O43312

※ Protein Information

Tag	Content
UniProt Accession	MTSS1_HUMAN; O43312;
Entrez ID	9788
GenBank Protein ID	NM_001282971.1; NM_001282974.1; NM_014751.5;
GenBank Nucleotide ID	NP_001269900.1; NP_001269903.1; NP_055566.3;
Protein Name	Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein)
Gene Name	MTSS1; KIAA0429; MIM
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. Functional Description May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
Sequence (Fasta)	MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA AAAFLDAFQK 60 VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL IDCLINPLQE QMEEWKKVAN 120 QLDKDHAKEY KKARQEIKKK SSDTLKLQKK AKKGRGDIQP QLDSALQDVN DKYLLLEETE 180 KQAVRKALIE ERGRFCTFIS MLRPVIEEEI SMLGEITHLQ TISEDLKSLT MDPHKLPSSS 240 EQVILDLKGS DYSWSYQTPP SSPSTTMSRK SSVCSSLNSV NSSDSRSSGS HSHSPSSHYR 300 YRSSNLAQQA PVRLSSVSSH DSGFISQDAF QSKSPSPMPP EAPNQLSNGF SHYSLSSESH 360 VGPTGAGLFP HCLPASRLLP RVTSVHLPDY AHYYTIGPGM FPSSQIPSWK DWAKPGPYDQ 420 PLVNTLQRRK EKREPDPNGG GPTTASGPPA AAEEAQRPRS MTVSAATRPG EEMEACEELA 480 LALSRGLQLD TQRSSRDSLQ CSSGYSTQTT TPCCSEDTIP SQVSDYDYFS VSGDQEADQQ 540 EFDKSSTIPR NSDISQSYRR MFQAKRPAST AGLPTTLGPA MVTPGVATIR RTPSTKPSVR 600 RGTIGAGPIP IKTPVIPVKT PTVPDLPGVL PAPPDGPEER GEHSPESPSV GEGPQGVTSM 660 PSSMWSGQAS VNPPLPGPKP SIPEEHRQAI PESEAEDQER EPPSATVSPG QIPESDPADL 720 SPRDTPQGED MLNAIRRGVK LKKTTTNDRS APRFS 756 Fasta Sequence >O43312\|MTSS1; KIAA0429; MIM\|Homo sapiens (Human) MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PMID
1	Ubiquitination	Prostate cancer/carcinoma/adenocarcinoma	PC-3 cell line	P	24318128
1	[Reference]: SCFbeta-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration
2	Ubiquitination	Breast cancer/tumor/carcinoma	MDA-MB-231 cell line	P	24318128
2	[Reference]: SCFbeta-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 2)	MESH:D001171 ; Arthritis, Juvenile MESH:D013274 ; Stomach Neoplasms
GWASdb (count: 26) (view all)	rs3829033; Alzheimer's disease; Alzheimer's disease rs4870903; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs6470248; Cholesterol; arteriosclerosis\|coronary artery disease\|lipid metabolism disorder rs17298759; Cholesterol; arteriosclerosis\|coronary artery disease\|lipid metabolism disorder rs6470250; Leukocyte Counts; leukemia\|lymphoma\|cardiovascular system disease rs17299208; Cholesterol; arteriosclerosis\|coronary artery disease\|lipid metabolism disorder rs4871503; Lung function (forced expiratory volume in 1 second to forced vital capacity ratio); lung disease rs6470253; Schizophrenia; schizophrenia rs17372901; Urinary metabolites; kidney disease rs3857946; Lung function (forced expiratory volume in 1 second); lung disease rs2013845; Taste perception; sensory system disease rs919544; Multiple complex diseases; Null rs10094360; Taste perception; sensory system disease rs4871527; Lung function (forced expiratory volume in 1 second); lung disease rs4007936; Lung function (forced expiratory volume in 1 second); lung disease rs6470257; Taste perception; sensory system disease rs7813190; Osteosarcoma; osteosarcoma rs7831518; Cognitive impairment induced by topiramate; cognitive disorder rs3915792; Myasthenia gravis; myasthenia gravis rs2382991; Suicide attempts in bipolar disorder; bipolar disorder rs2382992; Suicide attempts in bipolar disorder; bipolar disorder rs2116081; Cognitive function; cognitive disorder rs7816758; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs11781525; IgG glycosylation; hematologic cancer\|hypersensitivity reaction type II disease rs9969518; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs1430848; Waist-Hip Ratio; obesity

Database

Annotation

CTD (Curated)
(count: 2)

MESH:D001171 ; Arthritis, Juvenile
MESH:D013274 ; Stomach Neoplasms

GWASdb
(count: 26)
(view all)

rs3829033; Alzheimer's disease; Alzheimer's disease
rs4870903; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension
rs6470248; Cholesterol; arteriosclerosis|coronary artery disease|lipid metabolism disorder
rs17298759; Cholesterol; arteriosclerosis|coronary artery disease|lipid metabolism disorder
rs6470250; Leukocyte Counts; leukemia|lymphoma|cardiovascular system disease
rs17299208; Cholesterol; arteriosclerosis|coronary artery disease|lipid metabolism disorder

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 36) (view all)	144 IKKKSSDTLKLQKKA dbPAF 255 KGSDYSWSYQTPPSS dbPAF 256 GSDYSWSYQTPPSSP dbPAF 258 DYSWSYQTPPSSPST dbPAF 261 WSYQTPPSSPSTTMS dbPAF 262 SYQTPPSSPSTTMSR dbPAF 264 QTPPSSPSTTMSRKS dbPAF 265 TPPSSPSTTMSRKSS dbPAF 266 PPSSPSTTMSRKSSV dbPAF 268 SSPSTTMSRKSSVCS dbPAF 271 STTMSRKSSVCSSLN dbPAF 272 TTMSRKSSVCSSLNS dbPAF 275 SRKSSVCSSLNSVNS dbPAF 276 RKSSVCSSLNSVNSS dbPAF 294 SSGSHSHSPSSHYRY dbPAF 315 QQAPVRLSSVSSHDS dbPAF 316 QAPVRLSSVSSHDSG dbPAF 318 PVRLSSVSSHDSGFI dbPAF 322 SSVSSHDSGFISQDA dbPAF 383 SRLLPRVTSVHLPDY dbPAF 390 TSVHLPDYAHYYTIG dbPAF 393 HLPDYAHYYTIGPGM dbPAF 394 LPDYAHYYTIGPGMF dbPAF 418 DWAKPGPYDQPLVNT dbPAF 425 YDQPLVNTLQRRKEK dbPAF 569 FQAKRPASTAGLPTT dbPAF 570 QAKRPASTAGLPTTL dbPAF 588 MVTPGVATIRRTPST dbPAF 592 GVATIRRTPSTKPSV dbPAF 594 ATIRRTPSTKPSVRR dbPAF 595 TIRRTPSTKPSVRRG dbPAF 598 RTPSTKPSVRRGTIG dbPAF 613 AGPIPIKTPVIPVKT dbPAF 644 PEERGEHSPESPSVG dbPAF 649 EHSPESPSVGEGPQG dbPAF 693 HRQAIPESEAEDQER dbPAF
Glycation (count: 2)	36 VWEDFINKAGKLQSQ PLMD 39 DFINKAGKLQSQLRT PLMD

PTM

Modification Sites

Phosphorylation
(count: 36)
(view all)

144       IKKKSSDTLKLQKKA     dbPAF
255       KGSDYSWSYQTPPSS     dbPAF
256       GSDYSWSYQTPPSSP     dbPAF
258       DYSWSYQTPPSSPST     dbPAF
261       WSYQTPPSSPSTTMS     dbPAF
262       SYQTPPSSPSTTMSR     dbPAF

Glycation
(count: 2)

36 VWEDFINKAGKLQSQ PLMD
39 DFINKAGKLQSQLRT PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

O43312	O94762	HPRD; IntAct
O43312	P23468	HPRD; DIP
O43312	P42858	HPRD; IntAct; MINT
O43312	Q14247	MINT

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction