O95816

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession BAG2_HUMAN; O95816;
Entrez ID 9532
GenBank Protein ID NM_004282.3; XM_005249490.3; XM_011514998.2; XM_011514999.2;
GenBank Nucleotide ID NP_004273.1; XP_005249547.1; XP_011513300.1; XP_011513301.1;
Protein Name BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)
Gene Name BAG2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCo-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).
Sequence
(Fasta)		MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE QEKEILLEMI 60
HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET IRNPQQQESL KHATRIIDEV 120
VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN 180
IENSDKAIKL LEHSKGAGSK TLQQNAESRF N 212

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationParkinson's diseaseC24383081
[Reference]: we found that BAG2 also binds with the pathogenic R492X PINK1 mutation directly and more tightly. Moreover, BAG2 stabilises the R492X PINK1 mutation by decreasing its ubiquitination to a greater extent than the wild-type species


※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 15)
(view all)		 133       DDLGNAKSHLMSLYS     dbPAF
137       NAKSHLMSLYSACSS     dbPAF
139       KSHLMSLYSACSSEV     dbPAF
140       SHLMSLYSACSSEVP     dbPAF
143       MSLYSACSSEVPHGP     dbPAF
144       SLYSACSSEVPHGPV     dbPAF
Acetylation
(count: 10)
(view all)		 111       PQQQESLKHATRIID     PLMD
123       IIDEVVNKFLDDLGN     PLMD
132       LDDLGNAKSHLMSLY     PLMD
168       GCALEDQKKIKRRLE     PLMD
186       RNIENSDKAIKLLEH     PLMD
189       ENSDKAIKLLEHSKG     PLMD
Ubiquitination
(count: 12)
(view all)		 111       PQQQESLKHATRIID     PLMD
123       IIDEVVNKFLDDLGN     PLMD
154       PHGPVDQKFQSIVIG     PLMD
168       GCALEDQKKIKRRLE     PLMD
169       CALEDQKKIKRRLET     PLMD
186       RNIENSDKAIKLLEH     PLMD
Succinylation
(count: 1)		 9         AQAKINAKANEGRFC     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource