Tag | Content |
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UniProt Accession | BIRC5_HUMAN; O15392; |
Entrez ID | 332 |
GenBank Protein ID | NM_001012270.1; NM_001012271.1; NM_001168.2; |
GenBank Nucleotide ID | NP_001012270.1; NP_001012271.1; NP_001159.2; |
Protein Name | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) |
Gene Name | BIRC5; API4; IAP4 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the ce(view all) |
Sequence (Fasta) | MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 60 FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 120 KKEFEETAKK VRRAIEQLAA MD 143 |
|
Database | Annotation |
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CTD (Curated) (count: 18) (view all) | MESH:D000230
; Adenocarcinoma MESH:D001943 ; Breast Neoplasms MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002292 ; Carcinoma, Renal Cell MESH:D018288 ; Carcinoma, Small Cell MESH:D002294 ; Carcinoma, Squamous Cell |
DisGeNet (Curated) (count: 17) (view all) | C0001418; Adenocarcinoma
C0007131; Non-Small Cell Lung Carcinoma C0007134; Renal Cell Carcinoma C0007137; Squamous cell carcinoma C0007873; Uterine Cervical Neoplasm C0009375; Colonic Neoplasms |
HGMD (count: 1) | CR087414; Lung cancer, lower risk, association with; Regulatory
|
GWASdb (count: 4) | rs12947167; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease
rs2071214; Alcohol dependence; alcohol dependence rs2071214; Behavioural disinhibition (generation interaction); alcohol dependence|nicotine dependence|lung cancer rs17879146; Periodontitis (Mean PAL); periodontitis |
PTM | Modification Sites |
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Phosphorylation (count: 5) | 117 KNKIAKETNNKKKEF dbPAF
20 FLKDHRISTFKNWPF dbPAF 21 LKDHRISTFKNWPFL dbPAF 34 FLEGCACTPERMAEA dbPAF 48 AGFIHCPTENEPDLA dbPAF |
Acetylation (count: 11) (view all) | 110 KLDRERAKNKIAKET PLMD
112 DRERAKNKIAKETNN PLMD 115 RAKNKIAKETNNKKK PLMD 120 IAKETNNKKKEFEET PLMD 121 AKETNNKKKEFEETA PLMD 122 KETNNKKKEFEETAK PLMD |
Ubiquitination (count: 6) | 103 LTLGEFLKLDRERAK PLMD
15 PAWQPFLKDHRISTF PLMD 23 DHRISTFKNWPFLEG PLMD 78 DDPIEEHKKHSSGCA PLMD 90 GCAFLSVKKQFEELT PLMD 91 CAFLSVKKQFEELTL PLMD |
Network | Interaction | ||
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A | B | Source | |