| Tag | Content |
|---|---|
| UniProt Accession | TP4A3_HUMAN; O75365; |
| Entrez ID | 11156 |
| GenBank Protein ID | NM_007079.3; NM_032611.2; XM_005250764.2; XM_011516803.1; XM_011516805.1; XM_017012998.1; |
| GenBank Nucleotide ID | NP_009010.2; NP_116000.1; XP_005250821.1; XP_011515105.1; XP_011515107.1; XP_016868487.1; |
| Protein Name | Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) |
| Gene Name | PTP4A3; PRL3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. |
| Sequence (Fasta) | MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK 60 DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI 120 ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM 174 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D003110 ; Colonic Neoplasms |
| DisGeNet (Curated) (count: 1) | C0009375; Colonic Neoplasms |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 1) | 14 PAPVEVSYKHMRFLI dbPAF |
| Acetylation (count: 2) | 155 YLEKYRPKQRLRFKD PLMD
167 FKDPHTHKTRCCVM* PLMD |