O75865

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession TPC6A_HUMAN; O75865;
Entrez ID 79090
GenBank Protein ID NM_001270891.1; NM_001270892.1; NM_001270893.1; NM_024108.2;
GenBank Nucleotide ID NP_001257820.1; NP_001257821.1; NP_001257822.1; NP_077013.1;
Protein Name Trafficking protein particle complex subunit 6A (TRAPP complex subunit 6A)
Gene Name TRAPPC6A; HSPC289
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay play a role in vesicular transport during the biogenesis of melanosomes.
Sequence
(Fasta)		MADTVLFEFL HTEMVAELWA HDPDPGPGGQ KMSLSVLEGM GFRVGQALGE RLPRETLAFR 60
EELDVLKFLC KDLWVAVFQK QMDSLRTNHQ GTYVLQDNSF PLLLPMASGL QYLEEAPKFL 120
AFTCGLLRGA LYTLGIESVV TASVAALPVC KFQVVIPKS

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationAlzheimer's diseaseUS3525650666
[Reference]: Together, when WWOX is downregulated, TPC6A? is phosphorylated at Ser35 and becomes aggregated for causing caspase activation that leads to Tau aggregation and A? formation.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)		rs7253652; Urinary metabolites; kidney disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 3)		 112       PMASGLQYLEEAPKF     dbPAF
33        GPGGQKMSLSVLEGM     dbPAF
35        GGQKMSLSVLEGMGF     dbPAF
Ubiquitination
(count: 2)		 158       KFQVVIPKS******     PLMD
80        LWVAVFQKQMDSLRT     PLMD