P00505

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	AATM_HUMAN; P00505;
Entrez ID	2806
GenBank Protein ID	NM_001286220.1; NM_002080.3;
GenBank Nucleotide ID	NP_001273149.1; NP_002071.2;
Protein Name	Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transamin
Gene Name	GOT2
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Functional Description Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Sequence (Fasta)	MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA FKRDTNSKKM 60 NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG GLAEFCKASA ELALGENSEV 120 LKSGRFVTVQ TISGTGALRI GASFLQRFFK FSRDVFLPKP TWGNHTPIFR DAGMQLQGYR 180 YYDPKTCGFD FTGAVEDISK IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA 240 FFDMAYQGFA SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE 300 AKRVESQLKI LIRPMYSNPP LNGARIAAAI LNTPDLRKQW LQEVKVMADR IIGMRTQLVS 360 NLKKEGSTHN WQHITDQIGM FCFTGLKPEQ VERLIKEFSI YMTKDGRISV AGVTSSNVGY 420 LAHAIHQVTK 431 Fasta Sequence >P00505\|GOT2\|Homo sapiens (Human) MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEVLKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADEAKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKVMADRIIGMRTQLVSNLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGYLAHAIHQVTK

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Acetylation	Pancreatic cancer/carcinoma/adenocarcinoma		U	K159	25755250
1	[Reference]: Finally, we show that GOT2?K159 acetylation is increased in human pancreatic tumors, which correlates with reduced SIRT3 expression. Our study uncovers a previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection.

※ Disease Cross-ref Annotation

Database	Annotation
GWASdb (count: 2)	rs11076256; Suicide attempts in bipolar disorder; bipolar disorder rs12600277; Aortic root size; cardiovascular system disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 22) (view all)	118 ELALGENSEVLKSGR dbPAF 128 LKSGRFVTVQTISGT dbPAF 135 TVQTISGTGALRIGA dbPAF 143 GALRIGASFLQRFFK dbPAF 161 DVFLPKPTWGNHTPI dbPAF 166 KPTWGNHTPIFRDAG dbPAF 199 TGAVEDISKIPEQSV dbPAF 231 EQWKEIATVVKKRNL dbPAF 316 KILIRPMYSNPPLNG dbPAF 317 ILIRPMYSNPPLNGA dbPAF 333 IAAAILNTPDLRKQW dbPAF 360 GMRTQLVSNLKKEGS dbPAF 401 LIKEFSIYMTKDGRI dbPAF 414 RISVAGVTSSNVGYL dbPAF 415 ISVAGVTSSNVGYLA dbPAF 416 SVAGVTSSNVGYLAH dbPAF 420 VTSSNVGYLAHAIHQ dbPAF 429 AHAIHQVTK****** dbPAF 48 PDPILGVTEAFKRDT dbPAF 67 MNLGVGAYRDDNGKP dbPAF 75 RDDNGKPYVLPSVRK dbPAF 96 AKNLDKEYLPIGGLA dbPAF
Acetylation (count: 20) (view all)	107 GGLAEFCKASAELAL PLMD 122 GENSEVLKSGRFVTV PLMD 150 SFLQRFFKFSRDVFL PLMD 159 SRDVFLPKPTWGNHT PLMD 185 GYRYYDPKTCGFDFT PLMD 227 DPRPEQWKEIATVVK PLMD 234 KEIATVVKKRNLFAF PLMD 296 GAFTMVCKDADEAKR PLMD 302 CKDADEAKRVESQLK PLMD 309 KRVESQLKILIRPMY PLMD 338 LNTPDLRKQWLQEVK PLMD 345 KQWLQEVKVMADRII PLMD 363 TQLVSNLKKEGSTHN PLMD 364 QLVSNLKKEGSTHNW PLMD 387 MFCFTGLKPEQVERL PLMD 396 EQVERLIKEFSIYMT PLMD 404 EFSIYMTKDGRISVA PLMD 73 AYRDDNGKPYVLPSV PLMD 90 AEAQIAAKNLDKEYL PLMD 94 IAAKNLDKEYLPIGG PLMD
Ubiquitination (count: 12) (view all)	107 GGLAEFCKASAELAL PLMD 122 GENSEVLKSGRFVTV PLMD 296 GAFTMVCKDADEAKR PLMD 302 CKDADEAKRVESQLK PLMD 338 LNTPDLRKQWLQEVK PLMD 363 TQLVSNLKKEGSTHN PLMD 396 EQVERLIKEFSIYMT PLMD 404 EFSIYMTKDGRISVA PLMD 59 KRDTNSKKMNLGVGA PLMD 73 AYRDDNGKPYVLPSV PLMD 90 AEAQIAAKNLDKEYL PLMD 94 IAAKNLDKEYLPIGG PLMD
Malonylation (count: 12) (view all)	122 GENSEVLKSGRFVTV PLMD 159 SRDVFLPKPTWGNHT PLMD 227 DPRPEQWKEIATVVK PLMD 296 GAFTMVCKDADEAKR PLMD 302 CKDADEAKRVESQLK PLMD 309 KRVESQLKILIRPMY PLMD 338 LNTPDLRKQWLQEVK PLMD 404 EFSIYMTKDGRISVA PLMD 59 KRDTNSKKMNLGVGA PLMD 73 AYRDDNGKPYVLPSV PLMD 82 YVLPSVRKAEAQIAA PLMD 90 AEAQIAAKNLDKEYL PLMD
Succinylation (count: 14) (view all)	122 GENSEVLKSGRFVTV PLMD 159 SRDVFLPKPTWGNHT PLMD 185 GYRYYDPKTCGFDFT PLMD 227 DPRPEQWKEIATVVK PLMD 234 KEIATVVKKRNLFAF PLMD 296 GAFTMVCKDADEAKR PLMD 309 KRVESQLKILIRPMY PLMD 338 LNTPDLRKQWLQEVK PLMD 363 TQLVSNLKKEGSTHN PLMD 404 EFSIYMTKDGRISVA PLMD 59 KRDTNSKKMNLGVGA PLMD 73 AYRDDNGKPYVLPSV PLMD 82 YVLPSVRKAEAQIAA PLMD 90 AEAQIAAKNLDKEYL PLMD