| Tag | Content |
|---|---|
| UniProt Accession | BCL10_HUMAN; O95999; |
| Entrez ID | 8915 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cell |
| Gene Name | BCL10; CIPER; CLAP |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). |
| Sequence (Fasta) | MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS 60 SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS 120 SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS TVMYHPEGES STTPFFSTNS SLNLPVLEVG 180 RTENTIFSST TLPRPGDPGA PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ 234 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | MALT |
| CTD (Curated) (count: 6) | OMIM:616098
; IMMUNODEFICIENCY 37 MESH:D018442 ; Lymphoma, B-Cell, Marginal Zone MESH:D008224 ; Lymphoma, Follicular MESH:C562839 ; Mesothelioma, Malignant MESH:D008228 ; Lymphoma, Non-Hodgkin MESH:C563236 ; Testicular Germ Cell Tumor |
| HGMD (count: 2) | CM062459; Advanced germ cell tumors, association with; Missense/nonsense
CM062460; Advanced germ cell tumors, association with ?; Missense/nonsense |
| GWASdb (count: 10) (view all) | rs2735590; Serum dimethylarginine levels (symmetric); heart conduction disease|myocardial infarction
rs1060846; Serum dimethylarginine levels (symmetric); heart conduction disease|myocardial infarction rs962409; Serum dimethylarginine levels (symmetric); heart conduction disease|myocardial infarction rs2252408; Serum dimethylarginine levels (asymmetric); heart conduction disease|myocardial infarction rs12134420; Serum dimethylarginine levels (symmetric); heart conduction disease|myocardial infarction rs144541104; Serum dimethylarginine levels (asymmetric/symetric ratio); heart conduction disease|myocardial infarction |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 18) (view all) | 100 NFLIQKITDEVLKLR dbPAF
130 EPFPDGATNNLSRSN dbPAF 134 DGATNNLSRSNSDES dbPAF 136 ATNNLSRSNSDESNF dbPAF 138 NNLSRSNSDESNFSE dbPAF 141 SRSNSDESNFSEKLR dbPAF |
| Acetylation (count: 1) | 67 SSRKRAGKLLDYLQE PLMD |
| Ubiquitination (count: 2) | 118 LEHLKGLKCSSCEPF PLMD
146 DESNFSEKLRASTVM PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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