Tag | Content |
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UniProt Accession | RIPK2_HUMAN; O43353; |
Entrez ID | 8767 |
GenBank Protein ID | NM_003821.5; XM_005251092.3; |
GenBank Nucleotide ID | NP_003812.1; XP_005251149.1; |
Protein Name | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP- |
Gene Name | RIPK2; CARDIAK; RICK; RIP2; UNQ277/PRO314/PRO34092 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiq(view all) |
Sequence (Fasta) | MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER 60 KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL 120 RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS 180 SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY 240 SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI 300 TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET 360 SRSLPAPQDN DFLSRKAQDC YFMKLHHCPG NHSWDSTISG SQRAAFCDHK TTPCSSAIIN 420 PLSTAGNSER LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK 480 PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM 540 541 |
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Database | Annotation |
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CTD (Curated) (count: 1) | MESH:D003093 ; Colitis, Ulcerative |
GWASdb (count: 3) | rs13262484; Personality dimensions; personality disorder
rs42490; Leprosy; leprosy rs10097279; Major depressive disorder; major depressive disorder |
PTM | Modification Sites |
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Phosphorylation (count: 26) (view all) | 168 KIADFGLSKWRMMSL dbPAF
174 LSKWRMMSLSQSRSS dbPAF 176 KWRMMSLSQSRSSKS dbPAF 178 RMMSLSQSRSSKSAP dbPAF 181 SLSQSRSSKSAPEGG dbPAF 23 HKLADLRYLSRGASG dbPAF |
Ubiquitination (count: 5) | 182 LSQSRSSKSAPEGGT PLMD
203 ENYEPGQKSRASIKH PLMD 376 DNDFLSRKAQDCYFM PLMD 410 RAAFCDHKTTPCSSA PLMD 471 LSRDLIMKEDYELVS PLMD |
Network | Interaction | ||
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A | B | Source | |