Tag | Content |
---|---|
UniProt Accession | BIRC5_MOUSE; O70201; |
Entrez ID | 11799 |
GenBank Protein ID | NM_001012273.1; NM_009689.2; |
GenBank Nucleotide ID | NP_001012273.1; NP_033819.1; |
Protein Name | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) (TIAP) |
Gene Name | Birc5; Api4; Iap4 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. |
Sequence (Fasta) | MGAPALPQIW QLYLKNYRIA TFKNWPFLED CACTPERMAE AGFIHCPTEN EPDLAQCFFC 60 FKELEGWEPD DNPIEEHRKH SPGCAFLTVK KQMEELTVSE FLKLDRQRAK NKIAKETNNK 120 QKEFEETAKT TRQSIEQLAA 141 |
|
Database | Annotation |
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CTD (Curated) (count: 18) (view all) | MESH:D000230
; Adenocarcinoma MESH:D001943 ; Breast Neoplasms MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002292 ; Carcinoma, Renal Cell MESH:D018288 ; Carcinoma, Small Cell MESH:D002294 ; Carcinoma, Squamous Cell |
PTM | Modification Sites |
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Phosphorylation (count: 2) | 134 TAKTTRQSIEQLAA* dbPAF
34 FLEDCACTPERMAEA dbPAF |