Tag | Content |
---|---|
UniProt Accession | OGT1_HUMAN; O15294; |
Entrez ID | 8473 |
GenBank Protein ID | NM_181672.2; NM_181673.2; XM_017029907.1; XM_017029908.1; |
GenBank Nucleotide ID | NP_858058.1; NP_858059.1; XP_016885396.1; XP_016885397.1; |
Protein Name | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) |
Gene Name | OGT |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via gl(view all) |
Sequence (Fasta) | MASSVGNVAD STEPTKRMLS FQGLAELAHR EYQAGDFEAA ERHCMQLWRQ EPDNTGVLLL 60 LSSIHFQCRR LDRSAHFSTL AIKQNPLLAE AYSNLGNVYK ERGQLQEAIE HYRHALRLKP 120 DFIDGYINLA AALVAAGDME GAVQAYVSAL QYNPDLYCVR SDLGNLLKAL GRLEEAKACY 180 LKAIETQPNF AVAWSNLGCV FNAQGEIWLA IHHFEKAVTL DPNFLDAYIN LGNVLKEARI 240 FDRAVAAYLR ALSLSPNHAV VHGNLACVYY EQGLIDLAID TYRRAIELQP HFPDAYCNLA 300 NALKEKGSVA EAEDCYNTAL RLCPTHADSL NNLANIKREQ GNIEEAVRLY RKALEVFPEF 360 AAAHSNLASV LQQQGKLQEA LMHYKEAIRI SPTFADAYSN MGNTLKEMQD VQGALQCYTR 420 AIQINPAFAD AHSNLASIHK DSGNIPEAIA SYRTALKLKP DFPDAYCNLA HCLQIVCDWT 480 DYDERMKKLV SIVADQLEKN RLPSVHPHHS MLYPLSHGFR KAIAERHGNL CLDKINVLHK 540 PPYEHPKDLK LSDGRLRVGY VSSDFGNHPT SHLMQSIPGM HNPDKFEVFC YALSPDDGTN 600 FRVKVMAEAN HFIDLSQIPC NGKAADRIHQ DGIHILVNMN GYTKGARNEL FALRPAPIQA 660 MWLGYPGTSG ALFMDYIITD QETSPAEVAE QYSEKLAYMP HTFFIGDHAN MFPHLKKKAV 720 IDFKSNGHIY DNRIVLNGID LKAFLDSLPD VKIVKMKCPD GGDNADSSNT ALNMPVIPMN 780 TIAEAVIEMI NRGQIQITIN GFSISNGLAT TQINNKAATG EEVPRTIIVT TRSQYGLPED 840 AIVYCNFNQL YKIDPSTLQM WANILKRVPN SVLWLLRFPA VGEPNIQQYA QNMGLPQNRI 900 IFSPVAPKEE HVRRGQLADV CLDTPLCNGH TTGMDVLWAG TPMVTMPGET LASRVAASQL 960 TCLGCLELIA KNRQEYEDIA VKLGTDLEYL KKVRGKVWKQ RISSPLFNTK QYTMELERLY 1020 LQMWEHYAAG NKPDHMIKPV EVTESA 1047 |
|
Database | Annotation |
---|---|
GWASdb (count: 3) | rs5936630; Parkinson's disease; Parkinson's disease
rs5936630; Amyotrophic Lateral Sclerosis; amyotrophic lateral sclerosis rs11796215; Response to cytadine analogues (cytosine arabinoside); cancer |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 16) (view all) | 1045 KPVEVTESA****** dbPAF
11 SVGNVADSTEPTKRM dbPAF 15 VADSTEPTKRMLSFQ dbPAF 20 EPTKRMLSFQGLAEL dbPAF 3 *****MASSVGNVAD dbPAF 325 TALRLCPTHADSLNN dbPAF |
Acetylation (count: 6) | 16 ADSTEPTKRMLSFQG PLMD
168 SDLGNLLKALGRLEE PLMD 385 QEALMHYKEAIRISP PLMD 488 DYDERMKKLVSIVAD PLMD 534 HGNLCLDKINVLHKP PLMD 991 GTDLEYLKKVRGKVW PLMD |
Ubiquitination (count: 31) (view all) | 100 SNLGNVYKERGQLQE PLMD
1010 SSPLFNTKQYTMELE PLMD 16 ADSTEPTKRMLSFQG PLMD 168 SDLGNLLKALGRLEE PLMD 177 LGRLEEAKACYLKAI PLMD 236 INLGNVLKEARIFDR PLMD |
Sumoylation (count: 1) | 752 LDSLPDVKIVKMKCP PLMD |
Glycation (count: 2) | 742 VLNGIDLKAFLDSLP PLMD
752 LDSLPDVKIVKMKCP PLMD |
Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|