Tag | Content |
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UniProt Accession | PAK4_HUMAN; O96013; |
Entrez ID | 10298 |
GenBank Protein ID | NM_001014831.2; NM_001014832.1; NM_001014834.2; NM_001014835.1; NM_005884.3; XM_011526316.1; XM_011526317.2; XM_011526318.2; XM_011526319.2; XM_011526320.1; |
GenBank Nucleotide ID | NP_001014831.1; NP_001014832.1; NP_001014834.1; NP_001014835.1; NP_005875.1; XP_011524618.1; XP_011524619.1; XP_011524620.1; XP_011524621.1; XP_011524622.1; |
Protein Name | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) |
Gene Name | PAK4; KIAA1142 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofi(view all) |
Sequence (Fasta) | MFGKRKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP KPLVDPACIT 60 SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL RRDSPPPPAR ARQENGMPEE 120 PATTARGGPG KAGSRGRFAG HSEAGGGSGD RRRAGPEKRP KSSREGSGGP QESSRDKRPL 180 SGPDVGTPQP AGLASGAKLA AGRPFNTYPR ADTDHPSRGA QGEPHDVAPN GPSAGGLAIP 240 QSSSSSSRPP TRARGAPSPG VLGPHASEPQ LAPPACTPAA PAVPGPPGPR SPQREPQRVS 300 HEQFRAALQL VVDPGDPRSY LDNFIKIGEG STGIVCIATV RSSGKLVAVK KMDLRKQQRR 360 ELLFNEVVIM RDYQHENVVE MYNSYLVGDE LWVVMEFLEG GALTDIVTHT RMNEEQIAAV 420 CLAVLQALSV LHAQGVIHRD IKSDSILLTH DGRVKLSDFG FCAQVSKEVP RRKSLVGTPY 480 WMAPELISRL PYGPEVDIWS LGIMVIEMVD GEPPYFNEPP LKAMKMIRDN LPPRLKNLHK 540 VSPSLKGFLD RLLVRDPAQR ATAAELLKHP FLAKAGPPAS IVPLMRQNRT R 592 |
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Database | Annotation |
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GWASdb (count: 2) | rs11669124; Amyotrophic lateral sclerosis; amyotrophic lateral sclerosis
rs11669124; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension |
PTM | Modification Sites |
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Phosphorylation (count: 24) (view all) | 104 SNSLRRDSPPPPARA dbPAF
124 MPEEPATTARGGPGK dbPAF 142 RGRFAGHSEAGGGSG dbPAF 148 HSEAGGGSGDRRRAG dbPAF 167 PKSSREGSGGPQESS dbPAF 181 SRDKRPLSGPDVGTP dbPAF |
Ubiquitination (count: 1) | 31 GFDQHEQKFTGLPRQ PLMD |
Methylation (count: 1) | 78 VRGSKGAKDGALTLL PLMD |
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