O15392

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession BIRC5_HUMAN; O15392;
Entrez ID 332
GenBank Protein ID NM_001012270.1; NM_001012271.1; NM_001168.2;
GenBank Nucleotide ID NP_001012270.1; NP_001012271.1; NP_001159.2;
Protein Name Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
Gene Name BIRC5; API4; IAP4
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMultitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the ce(view all)
Sequence
(Fasta)
MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 60
FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 120
KKEFEETAKK VRRAIEQLAA MD 143

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationCrohn's diseasetumor tissueU22749932
[Reference]: Survivin immunoprecipitation followed by ubiquitin immunoblotting in fresh control and IBD LPTs revealed that survivin ubiquitylation was much greater in CD than UC LPTs, and essentially absent in control LPTs

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 18)
(view all)
MESH:D000230 ; Adenocarcinoma
MESH:D001943 ; Breast Neoplasms
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D002292 ; Carcinoma, Renal Cell
MESH:D018288 ; Carcinoma, Small Cell
MESH:D002294 ; Carcinoma, Squamous Cell
DisGeNet (Curated)
(count: 17)
(view all)
C0001418; Adenocarcinoma
C0007131; Non-Small Cell Lung Carcinoma
C0007134; Renal Cell Carcinoma
C0007137; Squamous cell carcinoma
C0007873; Uterine Cervical Neoplasm
C0009375; Colonic Neoplasms
HGMD
(count: 1)
CR087414; Lung cancer, lower risk, association with; Regulatory
GWASdb
(count: 4)
rs12947167; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease
rs2071214; Alcohol dependence; alcohol dependence
rs2071214; Behavioural disinhibition (generation interaction); alcohol dependence|nicotine dependence|lung cancer
rs17879146; Periodontitis (Mean PAL); periodontitis

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 5)
117       KNKIAKETNNKKKEF     dbPAF
20        FLKDHRISTFKNWPF     dbPAF
21        LKDHRISTFKNWPFL     dbPAF
34        FLEGCACTPERMAEA     dbPAF
48        AGFIHCPTENEPDLA     dbPAF
Acetylation
(count: 11)
(view all)
110       KLDRERAKNKIAKET     PLMD
112       DRERAKNKIAKETNN     PLMD
115       RAKNKIAKETNNKKK     PLMD
120       IAKETNNKKKEFEET     PLMD
121       AKETNNKKKEFEETA     PLMD
122       KETNNKKKEFEETAK     PLMD
Ubiquitination
(count: 6)
103       LTLGEFLKLDRERAK     PLMD
15        PAWQPFLKDHRISTF     PLMD
23        DHRISTFKNWPFLEG     PLMD
78        DDPIEEHKKHSSGCA     PLMD
90        GCAFLSVKKQFEELT     PLMD
91        CAFLSVKKQFEELTL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
O14965O15392DIP
O14980O15392MINT
O15392O15392MINT;IntAct
O15392O76095IntAct
O15392P06493IntAct
O15392P36873IntAct
O15392P55211IntAct
O15392Q14457MINT
O15392Q15853IntAct
O15392Q53HL2DIP; IntAct; MINT
O15392Q96GD4DIP; IntAct; MINT;IntAct
O15392Q9NQS7IntAct; MINT
O15392Q9UQB9IntAct