Tag | Content |
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UniProt Accession | PRKN_HUMAN; O60260; |
Entrez ID | 5071 |
GenBank Protein ID | NM_004562.2; NM_013987.2; NM_013988.2; |
GenBank Nucleotide ID | NP_004553.2; NP_054642.2; NP_054643.2; |
Protein Name | E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.27) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) |
Gene Name | PRKN; PARK2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiqui(view all) |
Sequence (Fasta) | MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD 60 LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA 120 VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP 180 SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT 240 CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE 300 LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC 360 GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR 420 CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV 466 |
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Database | Annotation |
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CTD (Curated) (count: 11) (view all) | MESH:D001321
; Autistic Disorder MESH:D003110 ; Colonic Neoplasms MESH:D005909 ; Glioblastoma MESH:D007918 ; Leprosy MESH:D008175 ; Lung Neoplasms MESH:D020149 ; Manganese Poisoning |
PTM | Modification Sites |
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Phosphorylation (count: 17) (view all) | 101 GCEREPQSLTRVDLS dbPAF
108 SLTRVDLSSSVLPGD dbPAF 116 SSVLPGDSVGLAVIL dbPAF 131 HTDSRKDSPPAGSPA dbPAF 136 KDSPPAGSPAGRSIY dbPAF 143 SPAGRSIYNSFYVYC dbPAF |
Ubiquitination (count: 6) | 129 ILHTDSRKDSPPAGS PLMD
27 DTSIFQLKEVVAKRQ PLMD 408 ARWEAASKETIKKTT PLMD 412 AASKETIKKTTKPCP PLMD 48 LRVIFAGKELRNDWT PLMD 76 IVQRPWRKGQEMNAT PLMD |
Network | Interaction | ||
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A | B | Source | |