O95297

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MPZL1_HUMAN; O95297;
Entrez ID 9019
GenBank Protein ID NM_001146191.1; NM_003953.5; NM_024569.4;
GenBank Nucleotide ID NP_001139663.1; NP_003944.1; NP_078845.3;
Protein Name Myelin protein zero-like protein 1 (Protein zero-related)
Gene Name MPZL1; PZR; UNQ849/PRO1787
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
Sequence
(Fasta)		MAASAGAGAV IAAPDSRRWL WSVLAAALGL LTAGVSALEV YTPKEIFVAN GTQGKLTCKF 60
KSTSTTGGLT SVSWSFQPEG ADTTVSFFHY SQGQVYLGNY PPFKDRISWA GDLDKKDASI 120
NIENMQFIHN GTYICDVKNP PDIVVQPGHI RLYVVEKENL PVFPVWVVVG IVTAVVLGLT 180
LLISMILAVL YRRKNSKRDY TGCSTSESLS PVKQAPRKSP SDTEGLVKSL PSGSHQGPVI 240
YAQLDHSGGH HSDKINKSES VVYADIRKN

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationNeuroblastomaUY26324349301
[Reference]: Increased in NB10 cells (MYCN amplified neuroblastoma line) compared to NPC cells (normal neural crest line)

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)		MESH:D002277 ; Carcinoma
MESH:D015674 ; Mammary Neoplasms, Animal
MESH:D008325 ; Mammary Neoplasms, Experimental
GWASdb
(count: 6)		rs16859491; Type 2 diabetes; type 2 diabetes mellitus
rs16859491; Urinary metabolites; kidney disease
rs4145462; Alzheimer's disease (late onset); Alzheimer's disease
rs12757250; Amyotrophic Lateral Sclerosis; amyotrophic lateral sclerosis
rs4472738; Left ventricular hypertrophy; hypertrophic cardiomyopathy
rs3752606; Myopia (pathological); myopia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 21)
(view all)		 16        AVIAAPDSRRWLWSV     dbPAF
200       RKNSKRDYTGCSTSE     dbPAF
204       KRDYTGCSTSESLSP     dbPAF
205       RDYTGCSTSESLSPV     dbPAF
206       DYTGCSTSESLSPVK     dbPAF
208       TGCSTSESLSPVKQA     dbPAF
Ubiquitination
(count: 8)
(view all)		 115       SWAGDLDKKDASINI     PLMD
116       WAGDLDKKDASINIE     PLMD
138       GTYICDVKNPPDIVV     PLMD
213       SESLSPVKQAPRKSP     PLMD
218       PVKQAPRKSPSDTEG     PLMD
228       SDTEGLVKSLPSGSH     PLMD
Sumoylation
(count: 1)		 213       SESLSPVKQAPRKSP     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource