O60260

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PRKN_HUMAN; O60260;
Entrez ID 5071
GenBank Protein ID NM_004562.2; NM_013987.2; NM_013988.2;
GenBank Nucleotide ID NP_004553.2; NP_054642.2; NP_054643.2;
Protein Name E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.27) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene Name PRKN; PARK2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionFunctions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiqui(view all)
Sequence
(Fasta)
MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD 60
LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA 120
VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP 180
SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT 240
CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE 300
LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC 360
GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR 420
CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV 466

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationParkinson's diseaseNS13117327227
[Reference]: Additionally, the S131A Parkin mutant more significantly accumulated into inclusions in human dopaminergic cells when compared with the wild-type Parkin.
2Tyrosine PhosphorylationParkinson's diseaseUY14320823226
[Reference]: Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 11)
(view all)
MESH:D001321 ; Autistic Disorder
MESH:D003110 ; Colonic Neoplasms
MESH:D005909 ; Glioblastoma
MESH:D007918 ; Leprosy
MESH:D008175 ; Lung Neoplasms
MESH:D020149 ; Manganese Poisoning

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 17)
(view all)
101       GCEREPQSLTRVDLS     dbPAF
108       SLTRVDLSSSVLPGD     dbPAF
116       SSVLPGDSVGLAVIL     dbPAF
131       HTDSRKDSPPAGSPA     dbPAF
136       KDSPPAGSPAGRSIY     dbPAF
143       SPAGRSIYNSFYVYC     dbPAF
Ubiquitination
(count: 6)
129       ILHTDSRKDSPPAGS     PLMD
27        DTSIFQLKEVVAKRQ     PLMD
408       ARWEAASKETIKKTT     PLMD
412       AASKETIKKTTKPCP     PLMD
48        LRVIFAGKELRNDWT     PLMD
76        IVQRPWRKGQEMNAT     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource