Tag | Content |
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UniProt Accession | SUV91_HUMAN; O43463; |
Entrez ID | 6839 |
GenBank Protein ID | NM_001282166.1; NM_003173.3; |
GenBank Nucleotide ID | NP_001269095.1; NP_003164.1; |
Protein Name | Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) |
Gene Name | SUV39H1; KMT1A; SUV39H |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required(view all) |
Sequence (Fasta) | MAENLKGCSV CCKSSWNQLQ DLCRLAKLSC PALGISKRNL YDFEVEYLCD YKKIREQEYY 60 LVKWRGYPDS ESTWEPRQNL KCVRILKQFH KDLERELLRR HHRSKTPRHL DPSLANYLVQ 120 KAKQRRALRR WEQELNAKRS HLGRITVENE VDLDGPPRAF VYINEYRVGE GITLNQVAVG 180 CECQDCLWAP TGGCCPGASL HKFAYNDQGQ VRLRAGLPIY ECNSRCRCGY DCPNRVVQKG 240 IRYDLCIFRT DDGRGWGVRT LEKIRKNSFV MEYVGEIITS EEAERRGQIY DRQGATYLFD 300 LDYVEDVYTV DAAYYGNISH FVNHSCDPNL QVYNVFIDNL DERLPRIAFF ATRTIRAGEE 360 LTFDYNMQVD PVDMESTRMD SNFGLAGLPG SPKKRVRIEC KCGTESCRKY LF 413 |
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PTM | Modification Sites |
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Phosphorylation (count: 4) | 146 RSHLGRITVENEVDL dbPAF
224 LPIYECNSRCRCGYD dbPAF 391 GLAGLPGSPKKRVRI dbPAF 70 KWRGYPDSESTWEPR dbPAF |
Ubiquitination (count: 7) (view all) | 121 LANYLVQKAKQRRAL PLMD
123 NYLVQKAKQRRALRR PLMD 138 WEQELNAKRSHLGRI PLMD 202 CPGASLHKFAYNDQG PLMD 37 CPALGISKRNLYDFE PLMD 6 **MAENLKGCSVCCK PLMD |
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