| Tag | Content |
|---|---|
| UniProt Accession | SNAI1_HUMAN; O95863; |
| Entrez ID | 6615 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) |
| Gene Name | SNAI1; SNAH |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. |
| Sequence (Fasta) | MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL NPTASLPMLI 60 WDSVLAPQAQ PIAWASLRLQ ESPRVAELTS LSDEDSGKGS QPPSPPSPAP SSFSSTSVSS 120 LEAEAYAAFP GLGQVPKQLA QLSEAKDLQA RKAFNCKYCN KEYLSLGALK MHIRSHTLPC 180 VCGTCGKAFS RPWLLQGHVR THTGEKPFSC PHCSRAFADR SNLRAHLQTH SDVKKYQCQA 240 CARTFSRMSL LHKHQESGCS GCPR 265 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 7) (view all) | MESH:C531617
; Amyotrophic lateral sclerosis 1 MESH:D001943 ; Breast Neoplasms MESH:D002471 ; Cell Transformation, Neoplastic MESH:D002779 ; Cholestasis MESH:D009361 ; Neoplasm Invasiveness MESH:D009362 ; Neoplasm Metastasis |
| GWASdb (count: 1) | rs6091080; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 15) (view all) | 100 DEDSGKGSQPPSPPS dbPAF
104 GKGSQPPSPPSPAPS dbPAF 107 SQPPSPPSPAPSSFS dbPAF 11 SFLVRKPSDPNRKPN dbPAF 111 SPPSPAPSSFSSTSV dbPAF 112 PPSPAPSSFSSTSVS dbPAF |
| Ubiquitination (count: 3) | 137 PGLGQVPKQLAQLSE PLMD
146 LAQLSEAKDLQARKA PLMD 98 LSDEDSGKGSQPPSP PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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