| Tag | Content |
|---|---|
| UniProt Accession | JAK2_HUMAN; O60674; |
| Entrez ID | 3717 |
| GenBank Protein ID | NM_001322194.1; NM_001322195.1; NM_001322196.1; NM_001322204.1; NM_004972.3; |
| GenBank Nucleotide ID | NP_001309123.1; NP_001309124.1; NP_001309125.1; NP_001309133.1; NP_004963.1; |
| Protein Name | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) |
| Gene Name | JAK2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-bindi(view all) |
| Sequence (Fasta) | MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHSLGKS EADYLTFPSG 60 EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NVLYRIRFYF 120 PRWYCSGSNR AYRHGISRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 180 MAVLDMMRIA KENDQTPLAI YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF 240 SQCKATARNL KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR 300 GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK NLEIELSSLR 360 EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIQSNC HGPISMDFAI SKLKKAGNQT 420 GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENE EYNLSGTKKN FSSLKDLLNC 480 YQMETVRSDN IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI 540 RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 600 MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK LEVAKQLAWA 660 MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 720 PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL 780 ANLINNCMDY EPDFRPSFRA IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 840 PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900 ILKSLQHDNI VKYKGVCYSA GRRNLKLIME YLPYGSLRDY LQKHKERIDH IKLLQYTSQI 960 CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 1020 YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE 1080 LLKNNGRLPR PDGCPDEIYM IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG 1133 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | ALL, AML, MPN, CML |
| CTD (Curated) (count: 25) (view all) | MESH:D000022
; Abortion, Spontaneous MESH:D006502 ; Budd-Chiari Syndrome MESH:D002114 ; Calcinosis MESH:D003093 ; Colitis, Ulcerative MESH:D006349 ; Heart Valve Diseases MESH:D007249 ; Inflammation |
| DisGeNet (Curated) (count: 96) (view all) | C0000737; Abdominal Pain
C0000786; Spontaneous abortion C0001815; Primary Myelofibrosis C0002962; Angina Pectoris C0003862; Arthralgia C0003962; Ascites |
| GWASdb (count: 8) (view all) | rs2274471; Crohn's disease; Crohn's disease
rs7849191; Crohn's disease; Crohn's disease rs2890618; Depression (quantitative trait); mental depression rs1327493; Depression (quantitative trait); mental depression rs6476934; Depression (quantitative trait); mental depression rs1536800; Alzheimer's disease (late onset); Alzheimer's disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 25) (view all) | 1007 VLPQDKEYYKVKEPG dbPAF
1008 LPQDKEYYKVKEPGE dbPAF 119 VLYRIRFYFPRWYCS dbPAF 201 DQTPLAIYNSISYKT dbPAF 206 AIYNSISYKTFLPKC dbPAF 221 IRAKIQDYHILTRKR dbPAF |
| Ubiquitination (count: 3) | 212 SYKTFLPKCIRAKIQ PLMD
244 IQQFSQCKATARNLK PLMD 762 SALDSQRKLQFYEDR PLMD |
| Sumoylation (count: 6) | 1011 DKEYYKVKEPGESPI PLMD
167 DFVHGWIKVPVTHET PLMD 630 ILVQEFVKFGSLDTY PLMD 912 LQHDNIVKYKGVCYS PLMD 914 HDNIVKYKGVCYSAG PLMD 991 VENENRVKIGDFGLT PLMD |
| Glycation (count: 2) | 1055 FTYIEKSKSPPAEFM PLMD
1069 MRMIGNDKQGQMIVF PLMD |