O60343

※ Protein Information

Tag	Content
UniProt Accession	TBCD4_HUMAN; O60343;
Entrez ID	9882
GenBank Protein ID	NM_001286658.2; NM_001286659.2; NM_014832.4;
GenBank Nucleotide ID	NP_001273587.1; NP_001273588.1; NP_055647.2;
Protein Name	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)
Gene Name	TBC1D4; AS160; KIAA0603
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. Functional Description May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Sequence (Fasta)	MEPPSCIQDE PFPHPLEPEP GVSAQPGPGK PSDKRFRLWY VGGSCLDHRT TLPMLPWLMA 60 EIRRRSQKPE AGGCGAPAAR EVILVLSAPF LRCVPAPGAG ASGGTSPSAT QPNPAVFIFE 120 HKAQHISRFI HNSHDLTYFA YLIKAQPDDP ESQMACHVFR ATDPSQVPDV ISSIRQLSKA 180 AMKEDAKPSK DNEDAFYNSQ KFEVLYCGKV TVTHKKAPSS LIDDCMEKFS LHEQQRLKIQ 240 GEQRGPDPGE DLADLEVVVP GSPGDCLPEE ADGTDTHLGL PAGASQPALT SSRVCFPERI 300 LEDSGFDEQQ EFRSRCSSVT GVQRRVHEGS QKSQPRRRHA SAPSHVQPSD SEKNRTMLFQ 360 VGRFEINLIS PDTKSVVLEK NFKDISSCSQ GIKHVDHFGF ICRESPEPGL SQYICYVFQC 420 ASESLVDEVM LTLKQAFSTA AALQSAKTQI KLCEACPMHS LHKLCERIEG LYPPRAKLVI 480 QRHLSSLTDN EQADIFERVQ KMKPVSDQEE NELVILHLRQ LCEAKQKTHV HIGEGPSTIS 540 NSTIPENATS SGRFKLDILK NKAKRSLTSS LENIFSRGAN RMRGRLGSVD SFERSNSLAS 600 EKDYSPGDSP PGTPPASPPS SAWQTFPEED SDSPQFRRRA HTFSHPPSST KRKLNLQDGR 660 AQGVRSPLLR QSSSEQCSNL SSVRRMYKES NSSSSLPSLH TSFSAPSFTA PSFLKSFYQN 720 SGRLSPQYEN EIRQDTASES SDGEGRKRTS STCSNESLSV GGTSVTPRRI SWRQRIFLRV 780 ASPMNKSPSA MQQQDGLDRN ELLPLSPLSP TMEEEPLVVF LSGEDDPEKI EERKKSKELR 840 SLWRKAIHQQ ILLLRMEKEN QKLEASRDEL QSRKVKLDYE EVGACQKEVL ITWDKKLLNC 900 RAKIRCDMED IHTLLKEGVP KSRRGEIWQF LALQYRLRHR LPNKQQPPDI SYKELLKQLT 960 AQQHAILVDL GRTFPTHPYF SVQLGPGQLS LFNLLKAYSL LDKEVGYCQG ISFVAGVLLL 1020 HMSEEQAFEM LKFLMYDLGF RKQYRPDMMS LQIQMYQLSR LLHDYHRDLY NHLEENEISP 1080 SLYAAPWFLT LFASQFSLGF VARVFDIIFL QGTEVIFKVA LSLLSSQETL IMECESFENI 1140 VEFLKNTLPD MNTSEMEKII TQVFEMDISK QLHAYEVEYH VLQDELQESS YSCEDSETLE 1200 KLERANSQLK RQNMDLLEKL QVAHTKIQAL ESNLENLLTR ETKMKSLIRT LEQEKMAYQK 1260 TVEQLRKLLP ADALVNCDLL LRDLNCNPNN KAKIGNKP 1299 Fasta Sequence >O60343\|TBC1D4; AS160; KIAA0603\|Homo sapiens (Human) MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Serine Phosphorylation	Diabetes mellitus	D	S318	20938636
1	[Reference]: Before training, reductions in insulin-stimulated R (d), together with impaired insulin-stimulated glycogen synthase fractional velocity, Akt Thr???? phosphorylation and phosphorylation of TBC1D4 at Ser???
2	Serine Phosphorylation	Diabetes mellitus	D	S588	20938636
2	[Reference]: Before training, reductions in insulin-stimulated R (d), together with impaired insulin-stimulated glycogen synthase fractional velocity, Akt Thr???? phosphorylation and phosphorylation of TBC1D4 at Ser???
3	Serine Phosphorylation	Diabetes mellitus	D	S751	20938636
3	[Reference]: Before training, reductions in insulin-stimulated R (d), together with impaired insulin-stimulated glycogen synthase fractional velocity, Akt Thr???? phosphorylation and phosphorylation of TBC1D4 at Ser???

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 1)	OMIM:616087 ; DIABETES MELLITUS, NONINSULIN-DEPENDENT, 5
GWASdb (count: 29) (view all)	rs9318335; Serum metabolites; Null rs2274758; Serum metabolites; Null rs724543; Serum metabolites; Null rs2297204; Serum metabolites; Null rs2297205; Serum metabolites; Null rs8002876; Serum metabolites; Null rs548191; Serum metabolites; Null rs568040; Serum metabolites; Null rs576810; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs2774170; Smoking initiation; nicotine dependence rs982925; Urinary metabolites; kidney disease rs1028794; Multiple complex diseases; Null rs1028794; Coronary Artery Disease; coronary artery disease rs9530434; Multiple sclerosis (brain glutamate levels); multiple sclerosis rs9565163; Blood Pressure; hypertension rs9543928; Blood Pressure; hypertension rs2328943; Urinary metabolites; kidney disease rs4883998; Response to cytidine analogues (gemcitabine); cancer rs9573545; Diabetic retinopathy; diabetic retinopathy rs9573546; Suicide attempts in bipolar disorder; bipolar disorder rs9573546; Diabetic retinopathy; diabetic retinopathy rs17071227; Multiple complex diseases; Null rs7988372; Suicide attempts in bipolar disorder; bipolar disorder rs9573553; Diabetic retinopathy; diabetic retinopathy rs9565164; Diabetic retinopathy; diabetic retinopathy rs9573555; Diabetic retinopathy; diabetic retinopathy rs4883999; Diabetic retinopathy; diabetic retinopathy rs7335576; Diabetic retinopathy; diabetic retinopathy rs9565165; Diabetic retinopathy; diabetic retinopathy

Database

Annotation

CTD (Curated)
(count: 1)

OMIM:616087 ; DIABETES MELLITUS, NONINSULIN-DEPENDENT, 5

GWASdb
(count: 29)
(view all)

rs9318335; Serum metabolites; Null
rs2274758; Serum metabolites; Null
rs724543; Serum metabolites; Null
rs2297204; Serum metabolites; Null
rs2297205; Serum metabolites; Null
rs8002876; Serum metabolites; Null

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 77) (view all)	102 PAPGAGASGGTSPSA dbPAF 105 GAGASGGTSPSATQP dbPAF 1056 MSLQIQMYQLSRLLH dbPAF 106 AGASGGTSPSATQPN dbPAF 108 ASGGTSPSATQPNPA dbPAF 1191 DELQESSYSCEDSET dbPAF 1207 EKLERANSQLKRQNM dbPAF 1246 TRETKMKSLIRTLEQ dbPAF 262 LEVVVPGSPGDCLPE dbPAF 274 LPEEADGTDTHLGLP dbPAF 285 LGLPAGASQPALTSS dbPAF 304 PERILEDSGFDEQQE dbPAF 314 DEQQEFRSRCSSVTG dbPAF 317 QEFRSRCSSVTGVQR dbPAF 318 EFRSRCSSVTGVQRR dbPAF 320 RSRCSSVTGVQRRVH dbPAF 341 QPRRRHASAPSHVQP dbPAF 344 RRHASAPSHVQPSDS dbPAF 349 APSHVQPSDSEKNRT dbPAF 351 SHVQPSDSEKNRTML dbPAF 356 SDSEKNRTMLFQVGR dbPAF 370 RFEINLISPDTKSVV dbPAF 485 LVIQRHLSSLTDNEQ dbPAF 486 VIQRHLSSLTDNEQA dbPAF 549 STIPENATSSGRFKL dbPAF 550 TIPENATSSGRFKLD dbPAF 551 IPENATSSGRFKLDI dbPAF 566 LKNKAKRSLTSSLEN dbPAF 568 NKAKRSLTSSLENIF dbPAF 569 KAKRSLTSSLENIFS dbPAF 570 AKRSLTSSLENIFSR dbPAF 576 SSLENIFSRGANRMR dbPAF 588 RMRGRLGSVDSFERS dbPAF 591 GRLGSVDSFERSNSL dbPAF 595 SVDSFERSNSLASEK dbPAF 597 DSFERSNSLASEKDY dbPAF 600 ERSNSLASEKDYSPG dbPAF 604 SLASEKDYSPGDSPP dbPAF 605 LASEKDYSPGDSPPG dbPAF 609 KDYSPGDSPPGTPPA dbPAF 613 PGDSPPGTPPASPPS dbPAF 617 PPGTPPASPPSSAWQ dbPAF 620 TPPASPPSSAWQTFP dbPAF 621 PPASPPSSAWQTFPE dbPAF 625 PPSSAWQTFPEEDSD dbPAF 631 QTFPEEDSDSPQFRR dbPAF 633 FPEEDSDSPQFRRRA dbPAF 642 QFRRRAHTFSHPPSS dbPAF 644 RRRAHTFSHPPSSTK dbPAF 648 HTFSHPPSSTKRKLN dbPAF 649 TFSHPPSSTKRKLNL dbPAF 650 FSHPPSSTKRKLNLQ dbPAF 66 MAEIRRRSQKPEAGG dbPAF 666 GRAQGVRSPLLRQSS dbPAF 672 RSPLLRQSSSEQCSN dbPAF 673 SPLLRQSSSEQCSNL dbPAF 678 QSSSEQCSNLSSVRR dbPAF 701 SSLPSLHTSFSAPSF dbPAF 704 PSLHTSFSAPSFTAP dbPAF 707 HTSFSAPSFTAPSFL dbPAF 725 YQNSGRLSPQYENEI dbPAF 749 DGEGRKRTSSTCSNE dbPAF 750 GEGRKRTSSTCSNES dbPAF 751 EGRKRTSSTCSNESL dbPAF 752 GRKRTSSTCSNESLS dbPAF 754 KRTSSTCSNESLSVG dbPAF 757 SSTCSNESLSVGGTS dbPAF 759 TCSNESLSVGGTSVT dbPAF 763 ESLSVGGTSVTPRRI dbPAF 764 SLSVGGTSVTPRRIS dbPAF 766 SVGGTSVTPRRISWR dbPAF 782 RIFLRVASPMNKSPS dbPAF 787 VASPMNKSPSAMQQQ dbPAF 789 SPMNKSPSAMQQQDG dbPAF 806 RNELLPLSPLSPTME dbPAF 809 LLPLSPLSPTMEEEP dbPAF 811 PLSPLSPTMEEEPLV dbPAF
Acetylation (count: 2)	383 VVLEKNFKDISSCSQ PLMD 477 GLYPPRAKLVIQRHL PLMD
Ubiquitination (count: 6)	1245 LTRETKMKSLIRTLE PLMD 1255 IRTLEQEKMAYQKTV PLMD 1267 KTVEQLRKLLPADAL PLMD 68 EIRRRSQKPEAGGCG PLMD 786 RVASPMNKSPSAMQQ PLMD 862 RMEKENQKLEASRDE PLMD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites