O15551

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CLD3_HUMAN; O15551;
Entrez ID 1365
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1)
Gene Name CLDN3; C7orf1; CPETR2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPlays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Sequence
(Fasta)		MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW MNCVVQSTGQ 60
MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG AQCTNCVQDD TAKAKITIVA 120
GVLFLLAALL TLVPVSWSAN TIIRDFYNPV VPEAQKREMG AGLYVGWAAA ALQLLGGALL 180
CCSCPPREKK YTATKVVYSA PRSTGPGASL GTGYDRKDYV 221

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationOvarian cancer/carcinomaUT19224665413; 15905176
[Reference]: Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D011471 ; Prostatic Neoplasms
MESH:D013274 ; Stomach Neoplasms
DisGeNet (Curated)
(count: 2)		C0033578; Prostatic Neoplasms
C0038356; Stomach Neoplasms

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 11)
(view all)		 191       CPPREKKYTATKVVY     dbPAF
192       PPREKKYTATKVVYS     dbPAF
194       REKKYTATKVVYSAP     dbPAF
198       YTATKVVYSAPRSTG     dbPAF
199       TATKVVYSAPRSTGP     dbPAF
203       VVYSAPRSTGPGASL     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource