O95817

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession BAG3_HUMAN; O95817;
Entrez ID 9531
GenBank Protein ID
GenBank Nucleotide ID
Protein Name BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
Gene Name BAG3; BIS
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCo-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
Sequence
(Fasta)
MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN DPRVPSEGPK 60
ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH EGAENRQVHP FHVYPQPGMQ 120
RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ CGQVAAAAAA QPPASHGPER SQSPAASDCS 180
SSSSSASLPS SGRSSLGSHQ LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY 240
QTHQPVYHKI QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD 300
RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP VSQKPPPPSE 360
KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST APAEATPPKP GEAEAPPKHP 420
GVLKVEAILE KVQGLEQAVD NFEGKKTDKK YLMIEEYLTK ELLALDSVDP EGRADVRQAR 480
RDGVRKVQTI LEKLEQKAID VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG 540
NAEDPHTETQ QPEATAAATS NPSSMTDTPG NPAAP 576

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationThyroid cancer/carcinomaPS18723108398
[Reference]: PKC-mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)
OMIM:613881 ; CARDIOMYOPATHY, DILATED, 1HH
MESH:D015658 ; HIV Infections
MESH:C580316 ; Myofibrillar Myopathy
HGMD
(count: 1)
CM090724; Myofibrillar myopathy; Missense/nonsense
GWASdb
(count: 6)
rs196335; Lung function (forced expiratory volume in 1 second); lung disease
rs196335; Alcohol dependence; alcohol dependence
rs196342; Atopy; hypersensitivity reaction disease
rs2234962; Dilated cardiomyopathy; dilated cardiomyopathy
rs2234962; Response to taxane treatment (placlitaxel); lung cancer
rs2234962; Stroke; cerebrovascular disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 57)
(view all)
114       QVHPFHVYPQPGMQR     dbPAF
134       AAAAPQRSQSPLRGM     dbPAF
136       AAPQRSQSPLRGMPE     dbPAF
171       ASHGPERSQSPAASD     dbPAF
173       HGPERSQSPAASDCS     dbPAF
177       RSQSPAASDCSSSSS     dbPAF
Acetylation
(count: 2)
349       IRKEVDSKPVSQKPP     PLMD
354       DSKPVSQKPPPPSEK     PLMD
Ubiquitination
(count: 6)
149       PETTQPDKQCGQVAA     PLMD
249       THQPVYHKIQGDDWE     PLMD
365       PSEKVEVKVPPAPVP     PLMD
388       SAVPSSPKSVATEER     PLMD
450       EGKKTDKKYLMIEEY     PLMD
60        RVPSEGPKETPSSAN     PLMD
Sumoylation
(count: 1)
445       AVDNFEGKKTDKKYL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource