Tag | Content |
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UniProt Accession | BAG3_HUMAN; O95817; |
Entrez ID | 9531 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) |
Gene Name | BAG3; BIS |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). |
Sequence (Fasta) | MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN DPRVPSEGPK 60 ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH EGAENRQVHP FHVYPQPGMQ 120 RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ CGQVAAAAAA QPPASHGPER SQSPAASDCS 180 SSSSSASLPS SGRSSLGSHQ LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY 240 QTHQPVYHKI QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD 300 RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP VSQKPPPPSE 360 KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST APAEATPPKP GEAEAPPKHP 420 GVLKVEAILE KVQGLEQAVD NFEGKKTDKK YLMIEEYLTK ELLALDSVDP EGRADVRQAR 480 RDGVRKVQTI LEKLEQKAID VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG 540 NAEDPHTETQ QPEATAAATS NPSSMTDTPG NPAAP 576 |
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Database | Annotation |
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CTD (Curated) (count: 3) | OMIM:613881
; CARDIOMYOPATHY, DILATED, 1HH MESH:D015658 ; HIV Infections MESH:C580316 ; Myofibrillar Myopathy |
HGMD (count: 1) | CM090724; Myofibrillar myopathy; Missense/nonsense
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GWASdb (count: 6) | rs196335; Lung function (forced expiratory volume in 1 second); lung disease
rs196335; Alcohol dependence; alcohol dependence rs196342; Atopy; hypersensitivity reaction disease rs2234962; Dilated cardiomyopathy; dilated cardiomyopathy rs2234962; Response to taxane treatment (placlitaxel); lung cancer rs2234962; Stroke; cerebrovascular disease |
PTM | Modification Sites |
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Phosphorylation (count: 57) (view all) | 114 QVHPFHVYPQPGMQR dbPAF
134 AAAAPQRSQSPLRGM dbPAF 136 AAPQRSQSPLRGMPE dbPAF 171 ASHGPERSQSPAASD dbPAF 173 HGPERSQSPAASDCS dbPAF 177 RSQSPAASDCSSSSS dbPAF |
Acetylation (count: 2) | 349 IRKEVDSKPVSQKPP PLMD
354 DSKPVSQKPPPPSEK PLMD |
Ubiquitination (count: 6) | 149 PETTQPDKQCGQVAA PLMD
249 THQPVYHKIQGDDWE PLMD 365 PSEKVEVKVPPAPVP PLMD 388 SAVPSSPKSVATEER PLMD 450 EGKKTDKKYLMIEEY PLMD 60 RVPSEGPKETPSSAN PLMD |
Sumoylation (count: 1) | 445 AVDNFEGKKTDKKYL PLMD |
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