O55042

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SYUA_MOUSE; O55042;
Entrez ID 20617
GenBank Protein ID NM_001042451.2; NM_009221.2;
GenBank Nucleotide ID NP_001035916.1; NP_033247.1;
Protein Name Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene Name Snca; Syn
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionMay be involved in the regulation of dopamine release and transport.
Sequence
(Fasta)		MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK 60
EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP 120
GSEAYEMPSE EGYQDYEPEA 141

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationParkinson's diseaseNeuro2a cellsNS12917360705
[Reference]: Here, we show that compared with coexpression of wild type (WT)alpha-syn and Ub, coexpression of phospho-mimic mutant alpha-syn (S129D) and Ub in neuro2a cells results in an increase of Ub-conjugates and the formation of ubiquitinated inclusions.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 16)
(view all)		MESH:D000437 ; Alcoholism
MESH:D019969 ; Amphetamine-Related Disorders
MESH:D019970 ; Cocaine-Related Disorders
MESH:D004195 ; Disease Models, Animal
MESH:D005776 ; Gaucher Disease
MESH:D006527 ; Hepatolenticular Degeneration

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 3)		 129       SEAYEMPSEEGYQDY     dbPAF
39        KTKEGVLYVGSKTKE     dbPAF
42        EGVLYVGSKTKEGVV     dbPAF
Ubiquitination
(count: 2)		 6         **MDVFMKGLSKAKE     PLMD
96        AAATGFVKKDQMGKG     PLMD
Methylation
(count: 2)		 12        MKGLSKAKEGVVAAA     PLMD
45        LYVGSKTKEGVVHGV     PLMD