer
rs2241715; Asthma; asthma

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 1)	317 WIHEPKGYHANFCLG dbPAF
Ubiquitination (count: 6)	106 PEADYYAKEVTRVLM PLMD 123 THNEIYDKFKQSTHS PLMD 163 RLLRLKLKVEQHVEL PLMD 291 YCFSSTEKNCCVRQL PLMD 42 TIDMELVKRKRIEAI PLMD 56 IRGQILSKLRLASPP PLMD
Sumoylation (count: 1)	42 TIDMELVKRKRIEAI PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

P01137	P02768	BioGRID
P01137	P05067	IntAct
P01137	P05771	BioGRID
P01137	P09211	BioGRID

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction