Tag | Content |
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UniProt Accession | PDPK1_HUMAN; O15530; |
Entrez ID | 5170 |
GenBank Protein ID | NM_001261816.1; NM_002613.4; NM_031268.5; |
GenBank Nucleotide ID | NP_001248745.1; NP_002604.1; NP_112558.2; |
Protein Name | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) |
Gene Name | PDPK1; PDK1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in (view all) |
Sequence (Fasta) | MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP 60 GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK 120 ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET 180 CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN 240 SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD 300 FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA 360 YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD 420 SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE 480 GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ 540 EVWRQRYQSH PDAAVQ 557 |
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Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D001943
; Breast Neoplasms MESH:D006333 ; Heart Failure MESH:D016403 ; Lymphoma, Large B-Cell, Diffuse |
HGMD (count: 1) | CD072462; Protein kinase deficiency; Small deletions
|
PTM | Modification Sites |
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Phosphorylation (count: 41) (view all) | 126 IKENKVPYVTRERDV dbPAF
148 FFVKLYFTFQDDEKL dbPAF 156 FQDDEKLYFGLSYAK dbPAF 160 EKLYFGLSYAKNGEL dbPAF 161 KLYFGLSYAKNGELL dbPAF 170 KNGELLKYIRKIGSF dbPAF |
Acetylation (count: 2) | 296 LIFQKIIKLEYDFPE PLMD
304 LEYDFPEKFFPKARD PLMD |
Ubiquitination (count: 6) | 123 RHIIKENKVPYVTRE PLMD
235 KVLSPESKQARANSF PLMD 257 SPELLTEKSACKSSD PLMD 304 LEYDFPEKFFPKARD PLMD 323 LLVLDATKRLGCEEM PLMD 441 EKRLLLEKQAGGNPW PLMD |
Malonylation (count: 1) | 495 DPVNKVLKGEIPWSQ PLMD |