Tag | Content |
---|---|
UniProt Accession | RASK_HUMAN; P01116; |
Entrez ID | 3845 |
GenBank Protein ID | NM_004985.4; NM_033360.3; XM_006719069.3; XM_011520653.2; |
GenBank Nucleotide ID | NP_004976.2; NP_203524.1; XP_006719132.1; XP_011518955.1; |
Protein Name | GTPase KRas (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] |
Gene Name | KRAS; KRAS2; RASK2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). |
Sequence (Fasta) | MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 60 QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL 120 PSRTVDTKQA QDLARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC 180 VKIKKCIIM |
|
Database | Annotation |
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Cancer Gene Census | pancreatic, colorectal, lung, thyroid, AML, other tumour types |
CTD (Curated) (count: 52) (view all) | MESH:D000230
; Adenocarcinoma MESH:D018263 ; Adenocarcinoma, Follicular MESH:C538231 ; Adenocarcinoma of lung MESH:D000236 ; Adenoma MESH:D000740 ; Anemia MESH:D001171 ; Arthritis, Juvenile |
DisGeNet (Curated) (count: 308) (view all) | C0000737; Abdominal Pain
C0001418; Adenocarcinoma C0001430; Adenoma C0002170; Alopecia C0003467; Anxiety C0003492; Aortic coarctation |
HGMD (count: 19) (view all) | CM070963; Costello syndrome; Missense/nonsense
CM073168; Costello syndrome; Missense/nonsense CM087372; Multiple mole melanoma syndrome; Missense/nonsense CM076251; Cardio-facio-cutaneous syndrome; Missense/nonsense CM061082; Noonan syndrome; Missense/nonsense CM070964; Cardio-facio-cutaneous syndrome; Missense/nonsense |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 6) | 106 QIKRVKDSEDVPMVL dbPAF
137 AQDLARSYGIPFIET dbPAF 172 QYRLKKISKEEKTPG dbPAF 2 ******MTEYKLVVV dbPAF 4 ****MTEYKLVVVGA dbPAF 64 DTAGQEEYSAMRDQY dbPAF |
Acetylation (count: 1) | 104 REQIKRVKDSEDVPM PLMD |
Ubiquitination (count: 3) | 117 PMVLVGNKCDLPSRT PLMD
128 PSRTVDTKQAQDLAR PLMD 147 PFIETSAKTRQRVED PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |