| Tag | Content |
|---|---|
| UniProt Accession | NCOR1_HUMAN; O75376; |
| Entrez ID | 9611 |
| GenBank Protein ID | NM_001190438.1; NM_001190440.1; NM_006311.3; XM_011524086.2; |
| GenBank Nucleotide ID | NP_001177367.1; NP_001177369.1; NP_006302.2; XP_011522388.1; |
| Protein Name | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) |
| Gene Name | NCOR1; KIAA1047 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. |
| Sequence (Fasta) | MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV SQASQLLQQQ 60 QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD HDSLESKRPR LEQVSDSHFQ 120 RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE 180 LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY 240 DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR 300 KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR KQREQQERFQ 360 RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMFDA EQRRVKFINM 420 NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD KFIQHPKNFG LIASYLERKS VPDCVLYYYL 480 TKKNENYKAL VRRNYGKRRG RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDEEEKDE 540 KEDSKENTKE KDKIDGTAEE TEEREQATPR GRKTANSQGR RKGRITRSMT NEAAAASAAA 600 AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI AKMVGTKSEA 660 QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE SVASTVSAQE DEDIEASNEE 720 ENPEDSEVEA VKPSEDSPEN ATSRGNTEPA VELEPTTETA PSTSPSLAVP STKPAEDESV 780 ETQVNDSISA ETAEQMDVDQ QEHSAEEGSV CDPPPATKAD SVDVEVRVPE NHASKVEGDN 840 TKERDLDRAS EKVEPRDEDL VVAQQINAQR PEPQSDNDSS ATCSADEDVD GEPERQRMFP 900 MDSKPSLLNP TGSILVSSPL KPNPLDLPQL QHRAAVIPPM VSCTPCNIPI GTPVSGYALY 960 QRHIKAMHES ALLEEQRQRQ EQIDLECRSS TSPCGTSKSP NREWEVLQPA PHQVITNLPE 1020 GVRLPTTRPT RPPPPLIPSS KTTVASEKPS FIMGGSISQG TPGTYLTSHN QASYTQETPK 1080 PSVGSISLGL PRQQESAKSA TLPYIKQEEF SPRSQNSQPE GLLVRAQHEG VVRGTAGAIQ 1140 EGSITRGTPT SKISVESIPS LRGSITQGTP ALPQTGIPTE ALVKGSISRM PIEDSSPEKG 1200 REEAASKGHV IYEGKSGHIL SYDNIKNARE GTRSPRTAHE ISLKRSYESV EGNIKQGMSM 1260 RESPVSAPLE GLICRALPRG SPHSDLKERT VLSGSIMQGT PRATTESFED GLKYPKQIKR 1320 ESPPIRAFEG AITKGKPYDG ITTIKEMGRS IHEIPRQDIL TQESRKTPEV VQSTRPIIEG 1380 SISQGTPIKF DNNSGQSAIK HNVKSLITGP SKLSRGMPPL EIVPENIKVV ERGKYEDVKA 1440 GETVRSRHTS VVSSGPSVLR STLHEAPKAQ LSPGIYDDTS ARRTPVSYQN TMSRGSPMMN 1500 RTSDVTISSN KSTNHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH HRGSTAGEVY 1560 RSHLPTHLDP AMPFHRALDP AAAAYLFQRQ LSPTPGYPSQ YQLYAMENTR QTILNDYITS 1620 QQMQVNLRPD VARGLSPREQ PLGLPYPATR GIIDLTNMPP TILVPHPGGT STPPMDRITY 1680 IPGTQITFPP RPYNSASMSP GHPTHLAAAA SAERERERER EKERERERIA AASSDLYLRP 1740 GSEQPGRPGS HGYVRSPSPS VRTQETMLQQ RPSVFQGTNG TSVITPLDPT AQLRIMPLPA 1800 GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE ENLRSRSAAV 1860 SEQQQLEQKT LEVEKRSVQC LYTSSAFPSG KPQPHSSVVY SEAGKDKGPP PKSRYEEELR 1920 TRGKTTITAA NFIDVIITRQ IASDKDARER GSQSSDSSSS LSSHRYETPS DAIEVISPAS 1980 SPAPPQEKLQ TYQPEVVKAN QAENDPTRQY EGPLHHYRPQ QESPSPQQQL PPSSQAEGMG 2040 QVPRTHRLIT LADHICQIIT QDFARNQVSS QTPQQPPTST FQNSPSALVS TPVRTKTSNR 2100 YSPESQAQSV HHQRPGSRVS PENLVDKSRG SRPGKSPERS HVSSEPYEPI SPPQVPVVHE 2160 KQDSLLLLSQ RGAEPAEQRN DARSPGSISY LPSFFTKLEN TSPMVKSKKQ EIFRKLNSSG 2220 GGDSDMAAAQ PGTEIFNLPA VTTSGSVSSR GHSFADPASN LGLEDIIRKA LMGSFDDKVE 2280 DHGVVMSQPM GVVPGTANTS VVTSGETRRE EGDPSPHSGG VCKPKLISKS NSRKSKSPIP 2340 GQGYLGTERP SSVSSVHSEG DYHRQTPGWA WEDRPSSTGS TQFPYNPLTM RMLSSTPPTP 2400 IACAPSAVNQ AAPHQQNRIW EREPAPLLSA QYETLSDSDD 2441 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | breast |
| CTD (Curated) (count: 6) | MESH:D001943
; Breast Neoplasms MESH:D002295 ; Carcinoma, Transitional Cell MESH:D004715 ; Endometriosis MESH:D005909 ; Glioblastoma MESH:D008113 ; Liver Neoplasms MESH:D001749 ; Urinary Bladder Neoplasms |
| GWASdb (count: 15) (view all) | rs7224403; Type 2 diabetes; type 2 diabetes mellitus
rs8067494; Type 2 diabetes; type 2 diabetes mellitus rs8079698; Type 2 diabetes; type 2 diabetes mellitus rs3760296; Type 2 diabetes; type 2 diabetes mellitus rs1073093; Type 2 diabetes; type 2 diabetes mellitus rs1073094; Type 2 diabetes; type 2 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 184) (view all) | 106 VDHDSLESKRPRLEQ dbPAF
1061 GGSISQGTPGTYLTS dbPAF 1111 YIKQEEFSPRSQNSQ dbPAF 1117 FSPRSQNSQPEGLLV dbPAF 1143 AGAIQEGSITRGTPT dbPAF 1145 AIQEGSITRGTPTSK dbPAF |
| Acetylation (count: 15) (view all) | 1048 KTTVASEKPSFIMGG PLMD
1313 ESFEDGLKYPKQIKR PLMD 1334 AFEGAITKGKPYDGI PLMD 1336 EGAITKGKPYDGITT PLMD 1345 YDGITTIKEMGRSIH PLMD 1400 NSGQSAIKHNVKSLI PLMD |
| Ubiquitination (count: 14) (view all) | 1184 IPTEALVKGSISRMP PLMD
1412 SLITGPSKLSRGMPP PLMD 1511 DVTISSNKSTNHERK PLMD 1838 APQMDVSKTKESKHE PLMD 1840 QMDVSKTKESKHEAA PLMD 1869 EQQQLEQKTLEVEKR PLMD |
| Sumoylation (count: 15) (view all) | 1106 SATLPYIKQEEFSPR PLMD
1184 IPTEALVKGSISRMP PLMD 1207 GREEAASKGHVIYEG PLMD 1215 GHVIYEGKSGHILSY PLMD 1226 ILSYDNIKNAREGTR PLMD 1319 LKYPKQIKRESPPIR PLMD |
| Glycation (count: 1) | 1255 ESVEGNIKQGMSMRE PLMD |