O70201

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession BIRC5_MOUSE; O70201;
Entrez ID 11799
GenBank Protein ID NM_001012273.1; NM_009689.2;
GenBank Nucleotide ID NP_001012273.1; NP_033819.1;
Protein Name Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) (TIAP)
Gene Name Birc5; Api4; Iap4
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionMultitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.
Sequence
(Fasta)
MGAPALPQIW QLYLKNYRIA TFKNWPFLED CACTPERMAE AGFIHCPTEN EPDLAQCFFC 60
FKELEGWEPD DNPIEEHRKH SPGCAFLTVK KQMEELTVSE FLKLDRQRAK NKIAKETNNK 120
QKEFEETAKT TRQSIEQLAA 141

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationBreast cancer/tumor/carcinomaNT3418816410
[Reference]: Efficient inhibition of murine breast cancer growth and metastasis by gene transferred mouse survivin Thr34-->Ala mutant.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 18)
(view all)
MESH:D000230 ; Adenocarcinoma
MESH:D001943 ; Breast Neoplasms
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D002292 ; Carcinoma, Renal Cell
MESH:D018288 ; Carcinoma, Small Cell
MESH:D002294 ; Carcinoma, Squamous Cell

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 2)
134       TAKTTRQSIEQLAA*     dbPAF
34        FLEDCACTPERMAEA     dbPAF