| Tag | Content |
|---|---|
| UniProt Accession | FOXO3_HUMAN; O43524; |
| Entrez ID | 2309 |
| GenBank Protein ID | NM_001455.3; NM_201559.2; XM_005266868.3; XM_011535628.2; XM_011535629.2; XM_017010586.1; |
| GenBank Nucleotide ID | NP_001446.1; NP_963853.1; XP_005266925.1; XP_011533930.1; XP_011533931.1; XP_016866075.1; |
| Protein Name | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) |
| Gene Name | FOXO3; FKHRL1; FOXO3A |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. |
| Sequence (Fasta) | MAEAPASPAP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE TAADSMIPEE 60 EDDEDDEDGG GRAGSAMAIG GGGGSGTLGS GLLLEDSARV LAPGGQDPGS GPATAAGGLS 120 GGTQALLQPQ QPLPPPQPGA AGGSGQPRKC SSRRNAWGNL SYADLITRAI ESSPDKRLTL 180 SQIYEWMVRC VPYFKDKGDS NSSAGWKNSI RHNLSLHSRF MRVQNEGTGK SSWWIINPDG 240 GKSGKAPRRR AVSMDNSNKY TKSRGRAAKK KAALQTAPES ADDSPSQLSK WPGSPTSRSS 300 DELDAWTDFR SRTNSNASTV SGRLSPIMAS TELDEVQDDD APLSPMLYSS SASLSPSVSK 360 PCTVELPRLT DMAGTMNLND GLTENLMDDL LDNITLPPSQ PSPTGGLMQR SSSFPYTTKG 420 SGLGSPTSSF NSTVFGPSSL NSLRQSPMQT IQENKPATFS SMSHYGNQTL QDLLTSDSLS 480 HSDVMMTQSD PLMSQASTAV SAQNSRRNVM LRNDPMMSFA AQPNQGSLVN QNLLHHQHQT 540 QGALGGSRAL SNSVSNMGLS ESSSLGSAKH QQQSPVSQSM QTLSDSLSGS SLYSTSANLP 600 VMGHEKFPSD LDLDMFNGSL ECDMESIIRS ELMDADGLDF NFDSLISTQN VVGLNVGNFT 660 GAKQASSQSW VPG 674 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Database | Annotation |
|---|---|
| Cancer Gene Census | AL |
| CTD (Curated) (count: 6) | MESH:C538231
; Adenocarcinoma of lung MESH:D003528 ; Carcinoma, Adenoid Cystic MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D002289 ; Carcinoma, Non-Small-Cell Lung MESH:D009765 ; Obesity MESH:D029424 ; Pulmonary Disease, Chronic Obstructive |
| DisGeNet (Curated) (count: 7) (view all) | C0005586; Bipolar Disorder
C0007131; Non-Small Cell Lung Carcinoma C0010606; Adenoid Cystic Carcinoma C0011853; Diabetes Mellitus, Experimental C0024117; Chronic Obstructive Airway Disease C0028754; Obesity |
| GWASdb (count: 17) (view all) | rs2253310; Multiple complex diseases; Null
rs9372190; Multiple complex diseases; Null rs2490272; Multiple complex diseases; Null rs2802288; Intelligence; attention deficit hyperactivity disorder|cognitive disorder rs2802290; Body mass index; obesity rs12206094; Intelligence; attention deficit hyperactivity disorder|cognitive disorder |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 46) (view all) | 12 PASPAPLSPLEVELD dbPAF
161 RNAWGNLSYADLITR dbPAF 162 NAWGNLSYADLITRA dbPAF 179 SSPDKRLTLSQIYEW dbPAF 184 RLTLSQIYEWMVRCV dbPAF 209 SSAGWKNSIRHNLSL dbPAF |
| Acetylation (count: 5) | 242 IINPDGGKSGKAPRR PLMD
259 VSMDNSNKYTKSRGR PLMD 271 RGRAAKKKAALQTAP PLMD 290 DSPSQLSKWPGSPTS PLMD 569 SSSLGSAKHQQQSPV PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||