Tag | Content |
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UniProt Accession | PI51C_HUMAN; O60331; |
Entrez ID | 23396 |
GenBank Protein ID | NM_001195733.1; NM_001300849.1; NM_012398.2; |
GenBank Nucleotide ID | NP_001182662.1; NP_001287778.1; NP_036530.1; |
Protein Name | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1-gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I gamma) (PIP5KIgamma) |
Gene Name | PIP5K1C; KIAA0589 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion(view all) |
Sequence (Fasta) | MELEVPDEAE SAEAGAVPSE AAWAAESGAA AGLAQKKAAP TEVLSMTAQP GPGHGKKLGH 60 RGVDASGETT YKKTTSSTLK GAIQLGIGYT VGHLSSKPER DVLMQDFYVV ESIFFPSEGS 120 NLTPAHHFQD FRFKTYAPVA FRYFRELFGI RPDDYLYSLC NEPLIELSNP GASGSLFYVT 180 SDDEFIIKTV MHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCVQSGG KNIRVVVMNN 240 ILPRVVKMHL KFDLKGSTYK RRASKKEKEK SFPTYKDLDF MQDMPEGLLL DADTFSALVK 300 TLQRDCLVLE SFKIMDYSLL LGVHNIDQHE RERQAQGAQS TSDEKRPVGQ KALYSTAMES 360 IQGGAARGEA IESDDTMGGI PAVNGRGERL LLHIGIIDIL QSYRFIKKLE HTWKALVHDG 420 DTVSVHRPSF YAERFFKFMS NTVFRKNSSL KSSPSKKGRG GALLAVKPLG PTAAFSASQI 480 PSEREEAQYD LRGARSYPTL EDEGRPDLLP CTPPSFEEAT TASIATTLSS TSLSIPERSP 540 SETSEQPRYR RRTQSSGQDG RPQEEPPAEE DLQQITVQVE PACSVEIVVP KEEDAGVEAS 600 PAGASAAVEV ETASQASDEE GAPASQASDE EDAPATDIYF PTDERSWVYS PLHYSAQAPP 660 ASDGESDT 669 |
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Database | Annotation |
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CTD (Curated) (count: 1) | MESH:C566961 ; Lethal Congenital Contractural Syndrome 3 |
DisGeNet (Curated) (count: 10) (view all) | C0003886; Arthrogryposis
C0035229; Respiratory Insufficiency C0234958; muscle degeneration C0270948; Neurogenic Muscular Atrophy C0410916; Neonatal Death C0541794; Skeletal muscle atrophy |
HGMD (count: 1) | CM073263; Contracture syndrome type 3; Missense/nonsense
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PTM | Modification Sites |
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Phosphorylation (count: 18) (view all) | 136 QDFRFKTYAPVAFRY dbPAF
228 YGLYCVQSGGKNIRV dbPAF 402 GIIDILQSYRFIKKL dbPAF 403 IIDILQSYRFIKKLE dbPAF 45 AAPTEVLSMTAQPGP dbPAF 47 PTEVLSMTAQPGPGH dbPAF |
Ubiquitination (count: 5) | 345 AQSTSDEKRPVGQKA PLMD
351 EKRPVGQKALYSTAM PLMD 414 KKLEHTWKALVHDGD PLMD 467 GGALLAVKPLGPTAA PLMD 97 TVGHLSSKPERDVLM PLMD |
Glycation (count: 1) | 37 AAGLAQKKAAPTEVL PLMD |
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