| Tag | Content |
|---|---|
| UniProt Accession | KAT7_HUMAN; O95251; |
| Entrez ID | 11143 |
| GenBank Protein ID | NM_001199155.1; NM_001199156.1; NM_001199157.1; NM_001199158.1; NM_007067.4; |
| GenBank Nucleotide ID | NP_001186084.1; NP_001186085.1; NP_001186086.1; NP_001186087.1; NP_008998.1; |
| Protein Name | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) |
| Gene Name | KAT7; HBO1; HBOa; MYST2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription. |
| Sequence (Fasta) | MPRRKRNAGS SSDGTEDSDF STDLEHTDSS ESDGTSRRSA RVTRSSARLS QSSQDSSPVR 60 NLQSFGTEEP AYSTRRVTRS QQQPTPVTPK KYPLRQTRSS GSETEQVVDF SDRETKNTAD 120 HDESPPRTPT GNAPSSESDI DISSPNVSHD ESIAKDMSLK DSGSDLSHRP KRRRFHESYN 180 FNMKCPTPGC NSLGHLTGKH ERHFSISGCP LYHNLSADEC KVRAQSRDKQ IEERMLSHRQ 240 DDNNRHATRH QAPTERQLRY KEKVAELRKK RNSGLSKEQK EKYMEHRQTY GNTREPLLEN 300 LTSEYDLDLF RRAQARASED LEKLRLQGQI TEGSNMIKTI AFGRYELDTW YHSPYPEEYA 360 RLGRLYMCEF CLKYMKSQTI LRRHMAKCVW KHPPGDEIYR KGSISVFEVD GKKNKIYCQN 420 LCLLAKLFLD HKTLYYDVEP FLFYVMTEAD NTGCHLIGYF SKEKNSFLNY NVSCILTMPQ 480 YMRQGYGKML IDFSYLLSKV EEKVGSPERP LSDLGLISYR SYWKEVLLRY LHNFQGKEIS 540 IKEISQETAV NPVDIVSTLQ ALQMLKYWKG KHLVLKRQDL IDEWIAKEAK RSNSNKTMDP 600 SCLKWTPPKG T 612 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | CCRCC |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 57) (view all) | 10 RRKRNAGSSSDGTED dbPAF
100 PLRQTRSSGSETEQV dbPAF 102 RQTRSSGSETEQVVD dbPAF 104 TRSSGSETEQVVDFS dbPAF 111 TEQVVDFSDRETKNT dbPAF 115 VDFSDRETKNTADHD dbPAF |
| Acetylation (count: 13) (view all) | 155 SHDESIAKDMSLKDS PLMD
160 IAKDMSLKDSGSDLS PLMD 171 SDLSHRPKRRRFHES PLMD 199 SLGHLTGKHERHFSI PLMD 221 NLSADECKVRAQSRD PLMD 229 VRAQSRDKQIEERML PLMD |
| Ubiquitination (count: 6) | 280 SGLSKEQKEKYMEHR PLMD
338 TEGSNMIKTIAFGRY PLMD 376 EFCLKYMKSQTILRR PLMD 524 ISYRSYWKEVLLRYL PLMD 537 YLHNFQGKEISIKEI PLMD 609 CLKWTPPKGT***** PLMD |
| Sumoylation (count: 2) | 184 ESYNFNMKCPTPGCN PLMD
323 RASEDLEKLRLQGQI PLMD |
| Methylation (count: 1) | 376 EFCLKYMKSQTILRR PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |