P01116

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession RASK_HUMAN; P01116;
Entrez ID 3845
GenBank Protein ID NM_004985.4; NM_033360.3; XM_006719069.3; XM_011520653.2;
GenBank Nucleotide ID NP_004976.2; NP_203524.1; XP_006719132.1; XP_011518955.1;
Protein Name GTPase KRas (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene Name KRAS; KRAS2; RASK2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionRas proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).
Sequence
(Fasta)
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 60
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL 120
PSRTVDTKQA QDLARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC 180
VKIKKCIIM

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationPancreatic cancer/carcinoma/adenocarcinomaPS18124371225
[Reference]: Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
pancreatic, colorectal, lung, thyroid, AML, other tumour types
CTD (Curated)
(count: 52)
(view all)
MESH:D000230 ; Adenocarcinoma
MESH:D018263 ; Adenocarcinoma, Follicular
MESH:C538231 ; Adenocarcinoma of lung
MESH:D000236 ; Adenoma
MESH:D000740 ; Anemia
MESH:D001171 ; Arthritis, Juvenile
DisGeNet (Curated)
(count: 308)
(view all)
C0000737; Abdominal Pain
C0001418; Adenocarcinoma
C0001430; Adenoma
C0002170; Alopecia
C0003467; Anxiety
C0003492; Aortic coarctation
HGMD
(count: 19)
(view all)
CM070963; Costello syndrome; Missense/nonsense
CM073168; Costello syndrome; Missense/nonsense
CM087372; Multiple mole melanoma syndrome; Missense/nonsense
CM076251; Cardio-facio-cutaneous syndrome; Missense/nonsense
CM061082; Noonan syndrome; Missense/nonsense
CM070964; Cardio-facio-cutaneous syndrome; Missense/nonsense

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 6)
106       QIKRVKDSEDVPMVL     dbPAF
137       AQDLARSYGIPFIET     dbPAF
172       QYRLKKISKEEKTPG     dbPAF
2         ******MTEYKLVVV     dbPAF
4         ****MTEYKLVVVGA     dbPAF
64        DTAGQEEYSAMRDQY     dbPAF
Acetylation
(count: 1)
104       REQIKRVKDSEDVPM     PLMD
Ubiquitination
(count: 3)
117       PMVLVGNKCDLPSRT     PLMD
128       PSRTVDTKQAQDLAR     PLMD
147       PFIETSAKTRQRVED     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource