P00338

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	LDHA_HUMAN; P00338;
Entrez ID	3939
GenBank Protein ID	NM_001135239.1; NM_001165414.1; NM_001165415.1; NM_001165416.1; NM_005566.3;
GenBank Nucleotide ID	NP_001128711.1; NP_001158886.1; NP_001158887.1; NP_001158888.1; NP_005557.1;
Protein Name	L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)
Gene Name	LDHA; PIG19
Organism	Homo sapiens
NCBI Taxa ID	9606
Sequence (Fasta)	MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG 60 EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI 120 IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV 180 HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE 240 VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI 300 SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF 333 Fasta Sequence >P00338\|LDHA; PIG19\|Homo sapiens (Human) MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Tyrosine Phosphorylation	Breast cancer/tumor/carcinoma		U	Y10	28218905
1	[Reference]: Our findings demonstrate that LDHA phosphorylation and activation provide pro-invasive, anti-anoikis and pro-metastatic advantages to cancer cells, suggesting that Y10 phosphorylation of LDHA may represent a promising therapeutic target and a prognostic marker for metastatic human cancers.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 4)	MESH:D009202 ; Cardiomyopathies MESH:C538133 ; Lactate dehydrogenase deficiency type A MESH:D009203 ; Myocardial Infarction MESH:D009212 ; Myoglobinuria
DisGeNet (Curated) (count: 23) (view all)	C0005586; Bipolar Disorder C0011570; Mental Depression C0026821; Muscle Cramp C0026837; Muscle Rigidity C0027051; Myocardial Infarction C0027080; Myoglobinuria C0035078; Kidney Failure C0035410; Rhabdomyolysis C0041696; Unipolar Depression C0151576; Elevated creatine kinase C0221170; Muscular stiffness C0231528; Myalgia C0241005; Creatine phosphokinase serum increased C0424551; Impaired exercise tolerance C0525045; Mood Disorders C0878544; Cardiomyopathies C1269683; Major Depressive Disorder C1565489; Renal Insufficiency C1836440; Increased serum lactate C1839604; Renal failure in adulthood C1849488; Increased serum pyruvate C2931743; Lactate dehydrogenase deficiency type A C4020899; Autosomal recessive predisposition
GWASdb (count: 1)	rs2896526; Amyloid A Levels; atherosclerosis\|type 2 diabetes mellitus

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 22) (view all)	10 TLKDQLIYNLLKEEQ dbPAF 127 IIPNVVKYSPNCKLL dbPAF 128 IPNVVKYSPNCKLLI dbPAF 145 NPVDILTYVAWKISG dbPAF 161 PKNRVIGSGCNLDSA dbPAF 167 GSGCNLDSARFRYLM dbPAF 172 LDSARFRYLMGERLG dbPAF 18 NLLKEEQTPQNKITV dbPAF 237 VHKQVVESAYEVIKL dbPAF 239 KQVVESAYEVIKLKG dbPAF 247 EVIKLKGYTSWAIGL dbPAF 248 VIKLKGYTSWAIGLS dbPAF 249 IKLKGYTSWAIGLSV dbPAF 255 TSWAIGLSVADLAES dbPAF 262 SVADLAESIMKNLRR dbPAF 309 DLVKVTLTSEEEARL dbPAF 310 LVKVTLTSEEEARLK dbPAF 319 EEARLKKSADTLWGI dbPAF 322 RLKKSADTLWGIQKE dbPAF 83 KIVSGKDYNVTANSK dbPAF 89 DYNVTANSKLVIITA dbPAF 95 NSKLVIITAGARQQE dbPAF
Acetylation (count: 18) (view all)	118 QRNVNIFKFIIPNVV PLMD 126 FIIPNVVKYSPNCKL PLMD 132 VKYSPNCKLLIVSNP PLMD 14 QLIYNLLKEEQTPQN PLMD 149 ILTYVAWKISGFPKN PLMD 212 NVAGVSLKTLHPDLG PLMD 222 HPDLGTDKDKEQWKE PLMD 224 DLGTDKDKEQWKEVH PLMD 228 DKDKEQWKEVHKQVV PLMD 232 EQWKEVHKQVVESAY PLMD 243 ESAYEVIKLKGYTSW PLMD 278 HPVSTMIKGLYGIKD PLMD 318 EEEARLKKSADTLWG PLMD 328 DTLWGIQKELQF* PLMD 5 *MATLKDQLIYNL PLMD 57 LVDVIEDKLKGEMMD PLMD 59 DVIEDKLKGEMMDLQ PLMD 81 TPKIVSGKDYNVTAN PLMD
Ubiquitination (count: 23) (view all)	118 QRNVNIFKFIIPNVV PLMD 126 FIIPNVVKYSPNCKL PLMD 132 VKYSPNCKLLIVSNP PLMD 14 QLIYNLLKEEQTPQN PLMD 149 ILTYVAWKISGFPKN PLMD 155 WKISGFPKNRVIGSG PLMD 222 HPDLGTDKDKEQWKE PLMD 224 DLGTDKDKEQWKEVH PLMD 228 DKDKEQWKEVHKQVV PLMD 232 EQWKEVHKQVVESAY PLMD 243 ESAYEVIKLKGYTSW PLMD 245 AYEVIKLKGYTSWAI PLMD 278 HPVSTMIKGLYGIKD PLMD 284 IKGLYGIKDDVFLSV PLMD 317 SEEEARLKKSADTLW PLMD 318 EEEARLKKSADTLWG PLMD 328 DTLWGIQKELQF* PLMD 5 *MATLKDQLIYNL PLMD 57 LVDVIEDKLKGEMMD PLMD 59 DVIEDKLKGEMMDLQ PLMD 76 SLFLRTPKIVSGKDY PLMD 81 TPKIVSGKDYNVTAN PLMD 90 YNVTANSKLVIITAG PLMD
Sumoylation (count: 1)	14 QLIYNLLKEEQTPQN PLMD
Glycation (count: 2)	149 ILTYVAWKISGFPKN PLMD 59 DVIEDKLKGEMMDLQ PLMD
Malonylation (count: 6)	126 FIIPNVVKYSPNCKL PLMD 232 EQWKEVHKQVVESAY PLMD 278 HPVSTMIKGLYGIKD PLMD 318 EEEARLKKSADTLWG PLMD 59 DVIEDKLKGEMMDLQ PLMD 81 TPKIVSGKDYNVTAN PLMD
Succinylation (count: 12) (view all)	118 QRNVNIFKFIIPNVV PLMD 126 FIIPNVVKYSPNCKL PLMD 14 QLIYNLLKEEQTPQN PLMD 222 HPDLGTDKDKEQWKE PLMD 228 DKDKEQWKEVHKQVV PLMD 232 EQWKEVHKQVVESAY PLMD 278 HPVSTMIKGLYGIKD PLMD 284 IKGLYGIKDDVFLSV PLMD 328 DTLWGIQKELQF* PLMD 5 *MATLKDQLIYNL PLMD 76 SLFLRTPKIVSGKDY PLMD 81 TPKIVSGKDYNVTAN PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

O15264	P00338	IntAct
P00338	Q92597	IntAct;HPRD