| Tag | Content |
|---|---|
| UniProt Accession | BCAR3_HUMAN; O75815; |
| Entrez ID | 8412 |
| GenBank Protein ID | NM_001261408.1; NM_001261409.1; NM_001261410.1; NM_001308251.1; NM_003567.3; XM_017002480.1; |
| GenBank Nucleotide ID | NP_001248337.1; NP_001248338.1; NP_001248339.1; NP_001295180.1; NP_003558.1; XP_016857969.1; |
| Protein Name | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) |
| Gene Name | BCAR3; NSP2; SH2D3B; UNQ271/PRO308 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. |
| Sequence (Fasta) | MAAGKFASLP RNMPVNHQFP LASSMDLLSS RSPLAEHRPD AYQDVSIHGT LPRKKKGPPP 60 IRSCDDFSHM GTLPHSKSPR QNSPVTQDGI QESPWQDRHG ETFTFRDPHL LDPTVEYVKF 120 SKERHIMDRT PEKLKKELEE ELLLSSEDLR SHAWYHGRIP RQVSENLVQR DGDFLVRDSL 180 SSPGNFVLTC QWKNLAQHFK INRTVLRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP 240 ISQQSGAIIF QPINRTVPLR CLEEHYGTSP GQAREGSLTK GRPDVAKRLS LTMGGVQARE 300 QNLPRGNLLR NKEKSGSQPA CLDHMQDRRA LSLKAHQSES YLPIGCKLPP QSSGVDTSPC 360 PNSPVFRTGS EPALSPAVVR RVSSDARAGE ALRGSDSQLC PKPPPKPCKV PFLKVPSSPS 420 AWLNSEANYC ELNPAFATGC GRGAKLPSCA QGSHTELLTA KQNEAPGPRN SGVNYLILDD 480 DDRERPWEPA AAQMEKGQWD KGEFVTPLLE TVSSFRPNEF ESKFLPPENK PLETAMLKRA 540 KELFTNNDPK VIAQHVLSMD CRVARILGVS EEMRRNMGVS SGLELITLPH GHQLRLDIIE 600 RHNTMAIGIA VDILGCTGTL EDRAATLSKI IQVAVELKDS MGDLYSFSAL MKALEMPQIT 660 RLEKTWTALR HQYTQTAILY EKQLKPFSKL LHEGRESTCV PPNNVSVPLL MPLVTLMERQ 720 AVTFEGTDMW EKNDQSCEIM LNHLATARFM AEAADSYRMN AERILAGFQP DEEMNEICKT 780 EFQMRLLWGS KGAQVNQTER YEKFNQILTA LSRKLEPPPV KQAEL 826 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D001943
; Breast Neoplasms MESH:D019966 ; Substance-Related Disorders |
| GWASdb (count: 14) (view all) | rs2295330; Coronary heart disease; coronary artery disease
rs6667494; Sarcoidosis; sarcoidosis rs17110111; Insulin resistance; type 2 diabetes mellitus rs236316; Intelligence; attention deficit hyperactivity disorder|cognitive disorder rs3950119; Intelligence; attention deficit hyperactivity disorder|cognitive disorder rs236322; Intelligence; attention deficit hyperactivity disorder|cognitive disorder |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 44) (view all) | 104 DRHGETFTFRDPHLL dbPAF
114 DPHLLDPTVEYVKFS dbPAF 117 LLDPTVEYVKFSKER dbPAF 130 ERHIMDRTPEKLKKE dbPAF 179 GDFLVRDSLSSPGNF dbPAF 181 FLVRDSLSSPGNFVL dbPAF |
| Acetylation (count: 1) | 541 TAMLKRAKELFTNND PLMD |
| Glycation (count: 1) | 682 QTAILYEKQLKPFSK PLMD |
| Malonylation (count: 1) | 541 TAMLKRAKELFTNND PLMD |
| Methylation (count: 1) | 334 DRRALSLKAHQSESY PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |